Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5)

 IBP5_MOUSE              Reviewed;         271 AA.
Q07079;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
12-SEP-2018, entry version 165.
RecName: Full=Insulin-like growth factor-binding protein 5;
Short=IBP-5;
Short=IGF-binding protein 5;
Short=IGFBP-5;
Flags: Precursor;
Name=Igfbp5; Synonyms=Igfbp-5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Myoblast;
PubMed=7693664;
James P.L., Jones S.B., Busby W.H. Jr., Clemmons D.R., Rotwein P.;
"A highly conserved insulin-like growth factor-binding protein (IGFBP-
5) is expressed during myoblast differentiation.";
J. Biol. Chem. 268:22305-22312(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Spleen;
PubMed=7518410; DOI=10.1006/geno.1994.1195;
Kou K., Jenkins N.A., Gilbert D.J., Copeland N.G., Rotwein P.;
"Organization, expression, and chromosomal location of the mouse
insulin-like growth factor binding protein 5 gene.";
Genomics 20:412-418(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=7529732; DOI=10.1016/0303-7207(94)90051-5;
Schuller A.G.P., Groffen C., van Neck J.W., Zwarthoff E.C.,
Drop S.L.S.;
"cDNA cloning and mRNA expression of the six mouse insulin-like growth
factor binding proteins.";
Mol. Cell. Endocrinol. 104:57-66(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: IGF-binding proteins prolong the half-life of the IGFs
and have been shown to either inhibit or stimulate the growth
promoting effects of the IGFs on cell culture. They alter the
interaction of IGFs with their cell surface receptors.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Most abundant in kidney, uterus and
gastrocnemius muscle.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L12447; AAC37636.1; -; mRNA.
EMBL; U02025; AAC01750.1; -; Genomic_DNA.
EMBL; U02023; AAC01750.1; JOINED; Genomic_DNA.
EMBL; U02027; AAC01750.1; JOINED; Genomic_DNA.
EMBL; U02024; AAC01750.1; JOINED; Genomic_DNA.
EMBL; X81583; CAA57273.1; -; mRNA.
EMBL; BC054812; AAH54812.1; -; mRNA.
EMBL; BC057447; AAH57447.1; -; mRNA.
CCDS; CCDS15037.1; -.
PIR; I48604; I48604.
RefSeq; NP_034648.2; NM_010518.2.
UniGene; Mm.405761; -.
ProteinModelPortal; Q07079; -.
SMR; Q07079; -.
IntAct; Q07079; 1.
STRING; 10090.ENSMUSP00000027377; -.
MEROPS; I31.952; -.
iPTMnet; Q07079; -.
PhosphoSitePlus; Q07079; -.
PaxDb; Q07079; -.
PeptideAtlas; Q07079; -.
PRIDE; Q07079; -.
Ensembl; ENSMUST00000027377; ENSMUSP00000027377; ENSMUSG00000026185.
GeneID; 16011; -.
KEGG; mmu:16011; -.
UCSC; uc007bkx.1; mouse.
CTD; 3488; -.
MGI; MGI:96440; Igfbp5.
eggNOG; ENOG410IJJ2; Eukaryota.
eggNOG; ENOG4111GGG; LUCA.
GeneTree; ENSGT00550000074457; -.
HOGENOM; HOG000253012; -.
HOVERGEN; HBG002631; -.
InParanoid; Q07079; -.
OMA; LPIDKHE; -.
OrthoDB; EOG091G0EIN; -.
PhylomeDB; Q07079; -.
TreeFam; TF331211; -.
Reactome; R-MMU-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-MMU-8957275; Post-translational protein phosphorylation.
ChiTaRS; Igfbp5; mouse.
PMAP-CutDB; Q07079; -.
PRO; PR:Q07079; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026185; Expressed in 314 organ(s), highest expression level in cochlea.
CleanEx; MM_IGFBP5; -.
ExpressionAtlas; Q07079; baseline and differential.
Genevisible; Q07079; MM.
GO; GO:0016942; C:insulin-like growth factor binding protein complex; IC:MGI.
GO; GO:0042567; C:insulin-like growth factor ternary complex; ISS:BHF-UCL.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0001968; F:fibronectin binding; IDA:MGI.
GO; GO:0005520; F:insulin-like growth factor binding; ISO:MGI.
GO; GO:0031994; F:insulin-like growth factor I binding; ISO:MGI.
GO; GO:0031995; F:insulin-like growth factor II binding; IBA:GO_Central.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0071320; P:cellular response to cAMP; ISO:MGI.
GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:MGI.
GO; GO:0007565; P:female pregnancy; IMP:BHF-UCL.
GO; GO:0042593; P:glucose homeostasis; IMP:MGI.
GO; GO:0006006; P:glucose metabolic process; IMP:MGI.
GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0048286; P:lung alveolus development; IMP:BHF-UCL.
GO; GO:0060056; P:mammary gland involution; IMP:MGI.
GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
GO; GO:0045926; P:negative regulation of growth; IMP:BHF-UCL.
GO; GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:MGI.
GO; GO:1901862; P:negative regulation of muscle tissue development; IMP:BHF-UCL.
GO; GO:0045668; P:negative regulation of osteoblast differentiation; IGI:MGI.
GO; GO:1904205; P:negative regulation of skeletal muscle hypertrophy; IMP:BHF-UCL.
GO; GO:0014912; P:negative regulation of smooth muscle cell migration; ISO:MGI.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0017148; P:negative regulation of translation; ISO:MGI.
GO; GO:0001649; P:osteoblast differentiation; IEP:BHF-UCL.
GO; GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IGI:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IMP:MGI.
GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; ISO:MGI.
GO; GO:1904707; P:positive regulation of vascular smooth muscle cell proliferation; ISO:MGI.
GO; GO:0001558; P:regulation of cell growth; IGI:MGI.
GO; GO:0010906; P:regulation of glucose metabolic process; IGI:MGI.
GO; GO:0040008; P:regulation of growth; IGI:MGI.
GO; GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; TAS:BHF-UCL.
GO; GO:0060416; P:response to growth hormone; ISS:AgBase.
GO; GO:0051146; P:striated muscle cell differentiation; IMP:MGI.
GO; GO:0044342; P:type B pancreatic cell proliferation; IGI:MGI.
CDD; cd00191; TY; 1.
Gene3D; 4.10.800.10; -; 1.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR012213; IGFBP-5.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR009168; IGFBP1-6.
InterPro; IPR022321; IGFBP_1-6_chordata.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000716; Thyroglobulin_1.
InterPro; IPR036857; Thyroglobulin_1_sf.
PANTHER; PTHR11551; PTHR11551; 1.
PANTHER; PTHR11551:SF4; PTHR11551:SF4; 1.
Pfam; PF00219; IGFBP; 1.
Pfam; PF00086; Thyroglobulin_1; 1.
PRINTS; PR01976; IGFBPFAMILY.
PRINTS; PR01981; IGFBPFAMILY5.
SMART; SM00121; IB; 1.
SMART; SM00211; TY; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF57610; SSF57610; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Growth factor binding; Phosphoprotein; Reference proteome; Secreted;
Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 271 Insulin-like growth factor-binding
protein 5.
/FTId=PRO_0000014386.
DOMAIN 22 102 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 188 262 Thyroglobulin type-1.
{ECO:0000255|PROSITE-ProRule:PRU00500}.
MOD_RES 115 115 Phosphoserine.
{ECO:0000250|UniProtKB:P24593}.
DISULFID 44 58 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 66 79 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 191 218 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 229 240 {ECO:0000255|PROSITE-ProRule:PRU00500}.
DISULFID 242 262 {ECO:0000255|PROSITE-ProRule:PRU00500}.
CONFLICT 112 112 Missing (in Ref. 2; AAC01750).
{ECO:0000305}.
SEQUENCE 271 AA; 30372 MW; F55A58729861F6F0 CRC64;
MVISVVLLLL AAYAVPAQGL GSFVHCEPCD EKALSMCPPS PLGCELVKEP GCGCCMTCAL
AEGQSCGVYT ERCAQGLRCL PRQDEEKPLH ALLHGRGVCL NEKSYGEQTK IERDSREHEE
PTTSEMAEET YSPKVFRPKH TRISELKAEA VKKDRRKKLT QSKFVGGAEN TAHPRVIPAP
EMRQESEQGP CRRHMEASLQ EFKASPRMVP RAVYLPNCDR KGFYKRKQCK PSRGRKRGIC
WCVDKYGMKL PGMEYVDGDF QCHAFDSSNV E


Related products :

Catalog number Product name Quantity
20-783-72936 MOUSE ANTI HUMAN INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 - INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 3; IGFBP-3; IBP-3; IGF-binding protein 3 Monoclonal 0.2 mg
E0053m ELISA IBP-2,IGF-binding protein 2,Igfbp2,IGFBP-2,Igfbp-2,Insulin-like growth factor-binding protein 2,mIGFBP-2,Mouse,Mus musculus 96T
U0053m CLIA IBP-2,IGF-binding protein 2,Igfbp2,IGFBP-2,Igfbp-2,Insulin-like growth factor-binding protein 2,mIGFBP-2,Mouse,Mus musculus 96T
E0053m ELISA kit IBP-2,IGF-binding protein 2,Igfbp2,IGFBP-2,Igfbp-2,Insulin-like growth factor-binding protein 2,mIGFBP-2,Mouse,Mus musculus 96T
U0052r CLIA IBP-1,IGF-binding protein 1,Igfbp1,IGFBP-1,Igfbp-1,Insulin-like growth factor-binding protein 1,Rat,Rattus norvegicus 96T
E0055m ELISA IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Mouse,Mus musculus 96T
E0054r ELISA IBP-3,IGF-binding protein 3,Igfbp3,IGFBP-3,Igfbp-3,Insulin-like growth factor-binding protein 3,Rat,Rattus norvegicus 96T
U0052m CLIA IBP-1,IGF-binding protein 1,Igfbp1,IGFBP-1,Igfbp-1,Insulin-like growth factor-binding protein 1,Mouse,Mus musculus 96T
U0055r CLIA IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Rat,Rattus norvegicus 96T
E0274m ELISA kit IBP-6,IGF-binding protein 6,Igfbp6,IGFBP-6,Igfbp-6,Insulin-like growth factor-binding protein 6,Mouse,Mus musculus 96T
E0274r ELISA kit IBP-6,IGF-binding protein 6,Igfbp6,IGFBP-6,Igfbp-6,Insulin-like growth factor-binding protein 6,Rat,Rattus norvegicus 96T
E0055r ELISA IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Rat,Rattus norvegicus 96T
E0055r ELISA kit IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Rat,Rattus norvegicus 96T
E0055m ELISA kit IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Mouse,Mus musculus 96T
E0052m ELISA IBP-1,IGF-binding protein 1,Igfbp1,IGFBP-1,Igfbp-1,Insulin-like growth factor-binding protein 1,Mouse,Mus musculus 96T
E0052r ELISA IBP-1,IGF-binding protein 1,Igfbp1,IGFBP-1,Igfbp-1,Insulin-like growth factor-binding protein 1,Rat,Rattus norvegicus 96T
E0054m ELISA kit IBP-3,IGF-binding protein 3,Igfbp3,IGFBP-3,Igfbp-3,Insulin-like growth factor-binding protein 3,Mouse,Mus musculus 96T
U0055m CLIA IBP-4,IGF-binding protein 4,Igfbp4,IGFBP-4,Igfbp-4,Insulin-like growth factor-binding protein 4,Mouse,Mus musculus 96T
E0054r ELISA kit IBP-3,IGF-binding protein 3,Igfbp3,IGFBP-3,Igfbp-3,Insulin-like growth factor-binding protein 3,Rat,Rattus norvegicus 96T
U0274m CLIA IBP-6,IGF-binding protein 6,Igfbp6,IGFBP-6,Igfbp-6,Insulin-like growth factor-binding protein 6,Mouse,Mus musculus 96T
U0274r CLIA IBP-6,IGF-binding protein 6,Igfbp6,IGFBP-6,Igfbp-6,Insulin-like growth factor-binding protein 6,Rat,Rattus norvegicus 96T
E0054m ELISA IBP-3,IGF-binding protein 3,Igfbp3,IGFBP-3,Igfbp-3,Insulin-like growth factor-binding protein 3,Mouse,Mus musculus 96T
E0052m ELISA kit IBP-1,IGF-binding protein 1,Igfbp1,IGFBP-1,Igfbp-1,Insulin-like growth factor-binding protein 1,Mouse,Mus musculus 96T
E0274r ELISA IBP-6,IGF-binding protein 6,Igfbp6,IGFBP-6,Igfbp-6,Insulin-like growth factor-binding protein 6,Rat,Rattus norvegicus 96T
U0054m CLIA IBP-3,IGF-binding protein 3,Igfbp3,IGFBP-3,Igfbp-3,Insulin-like growth factor-binding protein 3,Mouse,Mus musculus 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur