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Insulin-like receptor

 C7C418_DROSI            Unreviewed;      2153 AA.
C7C418;
22-SEP-2009, integrated into UniProtKB/TrEMBL.
22-SEP-2009, sequence version 1.
23-MAY-2018, entry version 60.
SubName: Full=Insulin-like receptor {ECO:0000313|EMBL:CAY93033.1};
Name=inr {ECO:0000313|EMBL:CAY93033.1};
Drosophila simulans (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7240 {ECO:0000313|EMBL:CAY93033.1};
[1] {ECO:0000313|EMBL:CAY93033.1}
NUCLEOTIDE SEQUENCE.
STRAIN=SAL_20 {ECO:0000313|EMBL:CAY93033.1};
Guirao-Rico S., Aguade M.;
"Positive selection has driven the evolution of the Drosophila
Insulin-like Receptor (InR) at different time scales.";
Mol. Biol. Evol. 26:1723-1732(2009).
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00701269}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
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EMBL; FN394662; CAY93033.1; -; Genomic_DNA.
ChiTaRS; InR; fly.
GO; GO:0005899; C:insulin receptor complex; IEA:EnsemblMetazoa.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:EnsemblMetazoa.
GO; GO:0043559; F:insulin binding; IEA:EnsemblMetazoa.
GO; GO:0005009; F:insulin-activated receptor activity; IEA:EnsemblMetazoa.
GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
GO; GO:0005975; P:carbohydrate metabolic process; IEA:EnsemblMetazoa.
GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
GO; GO:0042632; P:cholesterol homeostasis; IEA:EnsemblMetazoa.
GO; GO:0007623; P:circadian rhythm; IEA:EnsemblMetazoa.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0055116; P:entry into reproductive diapause; IEA:EnsemblMetazoa.
GO; GO:0048132; P:female germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
GO; GO:0008585; P:female gonad development; IEA:EnsemblMetazoa.
GO; GO:0060180; P:female mating behavior; IEA:EnsemblMetazoa.
GO; GO:0007390; P:germ-band shortening; IEA:EnsemblMetazoa.
GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
GO; GO:0007446; P:imaginal disc growth; IEA:EnsemblMetazoa.
GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:EnsemblMetazoa.
GO; GO:0006629; P:lipid metabolic process; IEA:EnsemblMetazoa.
GO; GO:0007626; P:locomotory behavior; IEA:EnsemblMetazoa.
GO; GO:0048133; P:male germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
GO; GO:0035264; P:multicellular organism growth; IEA:EnsemblMetazoa.
GO; GO:0007520; P:myoblast fusion; IEA:EnsemblMetazoa.
GO; GO:0010507; P:negative regulation of autophagy; IEA:EnsemblMetazoa.
GO; GO:0042321; P:negative regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
GO; GO:2000252; P:negative regulation of feeding behavior; IEA:EnsemblMetazoa.
GO; GO:0090278; P:negative regulation of peptide hormone secretion; IEA:EnsemblMetazoa.
GO; GO:0030707; P:ovarian follicle cell development; IEA:EnsemblMetazoa.
GO; GO:0030307; P:positive regulation of cell growth; IEA:EnsemblMetazoa.
GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
GO; GO:0070346; P:positive regulation of fat cell proliferation; IEA:EnsemblMetazoa.
GO; GO:0010884; P:positive regulation of lipid storage; IEA:EnsemblMetazoa.
GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
GO; GO:1904801; P:positive regulation of neuron remodeling; IEA:EnsemblMetazoa.
GO; GO:0046622; P:positive regulation of organ growth; IEA:EnsemblMetazoa.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:EnsemblMetazoa.
GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:EnsemblMetazoa.
GO; GO:0007285; P:primary spermatocyte growth; IEA:EnsemblMetazoa.
GO; GO:0046777; P:protein autophosphorylation; IEA:EnsemblMetazoa.
GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:EnsemblMetazoa.
GO; GO:0034059; P:response to anoxia; IEA:EnsemblMetazoa.
GO; GO:0042220; P:response to cocaine; IEA:EnsemblMetazoa.
GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa.
GO; GO:0007525; P:somatic muscle development; IEA:EnsemblMetazoa.
GO; GO:0070328; P:triglyceride homeostasis; IEA:EnsemblMetazoa.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
Gene3D; 3.80.20.20; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR006211; Furin-like_Cys-rich_dom.
InterPro; IPR006212; Furin_repeat.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR000494; Rcpt_L-dom.
InterPro; IPR036941; Rcpt_L-dom_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam; PF00757; Furin-like; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF01030; Recep_L_domain; 2.
PRINTS; PR00109; TYRKINASE.
SMART; SM00060; FN3; 3.
SMART; SM00261; FU; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF49265; SSF49265; 3.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS00708816};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|SAAS:SAAS00600436, ECO:0000313|EMBL:CAY93033.1};
Repeat {ECO:0000256|SAAS:SAAS00786331};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
TRANSMEM 154 172 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 275 299 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 834 936 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 1219 1314 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 1380 1668 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
SEQUENCE 2153 AA; 241059 MW; EABD6EA425F4565D CRC64;
MFNMPRGVTK SKSKRGKIKM ENDMAAATTT TTTTACTLGH ICVLCRQEML LDTCCCRQAV
EAVDSPASSD EAYSSSTSNC QASSEISAEK VWFLSHDDIV LCRRPKFDEV ETTGKKRDVK
CRGHQCSNEC DDGSTKNNRH QREKFNIFSN CHNILRTLQS LLLLMFNCGI FNKRRRRQHQ
QQQHHHQQQQ HHHQHHPQQH QHHQQHHQRQ QAHVSYTKFL LLLQTLAAAT TRLSLSPKNY
NQQQLQHNQQ LPRATPQQKQ QEKDRHKCFH YKHNYYYTPG ISLLLFILLA NTLAIQAVVL
PAHQQHLLHN DIADGLDKTA LSVSGTQSRW PRSESNPTMR LSQNVKPCKS MDIRNMVSHF
NQLENCTVIE GFLLIDLIND ASPLNRSFPK LTEVTDYIII YRVTGLHSLS KIFPNLSVIR
GNKLFDGYAL VVYSNFDLMD LGLHKLRSIT RGGVRIEKNH KLCYDRTIDW LEILAENETQ
LVVLTENGKE KECRLSKCPG EIRIEEGHDS TAIEGELNAS CQLHNNRRLC WNSKLCQTKC
PEKCRNNCID EHTCCSQDCL GGCVIDKHGN ESCISCRNVS FNNICMDSCP KGYFQFDSRC
VTANECTTLT KFETNSVYSG IPYNGQCITH CPTGYQKSEN KRMCEPCPGG KCDKECSSGL
IDSLERAREF HGCTIITGTE PLTISIKRES GAHVMDELKY GLAAVHKIQS SLMVHLTYGL
KSLKFFQSLT EISGDPPMDA DKYALYVLDN RDLDELWGPN QTVFIRKGGV FFHFNPKLCV
STINQLLPML ASKPKFFEKS DVGADSNGNR GSCGTAVLNV TLQSVGANSA LLNVTTKVEI
GEPQKPSNAT IIFKDPRAFI GFVFYHMIDP YGNSTKSSDD PCDDRWKVSS PEKSGVMVLS
NLIPYTNYSY YVRTMAISSE LTNAESDVKN FRTNPGRPSK VTEVVATAIS DSKINVTWSY
LDKPYGVLTR YFIKAKLINR PTRNNNRDYC TEPLIKAMEN DLPATTPTKK IPDPLAGDCK
CVEGSKKTSS QEYDDRKVQA GMEFENALQN FIFVPNIRKS KNGSSDKSDG AEGAALDSNA
IPNGGASNPS RRRRDVALEP ELDDVEGSVL LRHVRSITDD TDAFFEKDDE NTYKDEEDLS
SNKQFYEVFA KELPPNQTHF VFEKLRHFTR YAIFVVACRE EIPSEKLRDT SFKKSLCSDY
DTVFQTTKRK KFADIVMDLK VDLEHANNTE SPVRVRWTPP VDPNGEIVTY EVAYKLQKPD
QVEEKKCIPA ADFNQTAGYL IKLNEGLYSF RVRANSIAGY GDFTEVEHIK VEPPPSYAKV
FFWLLGIGLS LLIVSLFGYV CYLHKRKVPS NDLHMNTEVN PFYASMQYIP DDWEVLRENI
IQLAPLGQGS FGMVYEGILK SFPPNGLDRE CAIKTVNENA TDRERTNFLS EASVMKEFDT
YHVVRLLGVC SRGQPALVVM ELMKKGDLKS YLRAHRPEER DEAMITYLNR IGVTGNVQPP
TYGRIYQMAI EIADGMAYLA AKKFVHRDLA ARNCMVADDL TVKIGDFGMT RDIYETDYYR
KGTKGLLPVR WMPPESLRDG VYSSASDVFS FGVVLWEMAT LAAQPYQGLS NEQVLRYVID
GGVMERPENC PDFLHKLMQR CWHHRSSARP SFLDIIAYLE PQCPNSQFKE VSFYHSEAGL
QHREKERKER NQLDAFAAVP LDQDLQEREQ QEDATTPLRM GDYQQNSSLD QPPESPIAMV
DDQGSHLPFS LPSGFIASST PDGQTLMPTA FHNIPAGQGD ISSAYVVPDT DALDGDRGYE
IYDPSPKCAE LPTSRSGSTG GGKLSGEQHL LPRKGRQPTI MSSSMPDDVI GGSSLQPSTA
SAASSNGSSH TGRPSLKKTV ADSVRNKANF INRHLFNHKR TGSNASHKSN ASNAPSTSSN
TNLTSHPVAM GNLGTIESGG SGSAGSYTGT PRFYTPSATP GGGSGMAISD NPNYRLLDES
IASEQATILT TSSPNPNYEM MHPPTSLVST NPNYMPMNET PVQMAGVTIS HNPNYQPMQA
PLNARQSQSS SDEDNEQDED DEDEDDDVDD EHVEHIKMER MPLSRPRQRA LPSKTQPPRS
RSVSQTRKSP TNPNSGVGAT GAGNRSNLLK ENWLRPASTP RPPPPNGFIG REA


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