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Interferon gamma (IFN-gamma)

 IFNG_EQUAS              Reviewed;         166 AA.
O77763;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
25-OCT-2017, entry version 75.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Equus asinus (Donkey) (Equus africanus asinus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9793;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Burr P.D., Nasir L., Nicolson L., Argyle D.J., Reid S.W.J.;
"Nucleotide sequence of the donkey interferon gamma cDNA.";
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Released primarily from activated T
lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; AF055341; AAC42595.1; -; mRNA.
RefSeq; XP_014716180.1; XM_014860694.1.
ProteinModelPortal; O77763; -.
SMR; O77763; -.
GeneID; 106843591; -.
KEGG; eai:106843591; -.
CTD; 3458; -.
HOVERGEN; HBG056912; -.
KO; K04687; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
ProDom; PD002435; Interferon_gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Glycoprotein; Growth regulation;
Pyrrolidone carboxylic acid; Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 166 Interferon gamma.
/FTId=PRO_0000016441.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01579}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 106 106 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 166 AA; 19311 MW; A335B4E05B7132AD CRC64;
MNYTSFILAF QLCAILGSST YYCQAAFFKE IENLKEYFNA SSPDVGDGGP LFLDILKNWK
EDSDKKIIQS QIVSFYFKLF ENLKDNQVIQ KSMDTIKEDL FVKFFNSSTS KLEDFQKLIQ
IPVNDLKVQR KAISELIKVM NDLSPKANLR KRKRSQNPFR GRRALQ


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