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Insulin-like growth factor I (IGF-I) (Somatomedin)

 IGF1_CAPHI              Reviewed;         154 AA.
P51457;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
14-AUG-2001, sequence version 2.
25-OCT-2017, entry version 99.
RecName: Full=Insulin-like growth factor I;
Short=IGF-I;
AltName: Full=Somatomedin;
Flags: Precursor;
Name=IGF1;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7765981; DOI=10.1271/bbb.59.87;
Mikawa S., Yoshikawa G., Aoki H., Yamano Y., Sakai H., Komano T.;
"Dynamic aspects in the expression of the goat insulin-like growth
factor-I (IGF-I) gene: diversity in transcription and post-
transcription.";
Biosci. Biotechnol. Biochem. 59:87-92(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Shiba; TISSUE=Liver;
PubMed=7772848; DOI=10.1271/bbb.59.759;
Mikawa S., Yoshikawa G., Yamano Y., Sakai H., Komano T., Hosoi Y.,
Utsumi K.;
"Tissue- and development-specific expression of goat insulin-like
growth factor-I (IGF-I) mRNAs.";
Biosci. Biotechnol. Biochem. 59:759-761(1995).
-!- FUNCTION: The insulin-like growth factors, isolated from plasma,
are structurally and functionally related to insulin but have a
much higher growth-promoting activity. May be a physiological
regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and
glycogen synthesis in osteoblasts. Stimulates glucose transport in
bone-derived osteoblastic (PyMS) cells and is effective at much
lower concentrations than insulin, not only regarding glycogen and
DNA synthesis but also with regard to enhancing glucose uptake.
May play a role in synapse maturation. Ca(2+)-dependent exocytosis
of IGF1 is required for sensory perception of smell in the
olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha
subunit of IGF1R, leading to the activation of the intrinsic
tyrosine kinase activity which autophosphorylates tyrosine
residues in the beta subunit thus initiatiating a cascade of down-
stream signaling events leading to activation of the PI3K-AKT/PKB
and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and
ITGA6:ITGB4. Its binding to integrins and subsequent ternary
complex formation with integrins and IGFR1 are essential for IGF1
signaling. Induces the phosphorylation and activation of IGFR1,
MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).
{ECO:0000250|UniProtKB:P05017, ECO:0000250|UniProtKB:P05019}.
-!- SUBUNIT: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms
a ternary complex with IGFR1 and ITGA6:ITGB4.
{ECO:0000250|UniProtKB:P05019}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
-!- TISSUE SPECIFICITY: Expressed in all tissues examined: brain,
lung, liver, spleen, uterus, ovary, testis, heart and skeletal
muscle. {ECO:0000269|PubMed:7772848}.
-!- SIMILARITY: Belongs to the insulin family. {ECO:0000305}.
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EMBL; D26119; BAB77524.1; ALT_SEQ; Genomic_DNA.
EMBL; D11378; BAA01976.1; -; mRNA.
PIR; JC2483; JC2483.
RefSeq; NP_001272626.1; NM_001285697.1.
UniGene; Chi.6376; -.
ProteinModelPortal; P51457; -.
SMR; P51457; -.
GeneID; 100860838; -.
KEGG; chx:100860838; -.
CTD; 3479; -.
HOVERGEN; HBG006137; -.
KO; K05459; -.
OrthoDB; EOG091G0H56; -.
GO; GO:0035867; C:alphav-beta3 integrin-IGF-1-IGF1R complex; ISS:UniProtKB.
GO; GO:0070382; C:exocytic vesicle; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005179; F:hormone activity; IEA:InterPro.
GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0090201; P:negative regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0046326; P:positive regulation of glucose import; ISS:UniProtKB.
GO; GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.
Gene3D; 1.10.100.10; -; 1.
InterPro; IPR022341; IGF-I.
InterPro; IPR016179; Insulin-like.
InterPro; IPR022350; Insulin-like_growth_factor.
InterPro; IPR036438; Insulin-like_sf.
InterPro; IPR022353; Insulin_CS.
InterPro; IPR022352; Insulin_family.
Pfam; PF00049; Insulin; 1.
PRINTS; PR02002; INSLNLIKEGF.
PRINTS; PR02005; INSLNLIKEGF1.
PRINTS; PR00276; INSULINFAMLY.
SMART; SM00078; IlGF; 1.
SUPFAM; SSF56994; SSF56994; 1.
PROSITE; PS00262; INSULIN; 1.
2: Evidence at transcript level;
Disulfide bond; Growth factor; Secreted; Signal.
SIGNAL 1 ? {ECO:0000255}.
PROPEP ? 49 {ECO:0000250}.
/FTId=PRO_0000015652.
CHAIN 50 119 Insulin-like growth factor I.
/FTId=PRO_0000015653.
PROPEP 120 154 E peptide.
/FTId=PRO_0000015654.
REGION 50 78 B.
REGION 79 90 C.
REGION 91 111 A.
REGION 112 119 D.
DISULFID 55 97 {ECO:0000250}.
DISULFID 67 110 {ECO:0000250}.
DISULFID 96 101 {ECO:0000250}.
SEQUENCE 154 AA; 17082 MW; 07238B6AF3068422 CRC64;
MGKISSLPTQ LFKCCFCDFL KQVKMPVTSS SHLFYLALCL LAFTSSATAG PETLCGAELV
DALQFVCGDR GFYFNKPTGY GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPTKSAR
SVRAQRHTDM PKAQKEVHLK NTSRGSAGNK NYRM


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