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Integrin beta

 A8DSD5_PIG              Unreviewed;       769 AA.
A8DSD5;
13-NOV-2007, integrated into UniProtKB/TrEMBL.
13-NOV-2007, sequence version 1.
12-SEP-2018, entry version 87.
RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
Name=ITGB2 {ECO:0000313|Ensembl:ENSSSCP00000028146};
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823 {ECO:0000313|EMBL:ABU86738.1};
[1] {ECO:0000313|EMBL:ABU86738.1}
NUCLEOTIDE SEQUENCE.
STRAIN=WbCD18 {ECO:0000313|EMBL:ABU86738.1};
TISSUE=Spleen {ECO:0000313|EMBL:ABU86738.1};
PubMed=17937788; DOI=10.1186/1746-6148-3-27;
Bergh P.G., Zecchinon L.L., Fett T., Desmecht D.J.;
"The wild boar (Sus scrofa) lymphocyte function-associated antigen-1
(CD11a/CD18) receptor: cDNA sequencing, structure analysis and
comparison with homologues.";
BMC Vet. Res. 3:27-27(2007).
[2] {ECO:0000313|EMBL:ABU86738.1}
NUCLEOTIDE SEQUENCE.
STRAIN=WbCD18 {ECO:0000313|EMBL:ABU86738.1};
TISSUE=Spleen {ECO:0000313|EMBL:ABU86738.1};
Vanden Bergh P.G.A.C., Zecchinon L.L.M., Fett T., Desmecht D.J.M.;
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSSSCP00000028146, ECO:0000313|Proteomes:UP000008227}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000028146};
Porcine genome sequencing project;
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSSSCP00000028146}
IDENTIFICATION.
Ensembl;
Submitted (MAY-2012) to UniProtKB.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
Single-pass type I membrane protein
{ECO:0000256|RuleBase:RU000633}.
-!- SIMILARITY: Belongs to the integrin beta chain family.
{ECO:0000256|RuleBase:RU000633}.
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EMBL; AEMK02000093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF585977; ABU86738.1; -; mRNA.
UniGene; Ssc.14561; -.
PRIDE; A8DSD5; -.
Ensembl; ENSSSCT00000029647; ENSSSCP00000028146; ENSSSCG00000025133.
eggNOG; KOG1226; Eukaryota.
eggNOG; ENOG410XP60; LUCA.
GeneTree; ENSGT00760000119064; -.
HOVERGEN; HBG006190; -.
OMA; RGRCRCN; -.
OrthoDB; EOG091G029W; -.
TreeFam; TF105392; -.
Reactome; R-SSC-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-SSC-202733; Cell surface interactions at the vascular wall.
Reactome; R-SSC-216083; Integrin cell surface interactions.
Reactome; R-SSC-6798695; Neutrophil degranulation.
Proteomes; UP000008227; Chromosome 13.
Bgee; ENSSSCG00000025133; Expressed in 6 organ(s), highest expression level in lung.
GO; GO:0008305; C:integrin complex; IEA:InterPro.
GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
GO; GO:0007229; P:integrin-mediated signaling pathway; IMP:AgBase.
GO; GO:0050766; P:positive regulation of phagocytosis; IMP:AgBase.
Gene3D; 1.20.5.630; -; 1.
Gene3D; 3.40.50.410; -; 1.
InterPro; IPR033760; Integrin_beta_N.
InterPro; IPR015812; Integrin_bsu.
InterPro; IPR015439; Integrin_bsu-2.
InterPro; IPR014836; Integrin_bsu_cyt_dom.
InterPro; IPR037076; Integrin_bsu_cyt_dom_sf.
InterPro; IPR012896; Integrin_bsu_tail.
InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
InterPro; IPR002369; Integrin_bsu_VWA.
InterPro; IPR032695; Integrin_dom_sf.
InterPro; IPR016201; PSI.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR10082; PTHR10082; 1.
PANTHER; PTHR10082:SF15; PTHR10082:SF15; 1.
Pfam; PF08725; Integrin_b_cyt; 1.
Pfam; PF07965; Integrin_B_tail; 1.
Pfam; PF00362; Integrin_beta; 1.
Pfam; PF17205; PSI_integrin; 1.
PIRSF; PIRSF002512; Integrin_B; 1.
PRINTS; PR01186; INTEGRINB.
SMART; SM00187; INB; 1.
SMART; SM01241; Integrin_b_cyt; 1.
SMART; SM01242; Integrin_B_tail; 1.
SMART; SM00423; PSI; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF69179; SSF69179; 1.
SUPFAM; SSF69687; SSF69687; 1.
PROSITE; PS00243; INTEGRIN_BETA; 1.
1: Evidence at protein level;
Cell adhesion {ECO:0000256|RuleBase:RU000633};
Complete proteome {ECO:0000313|Proteomes:UP000008227};
Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
Integrin {ECO:0000256|RuleBase:RU000633,
ECO:0000256|SAAS:SAAS00895071, ECO:0000313|EMBL:ABU86738.1};
Membrane {ECO:0000256|SAAS:SAAS00895947, ECO:0000256|SAM:Phobius};
Proteomics identification {ECO:0000213|PeptideAtlas:A8DSD5};
Reference proteome {ECO:0000313|Proteomes:UP000008227};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00895947,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00895947,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 769 Integrin beta. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014566164.
TRANSMEM 701 726 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 24 74 PSI. {ECO:0000259|SMART:SM00423}.
DOMAIN 32 447 INB. {ECO:0000259|SMART:SM00187}.
DOMAIN 622 700 Integrin_B_tail.
{ECO:0000259|SMART:SM01242}.
DOMAIN 724 769 Integrin_b_cyt.
{ECO:0000259|SMART:SM01241}.
DISULFID 25 447 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 33 43 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 36 73 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 46 62 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 191 198 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 246 286 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 420 662 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 445 449 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 467 506 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 472 481 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 483 497 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 512 517 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 514 549 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 519 534 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 536 541 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 557 562 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 559 590 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 564 573 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 575 582 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 596 601 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 598 643 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 603 612 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 615 618 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 622 631 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 628 695 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 647 670 {ECO:0000256|PIRSR:PIRSR002512-1}.
SEQUENCE 769 AA; 84703 MW; 321A44CC41DDCC2E CRC64;
MLCRCSPLLL LVGLLTLRSA LSQECAKYKV STCRDCIESG PGCAWCQKLN FSGQGEPDSV
RCDTREQLLA KGCVADDIVD PRSLAETQED QAGGQKQLSP QKVTLYLRPG QAATFNVTFR
RAKGYPIDLY YLMDLSYSML DDLINVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV
NTHPEKLRNP CPNKEKECQA PFAFRHVLKL TDNSNQFQTE VGKQLISGNL DAPEGGLDAM
MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKSSNEFD
YPSVGQLAHK LAESNIQPIF AVTKKMVKTY EKLTDIIPKS AVGELSEDSS NVVQLIKNAY
NKLSSRVFLD HNALPDTLKV TYDSFCSNGV SQVNQPRGDC DGVQINVPIT FQVKVTASEC
IQEQSFVIRA LGFTDTVTVR VLPQCECRCG DSSKERSLCG NKGSMECGVC RCDAGYIGKH
CECQTQGRSS QELEGSCRKD NSSIICSGLG DCICGQCVCH TSDVPNKKIY GQFCECDNMN
CERFDGQVCG GEKRGLCFCG TCRCQEGFEG SACQCLKSTQ GCLNLQGVEC SGRGRCRCNV
CQCDFGYQPP LCTDCPSCQV PCARYAKCAE CLKFDTGPFA KNCSAECGTT KLLPSRMSGR
KCNERDSEGC WMTYFLVQRD GRDNYDLHVE ETRECVKGPN IAAIVGGTVG GVVLVGIFLL
AIWKVLTHLS DLREYKRFEK EKLKSQWNND NPLFKSATTT VMNPKFAER


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