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Interferon gamma (IFN-gamma)

 IFNG_FELCA              Reviewed;         167 AA.
P46402;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
25-OCT-2017, entry version 113.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
PubMed=7612928; DOI=10.3109/10425179509029357;
Argyle D.J., Smith K., McBride K., Fulton R., Onions D.E.;
"Nucleotide and predicted peptide sequence of feline interferon-gamma
(IFN-gamma).";
DNA Seq. 5:169-171(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7590986; DOI=10.1007/BF00179414;
Schijns V.E.C.J., Wierda C.M.H., Vahlenkamp T.W., Horzinek M.C.,
de Groot R.J.;
"Molecular cloning and expression of cat interferon-gamma.";
Immunogenetics 42:440-441(1995).
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Released primarily from activated T
lymphocytes.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D30619; BAA06309.1; -; mRNA.
EMBL; X86972; CAA60535.1; -; Genomic_DNA.
PIR; S57644; S57644.
RefSeq; NP_001009873.1; NM_001009873.1.
ProteinModelPortal; P46402; -.
SMR; P46402; -.
STRING; 9685.ENSFCAP00000008355; -.
Ensembl; ENSFCAT00000009016; ENSFCAP00000008355; ENSFCAG00000009014.
GeneID; 493965; -.
KEGG; fca:493965; -.
CTD; 3458; -.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
GeneTree; ENSGT00390000007831; -.
HOGENOM; HOG000254784; -.
HOVERGEN; HBG056912; -.
InParanoid; P46402; -.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; EOG091G0ZH0; -.
TreeFam; TF336308; -.
Proteomes; UP000011712; Chromosome B4.
Bgee; ENSFCAG00000009014; -.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0071351; P:cellular response to interleukin-18; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:Ensembl.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0031642; P:negative regulation of myelination; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0001781; P:neutrophil apoptotic process; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:1903543; P:positive regulation of exosomal secretion; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0050691; P:regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
ProDom; PD002435; Interferon_gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Complete proteome; Cytokine; Glycoprotein;
Growth regulation; Pyrrolidone carboxylic acid; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 167 Interferon gamma.
/FTId=PRO_0000016442.
MOD_RES 24 24 Pyrrolidone carboxylic acid.
{ECO:0000250|UniProtKB:P01579}.
CARBOHYD 39 39 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 107 107 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 167 AA; 19623 MW; CF60183F0609DD12 CRC64;
MNYTSFIFAF QLCIILCSSG YYCQAMFFKE IEELKGYFNA SNPDVADGGS LFVDILKNWK
EESDKTIIQS QIVSFYLKMF ENLKDDDQRI QRSMDTIKED MLDKLLNTSS SKRDDFLKLI
QIPVNDLQVQ RKAINELFKV MNDLSPRSNL RKRKRSQNLF RGRRASK


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