Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Intercellular adhesion molecule 1 (ICAM-1) (CD antigen CD54)

 ICAM1_GORGO             Reviewed;         532 AA.
Q5NKV9;
15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 1.
25-OCT-2017, entry version 85.
RecName: Full=Intercellular adhesion molecule 1;
Short=ICAM-1;
AltName: CD_antigen=CD54;
Flags: Precursor;
Name=ICAM1;
Gorilla gorilla gorilla (Western lowland gorilla).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Gorilla.
NCBI_TaxID=9595;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Isolate Kudzu, and Isolate Rok; TISSUE=Blood;
Messier W., Walter N.A.R., Hink R.L.;
"The chimpanzee ICAM proteins have been positively selected.";
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: ICAM proteins are ligands for the leukocyte adhesion
protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-
endothelial migration, ICAM1 engagement promotes the assembly of
endothelial apical cups through ARHGEF26/SGEF and RHOG activation
(By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with MUC1 and promotes cell
aggregation in epithelial cells. Interacts with ARHGEF26/SGEF (By
similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
membrane protein {ECO:0000250}.
-!- PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to
endocytosis. {ECO:0000250}.
-!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM
family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF340036; AAQ14899.1; -; mRNA.
EMBL; AF340037; AAQ14900.1; -; mRNA.
RefSeq; NP_001266532.1; NM_001279603.1.
ProteinModelPortal; Q5NKV9; -.
SMR; Q5NKV9; -.
STRING; 9593.ENSGGOP00000005852; -.
Ensembl; ENSGGOT00000006009; ENSGGOP00000005852; ENSGGOG00000005980.
GeneID; 101127502; -.
CTD; 3383; -.
GeneTree; ENSGT00530000063246; -.
HOVERGEN; HBG052074; -.
InParanoid; Q5NKV9; -.
OMA; QTLRCQA; -.
OrthoDB; EOG091G022Y; -.
Proteomes; UP000001519; Chromosome 19.
Bgee; ENSGGOG00000005980; -.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0031012; C:extracellular matrix; IEA:Ensembl.
GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0033627; P:cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
GO; GO:0061028; P:establishment of endothelial barrier; IEA:Ensembl.
GO; GO:0007159; P:leukocyte cell-cell adhesion; IEA:Ensembl.
GO; GO:0050900; P:leukocyte migration; IEA:Ensembl.
GO; GO:0022614; P:membrane to membrane docking; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0002693; P:positive regulation of cellular extravasation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0046813; P:receptor-mediated virion attachment to host cell; IEA:Ensembl.
GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
GO; GO:1900027; P:regulation of ruffle assembly; IEA:Ensembl.
GO; GO:0002291; P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; IEA:Ensembl.
GO; GO:0002457; P:T cell antigen processing and presentation; IEA:Ensembl.
Gene3D; 2.60.40.10; -; 7.
InterPro; IPR003988; ICAM.
InterPro; IPR013768; ICAM_N.
InterPro; IPR003987; ICAM_VCAM_N.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
Pfam; PF03921; ICAM_N; 1.
PRINTS; PR01473; ICAM.
PRINTS; PR01472; ICAMVCAM1.
SMART; SM00409; IG; 3.
SUPFAM; SSF48726; SSF48726; 5.
2: Evidence at transcript level;
Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome;
Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1 27 {ECO:0000250}.
CHAIN 28 532 Intercellular adhesion molecule 1.
/FTId=PRO_0000014782.
TOPO_DOM 28 480 Extracellular. {ECO:0000255}.
TRANSMEM 481 503 Helical. {ECO:0000255}.
TOPO_DOM 504 532 Cytoplasmic. {ECO:0000255}.
DOMAIN 41 103 Ig-like C2-type 1.
DOMAIN 128 193 Ig-like C2-type 2.
DOMAIN 230 297 Ig-like C2-type 3.
DOMAIN 325 378 Ig-like C2-type 4.
DOMAIN 412 464 Ig-like C2-type 5.
MOTIF 152 154 Cell attachment site; atypical.
{ECO:0000255}.
MOD_RES 521 521 Phosphothreonine.
{ECO:0000250|UniProtKB:P05362}.
MOD_RES 530 530 Phosphothreonine.
{ECO:0000250|UniProtKB:P05362}.
CARBOHYD 202 202 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 267 267 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 385 385 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 406 406 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 48 92 {ECO:0000250|UniProtKB:P05362}.
DISULFID 52 96 {ECO:0000250|UniProtKB:P05362}.
DISULFID 135 186 {ECO:0000250|UniProtKB:P05362}.
DISULFID 237 290 {ECO:0000250|UniProtKB:P05362}.
DISULFID 332 371 {ECO:0000250|UniProtKB:P05362}.
DISULFID 403 419 {ECO:0000250|UniProtKB:P05362}.
DISULFID 419 457 {ECO:0000250}.
DISULFID 431 457 {ECO:0000250|UniProtKB:P05362}.
SEQUENCE 532 AA; 57848 MW; 53D400591CCE0B52 CRC64;
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPPKVILPR GGSVLVTCST SCDQPTLLGI
ETPLPKKELL LLGNNQKVYE LSNVQEDSQP MCYSNCPDGQ STAKTFLTVY WTPERVELAP
LPSWQPVGKD LTLRCQVEGG APRANLIVVL LRGEEELKRE PAVGEPAEVT TTVPVEKDHH
GANFLCRTEL DLRPQGLKLF ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD
GLFPVSEAQV HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQWLTC AVILGTQSQE
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPP GPRTQFLLKA
TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE RDCPGNWTWP ENSQQTPMCQ
AWGNPLPELK CLKDGTFPLP VGESVTVTRD LEGTYLCRAR STQGEVTREV TVNVLSPRYE
FVIIAVVAAA VIMGTAGLST YLYNRQRKIR KYRLQQAQKG TPMKPNTQAT PP


Related products :

Catalog number Product name Quantity
10-663-45658 Intercellular Adhesion Molecule-1 (ICAM-1) Human - ICAM-1; Major group rhinovirus receptor; CD54 antigen N_A 0.002 mg
10-663-45658 Intercellular Adhesion Molecule-1 (ICAM-1) Human - ICAM-1; Major group rhinovirus receptor; CD54 antigen N_A 0.01 mg
10-663-45658 Intercellular Adhesion Molecule-1 (ICAM-1) Human - ICAM-1; Major group rhinovirus receptor; CD54 antigen N_A 1 mg
CSB-E08898c Dog intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
228-10812-2 Recombinant Human Intercellular Adhesion Molecule-1 (ICAM-1) _ CD54 10
228-10812-1 Recombinant Human Intercellular Adhesion Molecule-1 (ICAM-1) _ CD54 2
CSB-E06974Rb rabbit intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
KN0117Rb Rabbit intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96 WELLS
UB-E70049 Canine intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
SL0103Rb Rabbit intercellular adhesion molecule 1,ICAM-1 CD54 ELISA Kit 96T
UB-C80012 Chicken Intercellular Adhesion Molecule 1,ICAM-1 CD54 ELISA Kit 96T
UB-E80012 Chicken intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
UB-E70147 Canine intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
UB-E30194 rabbit intercellular adhesion molecule 1,ICAM-1 per CD54 ELISA Kit 96T
MD-11-0091 Mouse Anti-Human Intercellular Adhesion Molecule-1 (ICAM-1) _ CD54 200
20-321-175250 CD54. INTRACELLULAR ADHESION MOLECULE-1 (ICAM-1) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN CD54. INTRACELLULAR ADHESION MOLECULE-1 (ICAM-1) Monoclonal 0.05 mg
20-321-175249 CD54. INTRACELLULAR ADHESION MOLECULE-1 (ICAM-1) - MONOCLONAL ANTIBODY TO HUMAN CD54. INTRACELLULAR ADHESION MOLECULE-1 (ICAM-1) Monoclonal 0.1 mg
U0048r CLIA Icam1,ICAM-1,Icam-1,Intercellular adhesion molecule 1,Rat,Rattus norvegicus 96T
E0048r ELISA Icam1,ICAM-1,Icam-1,Intercellular adhesion molecule 1,Rat,Rattus norvegicus 96T
E0048r ELISA kit Icam1,ICAM-1,Icam-1,Intercellular adhesion molecule 1,Rat,Rattus norvegicus 96T
E0533h ELISA kit CDw50,Homo sapiens,Human,ICAM3,ICAM-3,ICAM-R,Intercellular adhesion molecule 3 96T
E0533h ELISA CDw50,Homo sapiens,Human,ICAM3,ICAM-3,ICAM-R,Intercellular adhesion molecule 3 96T
E0048m ELISA kit Icam1,ICAM-1,Icam-1,Intercellular adhesion molecule 1,MALA-2,Mouse,Mus musculus,MyD10 96T
E0048m ELISA Icam1,ICAM-1,Icam-1,Intercellular adhesion molecule 1,MALA-2,Mouse,Mus musculus,MyD10 96T
U0533h CLIA CDw50,Homo sapiens,Human,ICAM3,ICAM-3,ICAM-R,Intercellular adhesion molecule 3 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur