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Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) (mIGFBP-2)

 IBP2_MOUSE              Reviewed;         305 AA.
P47877; Q61722; Q91VK7;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
10-FEB-2009, sequence version 2.
05-DEC-2018, entry version 149.
RecName: Full=Insulin-like growth factor-binding protein 2;
Short=IBP-2;
Short=IGF-binding protein 2;
Short=IGFBP-2;
Short=mIGFBP-2;
Flags: Precursor;
Name=Igfbp2; Synonyms=Igfbp-2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=BALB/cJ; TISSUE=Fetal liver;
PubMed=7680327; DOI=10.1016/0378-1119(93)90406-S;
Landwehr J., Kaupmann K., Heinrich G., Schwander J.;
"Cloning and characterization of the gene encoding murine insulin-like
growth factor-binding protein-2, mIGFBP-2.";
Gene 124:281-286(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
TISSUE=Liver;
PubMed=7529732; DOI=10.1016/0303-7207(94)90051-5;
Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C.,
Drop S.L.S.;
"cDNA cloning and mRNA expression of the six mouse insulin-like growth
factor binding proteins.";
Mol. Cell. Endocrinol. 104:57-66(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N-3; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Inhibits IGF-mediated growth and developmental rates (By
similarity). IGF-binding proteins prolong the half-life of the
IGFs and have been shown to either inhibit or stimulate the growth
promoting effects of the IGFs on cell culture. They alter the
interaction of IGFs with their cell surface receptors.
{ECO:0000250}.
-!- SUBUNIT: Binds IGF2 more than IGF1.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Highly expressed in adult liver, but also in
kidney, lung, brain, spleen, testis and ovary.
{ECO:0000269|PubMed:7529732}.
-!- DEVELOPMENTAL STAGE: Expressed embryos at day 11.5. Also expressed
in fetal livers with expression increasing dramatically after
birth. Expression decreases only slightly after postnatal day 3
and remains abundant thereafter. {ECO:0000269|PubMed:7529732}.
-!- DOMAIN: The C-terminus is required for IGF-binding and growth
inhibition. {ECO:0000250}.
-!- PTM: O-glycosylated. {ECO:0000250}.
-----------------------------------------------------------------------
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EMBL; L05439; AAB60709.1; -; Genomic_DNA.
EMBL; L05436; AAB60709.1; JOINED; Genomic_DNA.
EMBL; L05437; AAB60709.1; JOINED; Genomic_DNA.
EMBL; L05438; AAB60709.1; JOINED; Genomic_DNA.
EMBL; X81580; CAA57270.1; -; mRNA.
EMBL; CH466548; EDL00293.1; -; Genomic_DNA.
EMBL; BC012724; AAH12724.1; -; mRNA.
EMBL; BC054473; AAH54473.1; -; mRNA.
CCDS; CCDS15036.1; -.
PIR; I48601; I48601.
PIR; JN0508; JN0508.
RefSeq; NP_032368.2; NM_008342.3.
UniGene; Mm.141936; -.
ProteinModelPortal; P47877; -.
SMR; P47877; -.
DIP; DIP-60632N; -.
IntAct; P47877; 3.
MINT; P47877; -.
STRING; 10090.ENSMUSP00000046610; -.
MEROPS; I31.953; -.
iPTMnet; P47877; -.
PhosphoSitePlus; P47877; -.
MaxQB; P47877; -.
PaxDb; P47877; -.
PeptideAtlas; P47877; -.
PRIDE; P47877; -.
Ensembl; ENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323.
GeneID; 16008; -.
KEGG; mmu:16008; -.
UCSC; uc007bkw.2; mouse.
CTD; 3485; -.
MGI; MGI:96437; Igfbp2.
eggNOG; ENOG410IHUR; Eukaryota.
eggNOG; ENOG4111GWQ; LUCA.
GeneTree; ENSGT00940000158542; -.
HOGENOM; HOG000253012; -.
HOVERGEN; HBG002631; -.
InParanoid; P47877; -.
OMA; DGTMNML; -.
OrthoDB; EOG091G0EIN; -.
PhylomeDB; P47877; -.
TreeFam; TF331211; -.
Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
ChiTaRS; Igfbp2; mouse.
PRO; PR:P47877; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000039323; Expressed in 301 organ(s), highest expression level in liver.
CleanEx; MM_IGFBP2; -.
ExpressionAtlas; P47877; baseline and differential.
Genevisible; P47877; MM.
GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
GO; GO:0031410; C:cytoplasmic vesicle; ISO:MGI.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005520; F:insulin-like growth factor binding; IPI:MGI.
GO; GO:0031994; F:insulin-like growth factor I binding; ISS:UniProtKB.
GO; GO:0031995; F:insulin-like growth factor II binding; ISS:UniProtKB.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0032870; P:cellular response to hormone stimulus; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0010226; P:response to lithium ion; IEA:Ensembl.
GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IEA:Ensembl.
CDD; cd00191; TY; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR012210; IGFBP-2.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR009168; IGFBP1-6.
InterPro; IPR022321; IGFBP_1-6_chordata.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
PANTHER; PTHR11551; PTHR11551; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PRINTS; PR01976; IGFBPFAMILY.
PRINTS; PR01978; IGFBPFAMILY2.
SMART; SM00121; IB; 1.
SMART; SM00211; TY; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein;
Growth factor binding; Growth regulation; Reference proteome;
Secreted; Signal.
SIGNAL 1 34 {ECO:0000250}.
CHAIN 35 305 Insulin-like growth factor-binding
protein 2.
/FTId=PRO_0000014371.
DOMAIN 36 118 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 204 286 Thyroglobulin type-1.
{ECO:0000255|PROSITE-ProRule:PRU00500}.
MOTIF 281 283 Cell attachment site.
DISULFID 207 241 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 252 263 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 265 286 {ECO:0000255|PROSITE-ProRule:PRU00500}.
CONFLICT 47 47 R -> A (in Ref. 2; CAA57270).
{ECO:0000305}.
CONFLICT 133 133 D -> H (in Ref. 1; AAB60709).
{ECO:0000305}.
SEQUENCE 305 AA; 32847 MW; 179FE6A304E93A16 CRC64;
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA CGPPPDAPCA
ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG SELPLKALVT GAGTCEKRRV
GTTPQQVADS DDDHSEGGLV ENHVDGTMNM LGGGSSAGRK PLKSGMKELA VFREKVNEQH
RQMGKGAKHL SLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN
CDKHGRYNLK QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH
AQSVQ


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