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Integrin beta

 F6WLF2_CALJA            Unreviewed;      1087 AA.
F6WLF2;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
20-JUN-2018, sequence version 2.
18-JUL-2018, entry version 56.
RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
Name=ITGB1 {ECO:0000313|Ensembl:ENSCJAP00000025265};
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025265, ECO:0000313|Proteomes:UP000008225};
[1] {ECO:0000313|Ensembl:ENSCJAP00000025265, ECO:0000313|Proteomes:UP000008225}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSCJAP00000025265}
IDENTIFICATION.
Ensembl;
Submitted (JUN-2011) to UniProtKB.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000633};
Single-pass type I membrane protein
{ECO:0000256|RuleBase:RU000633}.
-!- SIMILARITY: Belongs to the integrin beta chain family.
{ECO:0000256|RuleBase:RU000633}.
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STRING; 9483.ENSCJAP00000025265; -.
Ensembl; ENSCJAT00000026698; ENSCJAP00000025265; ENSCJAG00000013701.
KEGG; cjc:100394145; -.
CTD; 3688; -.
eggNOG; KOG1226; Eukaryota.
eggNOG; ENOG410XP60; LUCA.
GeneTree; ENSGT00760000119064; -.
InParanoid; F6WLF2; -.
KO; K05719; -.
OMA; NVYTMSH; -.
OrthoDB; EOG091G029W; -.
TreeFam; TF105392; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0030175; C:filopodium; IEA:Ensembl.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0034665; C:integrin alpha1-beta1 complex; IEA:Ensembl.
GO; GO:0034680; C:integrin alpha10-beta1 complex; IEA:Ensembl.
GO; GO:0034681; C:integrin alpha11-beta1 complex; IEA:Ensembl.
GO; GO:0034666; C:integrin alpha2-beta1 complex; IEA:Ensembl.
GO; GO:0034667; C:integrin alpha3-beta1 complex; IEA:Ensembl.
GO; GO:0034677; C:integrin alpha7-beta1 complex; IEA:Ensembl.
GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
GO; GO:0071438; C:invadopodium membrane; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0035748; C:myelin sheath abaxonal region; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0032587; C:ruffle membrane; IEA:Ensembl.
GO; GO:0042383; C:sarcolemma; IEA:Ensembl.
GO; GO:0097060; C:synaptic membrane; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0019960; F:C-X3-C chemokine binding; IEA:Ensembl.
GO; GO:0098639; F:collagen binding involved in cell-matrix adhesion; IEA:Ensembl.
GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0043236; F:laminin binding; IEA:Ensembl.
GO; GO:0002020; F:protease binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
GO; GO:0007161; P:calcium-independent cell-matrix adhesion; IEA:Ensembl.
GO; GO:0055007; P:cardiac muscle cell differentiation; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0033631; P:cell-cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; IEA:Ensembl.
GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
GO; GO:0021943; P:formation of radial glial scaffolds; IEA:Ensembl.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:0050901; P:leukocyte tethering or rolling; IEA:Ensembl.
GO; GO:0048333; P:mesodermal cell differentiation; IEA:Ensembl.
GO; GO:2000811; P:negative regulation of anoikis; IEA:Ensembl.
GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0043547; P:positive regulation of GTPase activity; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:2000273; P:positive regulation of signaling receptor activity; IEA:Ensembl.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
GO; GO:0010710; P:regulation of collagen catabolic process; IEA:Ensembl.
GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
GO; GO:0008542; P:visual learning; IEA:Ensembl.
Gene3D; 3.40.50.410; -; 1.
InterPro; IPR013111; EGF_extracell.
InterPro; IPR027071; Integrin_beta-1.
InterPro; IPR033760; Integrin_beta_N.
InterPro; IPR015812; Integrin_bsu.
InterPro; IPR014836; Integrin_bsu_cyt_dom.
InterPro; IPR012896; Integrin_bsu_tail.
InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
InterPro; IPR002369; Integrin_bsu_VWA.
InterPro; IPR032695; Integrin_dom_sf.
InterPro; IPR016201; PSI.
InterPro; IPR036465; vWFA_dom_sf.
PANTHER; PTHR10082; PTHR10082; 1.
PANTHER; PTHR10082:SF28; PTHR10082:SF28; 1.
Pfam; PF07974; EGF_2; 1.
Pfam; PF08725; Integrin_b_cyt; 1.
Pfam; PF07965; Integrin_B_tail; 1.
Pfam; PF00362; Integrin_beta; 1.
Pfam; PF17205; PSI_integrin; 1.
PRINTS; PR01186; INTEGRINB.
SMART; SM00187; INB; 1.
SMART; SM01241; Integrin_b_cyt; 1.
SMART; SM01242; Integrin_B_tail; 1.
SMART; SM00423; PSI; 1.
SUPFAM; SSF53300; SSF53300; 1.
SUPFAM; SSF69179; SSF69179; 1.
SUPFAM; SSF69687; SSF69687; 1.
PROSITE; PS00243; INTEGRIN_BETA; 1.
3: Inferred from homology;
Cell adhesion {ECO:0000256|RuleBase:RU000633};
Complete proteome {ECO:0000313|Proteomes:UP000008225};
Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
Integrin {ECO:0000256|RuleBase:RU000633,
ECO:0000256|SAAS:SAAS00895071};
Membrane {ECO:0000256|SAAS:SAAS00895947, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000008225};
Transmembrane {ECO:0000256|SAAS:SAAS00895947,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00895947,
ECO:0000256|SAM:Phobius}.
TRANSMEM 1015 1037 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 312 362 PSI. {ECO:0000259|SMART:SM00423}.
DOMAIN 320 750 INB. {ECO:0000259|SMART:SM00187}.
DOMAIN 926 1014 Integrin_B_tail.
{ECO:0000259|SMART:SM01242}.
DOMAIN 1038 1084 Integrin_b_cyt.
{ECO:0000259|SMART:SM01241}.
DISULFID 321 331 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 324 361 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 334 350 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 493 499 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 547 587 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 721 977 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 748 752 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 763 775 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 772 811 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 777 786 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 788 802 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 817 822 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 819 854 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 824 839 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 841 846 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 860 865 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 862 893 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 867 876 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 878 885 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 899 904 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 901 947 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 906 916 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 919 922 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 926 935 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 932 1009 {ECO:0000256|PIRSR:PIRSR002512-1}.
DISULFID 951 985 {ECO:0000256|PIRSR:PIRSR002512-1}.
SEQUENCE 1087 AA; 119584 MW; 430CD0FA63DA0DBB CRC64;
MDFQINLSKA AHNSPFSKTF PIPTLRGTHG LPQVFTFFLD TRKHILTPGK QSWLSQFPSR
RTTLFLPPWS PAGSGAQVPI CLGTEGGASW VQDLTGSKRD ISGQTGREVG RAAPRKRNQK
TLAQEATPGT RGALGRTRPL TPFTEEETEA RDGLCGVSAP PSTVYPKARS RAGRFLCPGS
ASCLLLAPGP ADAAGEECVS GGSGRRLRPR ERDRTRREGG AAASFLPGGG SGPPSPLLPP
LRGRSRRRPP RPRPGRPRQP AREAEREPRS SRPEPTAPGL GRRAEKMNLQ LIFWIGLISS
VCCVFGQTDE NRCLKANAKS CGECIQAGPN CGWCTNSTFL QEGMPTSARC DDLEALKKKG
CPPDDIENPR GSKDIKKNKN VTNRSKGTAE KLKPEDITQI QPQQLVLRLR SGEPQTFTLK
FKRAEDYPID LYYLMDLSYS MKDDLENVKS LGTDLMNEMR RITSDFRIGF GSFVEKTVMP
YISTTPAKLR NPCTSEQNCT SPFSYKNVLS LTNKGEVFNE LVGKQRISGN LDSPEGGFDA
IMQVAVCGSL IGWRNVTRLL VFSTDAGFHF AGDGKLGGIV LPNDGQCHLE NNMYTMSHYY
DYPSIAHLVQ KLSENNIQTI FAVTEEFQPV YKELKNLIPK SAVGTLSSNS SNVIQLIIDA
YNSLSSEVIL ENSKLSEGVT ISYKSYCKNG VNGTGENGRK CSNISIGDEV QFEISITSNK
CPKKDSDAFK IRPLGFTEEV EVILQYICEC ECQSEGIPGS PKCHEGNGTF ECGACRCNEG
RVGRHCECST DEVNSEDMDA YCRKENSSEI CSNNGECICG QCVCRKRDNT NEIYSGKFCE
CDNFNCDRSN GLICGGNGVC KCRVCECYPN YTGSACDCSL DTSTCVASNG QICNGRGICE
CGVCKCTDPK FQGQTCEMCQ TCLGVCAEHK ECVQCRAFNK GEKKDTCAQE CSYFNITKVE
SREKLPQPVQ PDPVSHCKEK DVDDCWFYFT YSVNGNNEIM VHVVENPECP TGPDIIPIVA
GVVAGIVLIG LALLLIWKLL MIIHDRREFA KFEKEKMNAK WDTQENPIYK SPINNFKNPN
YGRKAGL


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