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Interferon gamma (IFN-gamma)

 A8DBM8_MUSPF            Unreviewed;       166 AA.
A8DBM8;
13-NOV-2007, integrated into UniProtKB/TrEMBL.
13-NOV-2007, sequence version 1.
25-OCT-2017, entry version 50.
RecName: Full=Interferon gamma {ECO:0000256|PIRNR:PIRNR001936};
Short=IFN-gamma {ECO:0000256|PIRNR:PIRNR001936};
Name=IFN-g {ECO:0000313|EMBL:ABS50096.1};
Synonyms=IFNG {ECO:0000313|Ensembl:ENSMPUP00000017401};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
Mustelinae; Mustela.
NCBI_TaxID=9669 {ECO:0000313|EMBL:ABS50096.1};
[1] {ECO:0000313|EMBL:ABS50096.1}
NUCLEOTIDE SEQUENCE.
Ochi A., Danesh A., Seneviratne C., Banner D., DeVries M.E., Rowe T.,
Xu L., Ran L., Bosinger S.E., Jonsson C.B., Cameron C.M., Kelvin D.J.;
"Cloning, Expression and Immunoassay Detection of Ferret IFN-g.";
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000017401}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000017401};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
Walker B.J., Young S., Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSMPUP00000017401}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR001936}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001936}.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000256|PIRNR:PIRNR001936}.
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EMBL; AEYP01031567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF492064; ABS50096.1; -; mRNA.
Ensembl; ENSMPUT00000017658; ENSMPUP00000017401; ENSMPUG00000017512.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
GeneTree; ENSGT00390000007831; -.
HOVERGEN; HBG056912; -.
OMA; WKEESDK; -.
OrthoDB; EOG091G0ZH0; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0071351; P:cellular response to interleukin-18; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IEA:Ensembl.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0031642; P:negative regulation of myelination; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0001781; P:neutrophil apoptotic process; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:1903543; P:positive regulation of exosomal secretion; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0050691; P:regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
ProDom; PD002435; Interferon_gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense {ECO:0000256|PIRNR:PIRNR001936};
Complete proteome {ECO:0000313|Proteomes:UP000000715};
Cytokine {ECO:0000256|PIRNR:PIRNR001936};
Growth regulation {ECO:0000256|PIRNR:PIRNR001936};
Reference proteome {ECO:0000313|Proteomes:UP000000715};
Secreted {ECO:0000256|PIRNR:PIRNR001936}.
SEQUENCE 166 AA; 19613 MW; 1E19CDB77629418E CRC64;
MNYTNYILAF QLCVIFCSSG YYCQAMFFKE IEDLKEYFNA SNPDVADGGP LFLDILKNWR
EESDKKIIQS QIVSFYLKLF ENFKDNQIIQ RSMDTIKEDM LVRFFNNSSS KLEDFLKLIR
IPVNDLQVQR KAINELIKVM NDLSPRSNLR KRKRSHSVFP GRRASK


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