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Interferon gamma (IFN-gamma)

 IFNG_CHICK              Reviewed;         164 AA.
P49708; D3GGX1; Q53YS2;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
05-DEC-2018, entry version 126.
RecName: Full=Interferon gamma;
Short=IFN-gamma;
Flags: Precursor;
Name=IFNG;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8590305; DOI=10.1089/jir.1995.15.939;
Digby M.R., Lowenthal J.W.;
"Cloning and expression of the chicken interferon-gamma gene.";
J. Interferon Cytokine Res. 15:939-945(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8898958; DOI=10.1002/eji.1830261026;
Weining K.C., Schultz U., Muenster U., Kaspers B., Staeheli P.;
"Biological properties of recombinant chicken interferon-gamma.";
Eur. J. Immunol. 26:2440-2447(1996).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=N LINE;
PubMed=9511740; DOI=10.1016/S0378-1119(97)00600-8;
Kaiser P., Wain H.M., Rothwell L.;
"Structure of the chicken interferon-gamma gene, and comparison to
mammalian homologues.";
Gene 207:25-32(1998).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=White leghorn; TISSUE=Spleen;
Song K.D., Kim D.K., Choi K.D., Lillehoj H.S., Han I.K., Han J.Y.;
"Molecular genetic analysis of chicken interferon gamma gene.";
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Spleen;
Lv Y.Z., Cao Y.C., Bi Y.Z.;
"Chicken interferon-gamma.";
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Spleen;
Bao M., Zhong D., Xu F., Yu W.;
"Cloning and expression of the chicken interferon-gamma gene.";
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Peripheral blood lymphocyte;
Zhang X., Zhang C., Li Y., Cheng X., Wu T.;
"Cloning and sequence analysis of interferon gamma of China Lushi
chicken.";
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Produced by lymphocytes activated by specific antigens
or mitogens. IFN-gamma, in addition to having antiviral activity,
has important immunoregulatory functions. It is a potent activator
of macrophages, it has antiproliferative effects on transformed
cells and it can potentiate the antiviral and antitumor effects of
the type I interferons (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the type II (or gamma) interferon family.
{ECO:0000305}.
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EMBL; U27465; AAC59723.1; -; mRNA.
EMBL; X99774; CAA68118.1; -; mRNA.
EMBL; Y07922; CAA69227.1; -; Genomic_DNA.
EMBL; U96875; AAG27918.1; -; Genomic_DNA.
EMBL; U96872; AAG27918.1; JOINED; Genomic_DNA.
EMBL; U96873; AAG27918.1; JOINED; Genomic_DNA.
EMBL; U96874; AAG27918.1; JOINED; Genomic_DNA.
EMBL; AF424744; AAL17845.1; -; mRNA.
EMBL; AY501004; AAR98863.1; -; mRNA.
EMBL; FJ788637; ACY72343.1; -; mRNA.
PIR; JC6536; JC6536.
RefSeq; NP_990480.1; NM_205149.1.
UniGene; Gga.916; -.
ProteinModelPortal; P49708; -.
SMR; P49708; -.
STRING; 9031.ENSGALP00000016086; -.
PaxDb; P49708; -.
Ensembl; ENSGALT00000016105; ENSGALP00000016086; ENSGALG00000009903.
GeneID; 396054; -.
KEGG; gga:396054; -.
CTD; 3458; -.
eggNOG; ENOG410IWSY; Eukaryota.
eggNOG; ENOG410Z8I5; LUCA.
GeneTree; ENSGT00390000007831; -.
HOGENOM; HOG000254784; -.
HOVERGEN; HBG056912; -.
InParanoid; P49708; -.
KO; K04687; -.
OMA; WKEESDK; -.
OrthoDB; EOG091G0ZH0; -.
PhylomeDB; P49708; -.
TreeFam; TF336308; -.
Reactome; R-GGA-877300; Interferon gamma signaling.
Reactome; R-GGA-877312; Regulation of IFNG signaling.
PRO; PR:P49708; -.
Proteomes; UP000000539; Chromosome 1.
Bgee; ENSGALG00000009903; Expressed in 3 organ(s), highest expression level in spleen.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005133; F:interferon-gamma receptor binding; IEA:InterPro.
GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IDA:AgBase.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
GO; GO:0060333; P:interferon-gamma-mediated signaling pathway; IEA:Ensembl.
GO; GO:0042116; P:macrophage activation; IDA:AgBase.
GO; GO:0045918; P:negative regulation of cytolysis; IDA:AgBase.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
GO; GO:0060559; P:positive regulation of calcidiol 1-monooxygenase activity; IEA:Ensembl.
GO; GO:0032834; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response; IEA:Ensembl.
GO; GO:1904798; P:positive regulation of core promoter binding; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0060550; P:positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity; IEA:Ensembl.
GO; GO:0060552; P:positive regulation of fructose 1,6-bisphosphate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032747; P:positive regulation of interleukin-23 production; IEA:Ensembl.
GO; GO:0051712; P:positive regulation of killing of cells of other organism; IEA:Ensembl.
GO; GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0031334; P:positive regulation of protein complex assembly; IEA:Ensembl.
GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
GO; GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IDA:AgBase.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:2000309; P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; TAS:AgBase.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0050796; P:regulation of insulin secretion; IEA:Ensembl.
GO; GO:0010835; P:regulation of protein ADP-ribosylation; IEA:Ensembl.
GO; GO:0070673; P:response to interleukin-18; IDA:AgBase.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002069; Interferon_gamma.
PANTHER; PTHR11419; PTHR11419; 1.
Pfam; PF00714; IFN-gamma; 1.
PIRSF; PIRSF001936; IFN-gamma; 1.
ProDom; PD002435; Interferon_gamma; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Antiviral defense; Complete proteome; Cytokine; Glycoprotein;
Growth regulation; Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 164 Interferon gamma.
/FTId=PRO_0000016463.
CARBOHYD 42 42 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 61 61 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 164 AA; 18953 MW; 18D9B0BCA415B600 CRC64;
MTCQTYNLFV LSVIMIYYGH TASSLNLVQL QDDIDKLKAD FNSSHSDVAD GGPIIVEKLK
NWTERNEKRI ILSQIVSMYL EMLENTDKSK PHIKHISEEL YTLKNNLPDG VKKVKDIMDL
AKLPMNDLRI QRKAANELFS ILQKLVDPPS FKRKRSQSQR RCNC


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