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Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (CD antigen CD11b)

 ITAM_MOUSE              Reviewed;        1153 AA.
P05555; Q8CA73;
01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 2.
20-JUN-2018, entry version 165.
RecName: Full=Integrin alpha-M;
AltName: Full=CD11 antigen-like family member B;
AltName: Full=CR-3 alpha chain;
AltName: Full=Cell surface glycoprotein MAC-1 subunit alpha;
AltName: Full=Leukocyte adhesion receptor MO1;
AltName: CD_antigen=CD11b;
Flags: Precursor;
Name=Itgam;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=3044779;
Pytela R.;
"Amino acid sequence of the murine Mac-1 alpha chain reveals homology
with the integrin family and an additional domain related to von
Willebrand factor.";
EMBO J. 7:1371-1378(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6J; TISSUE=Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-45.
STRAIN=BALB/cJ; TISSUE=Spleen;
PubMed=2942940; DOI=10.1073/pnas.83.15.5644;
Sastre L., Roman J.M., Teplow D.B., Dreyer W.J., Gee C.E.,
Larson R.S., Roberts T.M., Springer T.A.;
"A partial genomic DNA clone for the alpha subunit of the mouse
complement receptor type 3 and cellular adhesion molecule Mac-1.";
Proc. Natl. Acad. Sci. U.S.A. 83:5644-5648(1986).
[4]
PROTEIN SEQUENCE OF 17-28, AND TISSUE SPECIFICITY.
PubMed=3887182; DOI=10.1038/314540a0;
Springer T.A., Teplow D.B., Dreyer W.J.;
"Sequence homology of the LFA-1 and Mac-1 leukocyte adhesion
glycoproteins and unexpected relation to leukocyte interferon.";
Nature 314:540-542(1985).
[5]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=8986723;
Coxon A., Rieu P., Barkalow F.J., Askari S., Sharpe A.H.,
von Andrian U.H., Arnaout M.A., Mayadas T.N.;
"A novel role for the beta 2 integrin CD11b/CD18 in neutrophil
apoptosis: a homeostatic mechanism in inflammation.";
Immunity 5:653-666(1996).
[6]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=9382884;
Tang T., Rosenkranz A., Assmann K.J., Goodman M.J.,
Gutierrez-Ramos J.C., Carroll M.C., Cotran R.S., Mayadas T.N.;
"A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil
function in vivo: Mac-1 deficiency abrogates sustained Fcgamma
receptor-dependent neutrophil adhesion and complement-dependent
proteinuria in acute glomerulonephritis.";
J. Exp. Med. 186:1853-1863(1997).
[7]
DISRUPTION PHENOTYPE.
PubMed=9207125;
Dong Z.M., Gutierrez-Ramos J.C., Coxon A., Mayadas T.N., Wagner D.D.;
"A new class of obesity genes encodes leukocyte adhesion receptors.";
Proc. Natl. Acad. Sci. U.S.A. 94:7526-7530(1997).
[8]
FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
PHENOTYPE.
PubMed=9862668;
Rosenkranz A.R., Coxon A., Maurer M., Gurish M.F., Austen K.F.,
Friend D.S., Galli S.J., Mayadas T.N.;
"Impaired mast cell development and innate immunity in Mac-1
(CD11b/CD18, CR3)-deficient mice.";
J. Immunol. 161:6463-6467(1998).
[9]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Integrin ITGAM/ITGB2 is implicated in various adhesive
interactions of monocytes, macrophages and granulocytes as well as
in mediating the uptake of complement-coated particles. It is
identical with CR-3, the receptor for the iC3b fragment of the
third complement component. It probably recognizes the R-G-D
peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for
fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides
of fibrinogen gamma chain. Regulates neutrophil migration
(PubMed:8986723, PubMed:9382884, PubMed:9862668). In association
with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated
activation of TNF primed neutrophils (By similarity). May regulate
phagocytosis-induced apoptosis in extravasated neutrophils
(PubMed:8986723). May play a role in mast cell development
(PubMed:9862668). {ECO:0000250|UniProtKB:P11215,
ECO:0000269|PubMed:8986723, ECO:0000269|PubMed:9382884,
ECO:0000269|PubMed:9862668}.
-!- SUBUNIT: Heterodimer of an alpha and a beta chain. ITGAM
associates with ITGB2. Found in a complex with CD177 and
ITGB2/CD18. Interacts with JAM3. Interacts with THBD.
{ECO:0000250|UniProtKB:P11215}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9862668}; Single-pass type I membrane protein
{ECO:0000250|UniProtKB:P11215}. Membrane raft
{ECO:0000250|UniProtKB:P11215}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P11215}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P05555-1; Sequence=Displayed;
Name=2;
IsoId=P05555-2; Sequence=VSP_010473;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Predominantly expressed in monocytes and
granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a
subset of peritoneal mast cells (PubMed:9862668).
{ECO:0000269|PubMed:3887182, ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9862668}.
-!- INDUCTION: Induced by lipopolysaccharide (LPS) in mast cells.
{ECO:0000269|PubMed:9862668}.
-!- DOMAIN: The integrin I-domain (insert) is a VWFA domain. Integrins
with I-domains do not undergo protease cleavage.
-!- DISRUPTION PHENOTYPE: Mice are born at the expected Mendelian rate
(PubMed:8986723). The numbers of blood leukocytes are normal and
neutrophils rolling on blood vessels is not affected
(PubMed:8986723). Impaired LTB4-induced neutrophil adhesion to
venules (PubMed:8986723). Numbers of mast cells in the peritoneal
cavity, peritoneal wall and in the dorsal skin are reduced
(PubMed:9862668). In an experimental model of thioglycolate-
induced peritonitis, abnormal accumulation of recruited
neutrophils due to impaired apoptosis (PubMed:8986723). In an
experimental model of acute septic peritonitis, 5-fold increase in
mortality rate, reduced neutrophil recruitment in the peritoneum,
reduced histamine production and impaired bacterial clearence
(PubMed:9862668). In experimental model of immune complex-mediated
glomerulonephritis, reduced neutrophil accumulation without
affecting their initial recruitment and reduced proteinuria
(PubMed:9382884). Enhanced susceptibility to high fat diet-induced
obesity characterized by a weight increase and higher levels of
white and brown fat (PubMed:9207125). {ECO:0000269|PubMed:8986723,
ECO:0000269|PubMed:9207125, ECO:0000269|PubMed:9382884,
ECO:0000269|PubMed:9862668}.
-!- SIMILARITY: Belongs to the integrin alpha chain family.
{ECO:0000305}.
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EMBL; X07640; CAA30479.1; -; mRNA.
EMBL; AK039444; BAC30350.1; -; mRNA.
EMBL; M14293; AAA39484.1; -; Genomic_DNA.
CCDS; CCDS21889.1; -. [P05555-1]
PIR; S00551; S00551.
UniGene; Mm.262106; -.
ProteinModelPortal; P05555; -.
SMR; P05555; -.
ComplexPortal; CPX-3129; Integrin alphaM-beta2 complex.
IntAct; P05555; 2.
MINT; P05555; -.
STRING; 10090.ENSMUSP00000101849; -.
ChEMBL; CHEMBL3603; -.
PhosphoSitePlus; P05555; -.
MaxQB; P05555; -.
PaxDb; P05555; -.
PeptideAtlas; P05555; -.
PRIDE; P05555; -.
MGI; MGI:96607; Itgam.
eggNOG; ENOG410IPBA; Eukaryota.
eggNOG; ENOG410ZFBE; LUCA.
HOGENOM; HOG000113114; -.
HOVERGEN; HBG100530; -.
InParanoid; P05555; -.
PhylomeDB; P05555; -.
ChiTaRS; Itgam; mouse.
PRO; PR:P05555; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_ITGAM; -.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IDA:MGI.
GO; GO:0008305; C:integrin complex; IEA:InterPro.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0044853; C:plasma membrane raft; ISO:MGI.
GO; GO:0001851; F:complement component C3b binding; IGI:ARUK-UCL.
GO; GO:0031072; F:heat shock protein binding; ISO:MGI.
GO; GO:0043395; F:heparan sulfate proteoglycan binding; IDA:MGI.
GO; GO:0008201; F:heparin binding; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0001846; F:opsonin binding; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0050798; P:activated T cell proliferation; IMP:MGI.
GO; GO:0097242; P:amyloid-beta clearance; IMP:ARUK-UCL.
GO; GO:0007155; P:cell adhesion; IMP:MGI.
GO; GO:0098609; P:cell-cell adhesion; IGI:MGI.
GO; GO:0045123; P:cellular extravasation; IMP:MGI.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0061756; P:leukocyte adhesion to vascular endothelial cell; IMP:UniProtKB.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IMP:MGI.
GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IMP:MGI.
GO; GO:0014005; P:microglia development; IDA:MGI.
GO; GO:0001774; P:microglial cell activation; IMP:ARUK-UCL.
GO; GO:0045963; P:negative regulation of dopamine metabolic process; IDA:ARUK-UCL.
GO; GO:0001781; P:neutrophil apoptotic process; IMP:UniProtKB.
GO; GO:0030593; P:neutrophil chemotaxis; IMP:MGI.
GO; GO:0006909; P:phagocytosis; IMP:UniProtKB.
GO; GO:0006911; P:phagocytosis, engulfment; IMP:ARUK-UCL.
GO; GO:0060376; P:positive regulation of mast cell differentiation; IMP:UniProtKB.
GO; GO:1903980; P:positive regulation of microglial cell activation; IMP:ARUK-UCL.
GO; GO:1901216; P:positive regulation of neuron death; IMP:ARUK-UCL.
GO; GO:0043315; P:positive regulation of neutrophil degranulation; ISO:MGI.
GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; IMP:ARUK-UCL.
GO; GO:2000363; P:positive regulation of prostaglandin-E synthase activity; IMP:ARUK-UCL.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; IMP:ARUK-UCL.
GO; GO:0032930; P:positive regulation of superoxide anion generation; IMP:ARUK-UCL.
Gene3D; 2.130.10.130; -; 2.
Gene3D; 3.40.50.410; -; 1.
InterPro; IPR013517; FG-GAP.
InterPro; IPR013519; Int_alpha_beta-p.
InterPro; IPR000413; Integrin_alpha.
InterPro; IPR013649; Integrin_alpha-2.
InterPro; IPR018184; Integrin_alpha_C_CS.
InterPro; IPR028994; Integrin_alpha_N.
InterPro; IPR032695; Integrin_dom_sf.
InterPro; IPR002035; VWF_A.
InterPro; IPR036465; vWFA_dom_sf.
Pfam; PF01839; FG-GAP; 1.
Pfam; PF00357; Integrin_alpha; 1.
Pfam; PF08441; Integrin_alpha2; 1.
Pfam; PF00092; VWA; 1.
PRINTS; PR01185; INTEGRINA.
SMART; SM00191; Int_alpha; 5.
SMART; SM00327; VWA; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF69179; SSF69179; 3.
PROSITE; PS51470; FG_GAP; 7.
PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PROSITE; PS50234; VWFA; 1.
1: Evidence at protein level;
Alternative splicing; Calcium; Cell adhesion; Cell membrane;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Integrin; Membrane; Metal-binding; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 16 {ECO:0000269|PubMed:3887182}.
CHAIN 17 1153 Integrin alpha-M.
/FTId=PRO_0000016290.
TOPO_DOM 17 1105 Extracellular. {ECO:0000255}.
TRANSMEM 1106 1129 Helical. {ECO:0000255}.
TOPO_DOM 1130 1153 Cytoplasmic. {ECO:0000255}.
REPEAT 18 75 FG-GAP 1. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 76 135 FG-GAP 2. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
DOMAIN 164 338 VWFA. {ECO:0000255|PROSITE-
ProRule:PRU00219}.
REPEAT 339 390 FG-GAP 3. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 391 442 FG-GAP 4. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 443 503 FG-GAP 5. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 506 564 FG-GAP 6. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
REPEAT 569 629 FG-GAP 7. {ECO:0000255|PROSITE-
ProRule:PRU00803}.
CA_BIND 465 473 {ECO:0000255}.
CA_BIND 529 537 {ECO:0000255}.
CA_BIND 592 600 {ECO:0000255}.
MOTIF 1132 1136 GFFKR motif.
CARBOHYD 58 58 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 86 86 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 391 391 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 696 696 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 734 734 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 772 772 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 801 801 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 881 881 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 907 907 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 941 941 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 980 980 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 994 994 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1022 1022 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1045 1045 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1051 1051 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1076 1076 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 66 73 {ECO:0000250}.
DISULFID 105 123 {ECO:0000250}.
DISULFID 654 711 {ECO:0000250}.
DISULFID 770 776 {ECO:0000250}.
DISULFID 999 1023 {ECO:0000250}.
DISULFID 1028 1033 {ECO:0000250}.
VAR_SEQ 453 569 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_010473.
CONFLICT 37 37 N -> S (in Ref. 2; BAC30350).
{ECO:0000305}.
CONFLICT 683 683 V -> G (in Ref. 2; BAC30350).
{ECO:0000305}.
SEQUENCE 1153 AA; 127481 MW; 178DB988AECB0343 CRC64;
MTLKALLVTA LALCHGFNLD TEHPMTFQEN AKGFGQNVVQ LGGTSVVVAA PQEAKAVNQT
GALYQCDYST SRCHPIPLQV PPEAVNMSLG LSLAVSTVPQ QLLACGPTVH QNCKENTYVN
GLCYLFGSNL LRPPQQFPEA LRECPQQESD IVFLIDGSGS INNIDFQKMK EFVSTVMEQF
KKSKTLFSLM QYSDEFRIHF TFNDFKRNPS PRSHVSPIKQ LNGRTKTASG IRKVVRELFH
KTNGARENAA KILVVITDGE KFGDPLDYKD VIPEADRAGV IRYVIGVGNA FNKPQSRREL
DTIASKPAGE HVFQVDNFEA LNTIQNQLQE KIFAIEGTQT GSTSSFEHEM SQEGFSASIT
SNGPLLGSVG SFDWAGGAFL YTSKDKVTFI NTTRVDSDMN DAYLGYASAV ILRNRVQSLV
LGAPRYQHIG LVVMFRENFG TWEPHTSIKG SQIGSYFGAS LCSVDMDADG NTNLILIGAP
HYYEKTRGGQ VSVCPLPRGR ARWQCEALLH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI
GAPGEQENQG AVYIFYGASI ASLSASHSHR IIGAHFSPGL QYFGQSLSGG KDLTMDGLMD
LAVGAQGHLL LLRAQPVLRL EATMEFSPKK VARSVFACQE QVLKNKDAGE VRVCLRVRKN
TKDRLREGDI QSTVTYDLAL DPVRSRIRAF FDETKNNTRR RTQVFGLMQK CETLKLILPD
CVDDSVSPII LRLNYTLVGE PLRSFGNLRP VLAMDAQRFF TAMFPFEKNC GNDSICQDDL
SITMSAMGLD TLVVGGPQDF NMSVTLRNDG EDSYGTQVTV YYPSGLSYRK DSASQNPLTK
KPWFVKPAES SSSSEGHGAL KSTTWNINHP IFPANSEVTF NVTFDVDSHA SFGNKLLLKA
IVASENNMSR THKTKFQLEL PVKYAIYMIV TSDESSIRYL NFTASEMTSK VIQHQYQFNN
LGQRSLPVSV VFWIPVQINN VTVWDHPQVI FSQNLSSACH TEQKSPPHSN FRDQLERTPV
LNCSVAVCKR IQCDLPSFNT QEIFNVTLKG NLSFDWYIKT SHGHLLLVSS TEILFNDSAF
ALLPGQESYV RSKTETKVEP YEVHNPVPLI VGSSIGGLVL LALITAGLYK LGFFKRQYKD
MMNEAAPQDA PPQ


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20-783-72303 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.02 mg
20-783-72301 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.1 mg
20-783-72298 MOUSE ANTI HUMAN CD11b - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen M 0.2 mg
20-272-191997 Integrin alpha M - Mouse monoclonal [ICRF 44] to Integrin alpha M; Cell surface glycoprotein MAC-1 alpha subunit; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11 0.2 mg
E1572m ELISA kit CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymp 96T
U1572m CLIA CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymphocyte 96T
E1572m ELISA CD11 antigen-like family member A,Integrin alpha-L,Itgal,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,Lfa-1,LFA-1A,Ly-15,Ly-15,Lymphocyt 96T
E1572b ELISA Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572b ELISA kit Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
U1572b CLIA Bos taurus,Bovine,CD11 antigen-like family member A,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572h ELISA CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
E1572h ELISA kit CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA- 96T
U1572h CLIA CD11 antigen-like family member A,CD11A,Homo sapiens,Human,Integrin alpha-L,ITGAL,Leukocyte adhesion glycoprotein LFA-1 alpha chain,Leukocyte function-associated molecule 1 alpha chain,LFA-1A 96T
20-783-72299 MOUSE ANTI HUMAN CD11b Biotin - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b an 0.1 mg
20-783-72302 MOUSE ANTI HUMAN CD11b RPE - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antig 100 TESTS
20-783-72300 MOUSE ANTI HUMAN CD11b FITC - INTEGRIN ALPHA M CHAIN. MAC-1; Cell surface glycoprotein MAC-1 subunit alpha; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b anti 0.1 mg
20-272-190178 CD11b - Mouse monoclonal [LT11] to CD11b; Cell surface glycoprotein MAC-1 alpha subunit; CR-3 alpha chain; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b antigen Monoclonal 0.1 mg


 

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