Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Interferon lambda-3 (IFN-lambda-3) (Cytokine Zcyto22) (Interleukin-28B) (IL-28B) (Interleukin-28C) (IL-28C)

 IFNL3_HUMAN             Reviewed;         196 AA.
Q8IZI9; A2BDE1; Q6VN56; Q7Z4J3; Q8IWL6;
23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
13-JUL-2010, sequence version 2.
27-SEP-2017, entry version 110.
RecName: Full=Interferon lambda-3;
Short=IFN-lambda-3;
AltName: Full=Cytokine Zcyto22;
AltName: Full=Interleukin-28B;
Short=IL-28B;
AltName: Full=Interleukin-28C;
Short=IL-28C;
Flags: Precursor;
Name=IFNL3; Synonyms=IL28B, IL28C, ZCYTO22;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
PubMed=12469119; DOI=10.1038/ni873;
Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S.,
Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J.,
Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B.,
Cooper E., Taft D., Gilbert T., Grant F.J., Tackett M., Krivan W.,
McKnight G., Clegg C., Foster D., Klucher K.M.;
"IL-28, IL-29 and their class II cytokine receptor IL-28R.";
Nat. Immunol. 4:63-68(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
INDUCTION.
PubMed=12483210; DOI=10.1038/ni875;
Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M.,
Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.;
"IFN-lambdas mediate antiviral protection through a distinct class II
cytokine receptor complex.";
Nat. Immunol. 4:69-77(2003).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ARG-70.
TISSUE=Peripheral blood leukocyte;
PubMed=16539846; DOI=10.1111/j.1745-7254.2006.00292.x;
Li M.C., Wang H.Y., Wang H.Y., Li T., He S.H.;
"Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-
viral effect of IL-28 and IL-29 on WISH cells.";
Acta Pharmacol. Sin. 27:453-459(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
REVIEW.
PubMed=20712453; DOI=10.1089/jir.2010.0078;
Donnelly R.P., Kotenko S.V.;
"Interferon-lambda: a new addition to an old family.";
J. Interferon Cytokine Res. 30:555-564(2010).
[7]
REVIEW.
PubMed=24751921; DOI=10.1159/000360084;
Hermant P., Michiels T.;
"Interferon-lambda in the context of viral infections: production,
response and therapeutic implications.";
J. Innate Immun. 6:563-574(2014).
[8]
X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), DISULFIDE BONDS, AND
MUTAGENESIS OF LYS-57; ASP-58; VAL-118; GLN-121; PHE-176 AND PHE-179.
PubMed=19457860; DOI=10.1074/jbc.M109.002923;
Gad H.H., Dellgren C., Hamming O.J., Vends S., Paludan S.R.,
Hartmann R.;
"Interferon-lambda is functionally an interferon but structurally
related to the interleukin-10 family.";
J. Biol. Chem. 284:20869-20875(2009).
-!- FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory
activities. Plays a critical role in the antiviral host defense,
predominantly in the epithelial tissues. Acts as a ligand for the
heterodimeric class II cytokine receptor composed of IL10RB and
IFNLR1, and receptor engagement leads to the activation of the
JAK/STAT signaling pathway resulting in the expression of IFN-
stimulated genes (ISG), which mediate the antiviral state. Has a
restricted receptor distribution and therefore restricted targets:
is primarily active in epithelial cells and this cell type-
selective action is because of the epithelial cell-specific
expression of its receptor IFNLR1. Seems not to be essential for
early virus-activated host defense in vaginal infection, but plays
an important role in Toll-like receptor (TLR)-induced antiviral
defense. Plays a significant role in the antiviral immune defense
in the intestinal epithelium. Exerts an immunomodulatory effect by
up-regulating MHC class I antigen expression.
{ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
-!- INDUCTION: By viral infections or double-stranded RNA.
{ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
-!- SIMILARITY: Belongs to the lambda interferon family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAN28264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AY129149; AAN28264.1; ALT_INIT; mRNA.
EMBL; AY184374; AAN86127.1; -; mRNA.
EMBL; AY336714; AAR24509.1; -; mRNA.
EMBL; AY336717; AAQ01561.1; -; mRNA.
EMBL; AC011445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC130314; AAI30315.1; -; mRNA.
EMBL; BC130316; AAI30317.1; -; mRNA.
CCDS; CCDS12530.1; -.
RefSeq; NP_001333866.1; NM_001346937.1.
RefSeq; NP_742151.2; NM_172139.3.
UniGene; Hs.406744; -.
PDB; 3HHC; X-ray; 2.80 A; A/B/C/D=1-196.
PDB; 5T5W; X-ray; 2.85 A; C=34-195.
PDBsum; 3HHC; -.
PDBsum; 5T5W; -.
ProteinModelPortal; Q8IZI9; -.
SMR; Q8IZI9; -.
BioGrid; 129395; 2.
IntAct; Q8IZI9; 1.
STRING; 9606.ENSP00000409000; -.
iPTMnet; Q8IZI9; -.
PhosphoSitePlus; Q8IZI9; -.
BioMuta; IFNL3; -.
DMDM; 300669648; -.
PaxDb; Q8IZI9; -.
PeptideAtlas; Q8IZI9; -.
PRIDE; Q8IZI9; -.
DNASU; 282617; -.
Ensembl; ENST00000413851; ENSP00000409000; ENSG00000197110.
GeneID; 282617; -.
KEGG; hsa:282617; -.
UCSC; uc010xut.3; human.
CTD; 282617; -.
DisGeNET; 282617; -.
EuPathDB; HostDB:ENSG00000197110.8; -.
GeneCards; IFNL3; -.
HGNC; HGNC:18365; IFNL3.
MalaCards; IFNL3; -.
MIM; 607402; gene.
neXtProt; NX_Q8IZI9; -.
OpenTargets; ENSG00000197110; -.
Orphanet; 284102; Response to antiviral treatment in hepatitis C.
PharmGKB; PA134952671; -.
eggNOG; ENOG410J0IH; Eukaryota.
eggNOG; ENOG410ZDRD; LUCA.
GeneTree; ENSGT00390000014310; -.
HOGENOM; HOG000232074; -.
HOVERGEN; HBG052108; -.
InParanoid; Q8IZI9; -.
KO; K05447; -.
PhylomeDB; Q8IZI9; -.
TreeFam; TF336172; -.
SignaLink; Q8IZI9; -.
SIGNOR; Q8IZI9; -.
EvolutionaryTrace; Q8IZI9; -.
GeneWiki; Interleukin_28B; -.
GenomeRNAi; 282617; -.
PRO; PR:Q8IZI9; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000197110; -.
CleanEx; HS_IL28B; -.
ExpressionAtlas; Q8IZI9; baseline and differential.
Genevisible; Q8IZI9; HS.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005102; F:receptor binding; IBA:GO_Central.
GO; GO:0051607; P:defense response to virus; ISS:UniProtKB.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0007259; P:JAK-STAT cascade; IEA:InterPro.
GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
GO; GO:0050778; P:positive regulation of immune response; IEA:InterPro.
GO; GO:1903955; P:positive regulation of protein targeting to mitochondrion; IMP:ParkinsonsUK-UCL.
GO; GO:0050863; P:regulation of T cell activation; IBA:GO_Central.
InterPro; IPR029177; INF_lambda.
Pfam; PF15177; IL28A; 1.
1: Evidence at protein level;
3D-structure; Antiviral defense; Complete proteome; Cytokine;
Disulfide bond; Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 196 Interferon lambda-3.
/FTId=PRO_0000015510.
DISULFID 37 136 {ECO:0000269|PubMed:19457860}.
DISULFID 71 169 {ECO:0000269|PubMed:19457860}.
DISULFID 188 195 {ECO:0000269|PubMed:19457860}.
VARIANT 28 28 R -> H (in dbSNP:rs629976).
/FTId=VAR_063419.
VARIANT 70 70 K -> R (in dbSNP:rs8103142).
{ECO:0000269|PubMed:16539846}.
/FTId=VAR_063420.
MUTAGEN 57 57 K->A: 51 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
MUTAGEN 58 58 D->A: 43 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
MUTAGEN 118 118 V->A: 68 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
MUTAGEN 121 121 Q->A: 46 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
MUTAGEN 176 176 F->A: 40 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
MUTAGEN 179 179 F->A: 650 fold decrease in antiviral
activity. {ECO:0000269|PubMed:19457860}.
CONFLICT 108 108 T -> S (in Ref. 2; AAN86127).
{ECO:0000305}.
CONFLICT 120 120 D -> G (in Ref. 3; AAQ01561).
{ECO:0000305}.
CONFLICT 155 155 L -> P (in Ref. 3; AAQ01561).
{ECO:0000305}.
CONFLICT 156 156 H -> Y (in Ref. 2; AAN86127).
{ECO:0000305}.
HELIX 40 42 {ECO:0000244|PDB:3HHC}.
HELIX 47 65 {ECO:0000244|PDB:3HHC}.
STRAND 71 73 {ECO:0000244|PDB:3HHC}.
HELIX 82 84 {ECO:0000244|PDB:3HHC}.
HELIX 87 89 {ECO:0000244|PDB:3HHC}.
HELIX 90 111 {ECO:0000244|PDB:3HHC}.
HELIX 113 134 {ECO:0000244|PDB:3HHC}.
HELIX 150 159 {ECO:0000244|PDB:3HHC}.
HELIX 161 163 {ECO:0000244|PDB:3HHC}.
HELIX 167 176 {ECO:0000244|PDB:3HHC}.
HELIX 178 182 {ECO:0000244|PDB:3HHC}.
HELIX 184 190 {ECO:0000244|PDB:3HHC}.
HELIX 191 194 {ECO:0000244|PDB:3HHC}.
SEQUENCE 196 AA; 21706 MW; F2322E10C887184B CRC64;
MTGDCMPVLV LMAAVLTVTG AVPVARLRGA LPDARGCHIA QFKSLSPQEL QAFKRAKDAL
EESLLLKDCK CRSRLFPRTW DLRQLQVRER PVALEAELAL TLKVLEATAD TDPALGDVLD
QPLHTLHHIL SQLRACIQPQ PTAGPRTRGR LHHWLHRLQE APKKESPGCL EASVTFNLFR
LLTRDLNCVA SGDLCV


Related products :

Catalog number Product name Quantity
E2028h ELISA Cytokine Zcyto22,Homo sapiens,Human,IFNL3,IFNL4,IFN-lambda-3,IFN-lambda-4,IL28B,IL-28B,IL28C,IL-28C,Interferon lambda-3,Interferon lambda-4,Interleukin-28B,Interleukin-28C,ZCYTO22 96T
E2028h ELISA kit Cytokine Zcyto22,Homo sapiens,Human,IFNL3,IFNL4,IFN-lambda-3,IFN-lambda-4,IL28B,IL-28B,IL28C,IL-28C,Interferon lambda-3,Interferon lambda-4,Interleukin-28B,Interleukin-28C,ZCYTO22 96T
U2028h CLIA kit Cytokine Zcyto22,Homo sapiens,Human,IFNL3,IFNL4,IFN-lambda-3,IFN-lambda-4,IL28B,IL-28B,IL28C,IL-28C,Interferon lambda-3,Interferon lambda-4,Interleukin-28B,Interleukin-28C,ZCYTO22 96T
U2028h CLIA Cytokine Zcyto22,Homo sapiens,Human,IFNL3,IFNL4,IFN-lambda-3,IFN-lambda-4,IL28B,IL-28B,IL28C,IL-28C,Interferon lambda-3,Interferon lambda-4,Interleukin-28B,Interleukin-28C,ZCYTO22 96T
U2029h CLIA Cytokine Zcyto21,Homo sapiens,Human,IFNL1,IFN-lambda-1,IL29,IL-29,Interferon lambda-1,Interleukin-29,ZCYTO21 96T
E2029h ELISA Cytokine Zcyto21,Homo sapiens,Human,IFNL1,IFN-lambda-1,IL29,IL-29,Interferon lambda-1,Interleukin-29,ZCYTO21 96T
U2029h CLIA kit Cytokine Zcyto21,Homo sapiens,Human,IFNL1,IFN-lambda-1,IL29,IL-29,Interferon lambda-1,Interleukin-29,ZCYTO21 96T
E1689h ELISA Cytokine Zcyto20,Homo sapiens,Human,IFNL2,IFN-lambda-2,IL28A,IL-28A,Interferon lambda-2,Interleukin-28A,ZCYTO20 96T
E1689h ELISA kit Cytokine Zcyto20,Homo sapiens,Human,IFNL2,IFN-lambda-2,IL28A,IL-28A,Interferon lambda-2,Interleukin-28A,ZCYTO20 96T
U1689h CLIA Cytokine Zcyto20,Homo sapiens,Human,IFNL2,IFN-lambda-2,IL28A,IL-28A,Interferon lambda-2,Interleukin-28A,ZCYTO20 96T
E2029h ELISA kit Cytokine Zcyto21,Homo sapiens,Human,IFNL1,IFN-lambda-1,IL29,IL-29,Interferon lambda-1,Interleukin-29,ZCYTO21 96T
E1689m ELISA Ifnl2,IFN-lambda-2,Il28a,IL-28A,Interferon lambda-2,Interleukin-28A,Mouse,Mus musculus 96T
U1689m CLIA Ifnl2,IFN-lambda-2,Il28a,IL-28A,Interferon lambda-2,Interleukin-28A,Mouse,Mus musculus 96T
E1689m ELISA kit Ifnl2,IFN-lambda-2,Il28a,IL-28A,Interferon lambda-2,Interleukin-28A,Mouse,Mus musculus 96T
U2028m CLIA kit Ifnl3,IFN-lambda-3,Il28,Il28b,IL-28B,Interferon lambda-3,Interleukin-28B,Mouse,Mus musculus 96T
E2028m ELISA kit Ifnl3,IFN-lambda-3,Il28,Il28b,IL-28B,Interferon lambda-3,Interleukin-28B,Mouse,Mus musculus 96T
U2028m CLIA Ifnl3,IFN-lambda-3,Il28,Il28b,IL-28B,Interferon lambda-3,Interleukin-28B,Mouse,Mus musculus 96T
E2028m ELISA Ifnl3,IFN-lambda-3,Il28,Il28b,IL-28B,Interferon lambda-3,Interleukin-28B,Mouse,Mus musculus 96T
228-10913-1 Recombinant Human Interleukin-28A (IL-28A) _ Interferon-lambda 2 (IFN-lambda 2) 5
228-10914-1 Recombinant Human Interleukin-29 (IL-29) _ Interferon-lambda 1 (IFN-lambda 1) 5
228-10913-2 Recombinant Human Interleukin-28A (IL-28A) _ Interferon-lambda 2 (IFN-lambda 2) 20
228-10914-2 Recombinant Human Interleukin-29 (IL-29) _ Interferon-lambda 1 (IFN-lambda 1) 20
228-10914-3 Recombinant Human Interleukin-29 (IL-29) _ Interferon-lambda 1 (IFN-lambda 1) 1 mg
orb82616 Human IL29 protein IL28A, IL28B, and IL29, also named interferon lambda2 (IFN lambda 2), IFN lambda 3, and IFN lambda 1, respectively, are newly identified class II cytokine receptor ligands that are 5
IL28RA IL28A Gene interleukin 28A (interferon, lambda 2)


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur