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Insulin-like growth factor-binding protein 3 (IBP-3) (IGF-binding protein 3) (IGFBP-3)

 IBP3_PIG                Reviewed;         293 AA.
P16611; Q6S6K2; Q9TTI0;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
07-FEB-2006, sequence version 3.
10-MAY-2017, entry version 126.
RecName: Full=Insulin-like growth factor-binding protein 3;
Short=IBP-3;
Short=IGF-binding protein 3;
Short=IGFBP-3;
Flags: Precursor;
Name=IGFBP3;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=12553871; DOI=10.1677/joe.0.1760227;
Pampusch M.S., Kamanga-Sollo E., White M.E., Hathaway M.R.,
Dayton W.R.;
"Effect of recombinant porcine IGF-binding protein-3 on proliferation
of embryonic porcine myogenic cell cultures in the presence and
absence of IGF-I.";
J. Endocrinol. 176:227-235(2003).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=14715717; DOI=10.1210/en.2003-1552;
Ongeri E.M., Zhu Q., Verderame M.F., Hammond J.M.;
"Insulin-like growth factor-binding protein-3 in porcine ovarian
granulosa cells: gene cloning, promoter mapping, and follicle-
stimulating hormone regulation.";
Endocrinology 145:1776-1785(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 28-293.
PubMed=1688850;
Shimasaki S., Shimonaka M., Ui M., Inouye S., Shibata F., Ling N.;
"Structural characterization of a follicle-stimulating hormone action
inhibitor in porcine ovarian follicular fluid. Its identification as
the insulin-like growth factor-binding protein.";
J. Biol. Chem. 265:2198-2202(1990).
[4]
PROTEIN SEQUENCE OF 28-42.
PubMed=1722398; DOI=10.1016/0006-291X(91)92056-P;
Coleman M.E., Pan Y.-C.E., Etherton T.D.;
"Identification and NH2-terminal amino acid sequence of three insulin-
like growth factor-binding proteins in porcine serum.";
Biochem. Biophys. Res. Commun. 181:1131-1136(1991).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-293.
Liu D., Zhang Y., Zhang X., Yang G.;
"Study on SNPs of porcine IGFBP-3 gene.";
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs
and have been shown to either inhibit or stimulate the growth
promoting effects of the IGFs on cell culture. They alter the
interaction of IGFs with their cell surface receptors. Also
exhibits IGF-independent antiproliferative and apoptotic effects
mediated by its receptor TMEM219/IGFBP-3R.
-!- SUBUNIT: Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a
ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85
kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219
(By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Phosphorylated by FAM20C in the extracellular medium.
{ECO:0000250|UniProtKB:P17936}.
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EMBL; AF085482; AAF23229.1; -; mRNA.
EMBL; AY464121; AAR87008.1; -; Genomic_DNA.
EMBL; J05228; AAA31054.1; -; mRNA.
EMBL; AY422045; AAQ97624.1; -; Genomic_DNA.
PIR; A35037; A35037.
PIR; JH0516; JH0516.
RefSeq; NP_001005156.1; NM_001005156.1.
UniGene; Ssc.42774; -.
ProteinModelPortal; P16611; -.
SMR; P16611; -.
STRING; 9823.ENSSSCP00000017719; -.
MEROPS; I31.952; -.
PaxDb; P16611; -.
PRIDE; P16611; -.
GeneID; 448812; -.
KEGG; ssc:448812; -.
CTD; 3486; -.
eggNOG; ENOG410IHZU; Eukaryota.
eggNOG; ENOG4111MF3; LUCA.
HOVERGEN; HBG002631; -.
InParanoid; P16611; -.
KO; K10138; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0005615; C:extracellular space; ISS:AgBase.
GO; GO:0001968; F:fibronectin binding; IBA:GO_Central.
GO; GO:0031994; F:insulin-like growth factor I binding; IBA:GO_Central.
GO; GO:0031995; F:insulin-like growth factor II binding; IBA:GO_Central.
GO; GO:0008160; F:protein tyrosine phosphatase activator activity; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; IBA:GO_Central.
GO; GO:0032868; P:response to insulin; ISS:AgBase.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR009030; Growth_fac_rcpt_.
InterPro; IPR012211; IGFBP-3.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR009168; IGFBP1-6.
InterPro; IPR022321; IGFBP_1-6_chordata.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000716; Thyroglobulin_1.
PANTHER; PTHR11551; PTHR11551; 1.
PANTHER; PTHR11551:SF22; PTHR11551:SF22; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PRINTS; PR01976; IGFBPFAMILY.
PRINTS; PR01979; IGFBPFAMILY3.
SMART; SM00121; IB; 1.
SMART; SM00211; TY; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Growth factor binding; Phosphoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 27 {ECO:0000269|PubMed:1722398}.
CHAIN 28 293 Insulin-like growth factor-binding
protein 3.
/FTId=PRO_0000045904.
DOMAIN 36 119 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 212 287 Thyroglobulin type-1.
{ECO:0000255|PROSITE-ProRule:PRU00500}.
MOD_RES 150 150 Phosphoserine.
{ECO:0000250|UniProtKB:P17936}.
MOD_RES 203 203 Phosphoserine.
{ECO:0000250|UniProtKB:P17936}.
CARBOHYD 118 118 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 138 138 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 201 201 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 215 242 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 253 264 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 266 287 {ECO:0000255|PROSITE-ProRule:PRU00500}.
CONFLICT 23 23 P -> S (in Ref. 1; AAF23229).
{ECO:0000305}.
CONFLICT 32 32 A -> V (in Ref. 1 and 3). {ECO:0000305}.
CONFLICT 170 170 V -> I (in Ref. 1; AAF23229).
{ECO:0000305}.
SEQUENCE 293 AA; 31690 MW; B2ECED337B91DA83 CRC64;
MQRARPALWA AALIALALLR GPPAARAGSG AAGTGPVVRC EPCDARALAQ CAPPPAAPPC
AELVREPGCG CCLTCALREG QACGVYTERC GAGLRCQPPP GEPRPLQALL DGRGICANAS
AAGRLRAYLL PAPPAPGNGS ESEEDRSVDS MENQALPSTH RVPDSKLHSV HTKMDVIKKG
HAKDSQRYKV DYESQSTDTQ NFSSESKRET EYGPCRREME DTLNHLKFLN MLSPRGIHIP
NCDKKGFYKK KQCRPSKGRK RGFCWCVDKY GQPLPGFDVK GKGDVHCYSM ESK


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