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Interferon regulatory factor 4

 E1BF88_BOVIN            Unreviewed;       454 AA.
E1BF88;
02-NOV-2010, integrated into UniProtKB/TrEMBL.
02-NOV-2010, sequence version 1.
12-SEP-2018, entry version 51.
SubName: Full=Interferon regulatory factor 4 {ECO:0000313|Ensembl:ENSBTAP00000003812};
Name=IRF4 {ECO:0000313|Ensembl:ENSBTAP00000003812,
ECO:0000313|VGNC:VGNC:30275};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000003812, ECO:0000313|Proteomes:UP000009136};
[1] {ECO:0000313|Ensembl:ENSBTAP00000003812, ECO:0000313|Proteomes:UP000009136}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003812,
ECO:0000313|Proteomes:UP000009136};
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2] {ECO:0000313|Ensembl:ENSBTAP00000003812}
IDENTIFICATION.
STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000003812};
Ensembl;
Submitted (MAR-2016) to UniProtKB.
-!- SIMILARITY: Belongs to the IRF family. {ECO:0000256|PROSITE-
ProRule:PRU00840}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00840}.
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EMBL; DAAA02055939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; E1BF88; -.
STRING; 9913.ENSBTAP00000003812; -.
PaxDb; E1BF88; -.
Ensembl; ENSBTAT00000003812; ENSBTAP00000003812; ENSBTAG00000002929.
VGNC; VGNC:30275; IRF4.
eggNOG; ENOG410IES5; Eukaryota.
eggNOG; ENOG411023V; LUCA.
GeneTree; ENSGT00760000119093; -.
InParanoid; E1BF88; -.
OMA; DCRLHIC; -.
OrthoDB; EOG091G067P; -.
TreeFam; TF328512; -.
Proteomes; UP000009136; Chromosome 23.
Bgee; ENSBTAG00000002929; Expressed in 7 organ(s), highest expression level in spleen.
GO; GO:0000788; C:nuclear nucleosome; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0043966; P:histone H3 acetylation; IEA:Ensembl.
GO; GO:0043967; P:histone H4 acetylation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0034122; P:negative regulation of toll-like receptor signaling pathway; IEA:Ensembl.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
GO; GO:0043388; P:positive regulation of DNA binding; IEA:Ensembl.
GO; GO:0045082; P:positive regulation of interleukin-10 biosynthetic process; IEA:Ensembl.
GO; GO:0045368; P:positive regulation of interleukin-13 biosynthetic process; IEA:Ensembl.
GO; GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IEA:Ensembl.
GO; GO:0045404; P:positive regulation of interleukin-4 biosynthetic process; IEA:Ensembl.
GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:Ensembl.
CDD; cd00103; IRF; 1.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.60.200.10; -; 1.
InterPro; IPR019817; Interferon_reg_fac_CS.
InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
InterPro; IPR019471; Interferon_reg_factor-3.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR11949; PTHR11949; 1.
Pfam; PF00605; IRF; 1.
Pfam; PF10401; IRF-3; 1.
PRINTS; PR00267; INTFRNREGFCT.
SMART; SM00348; IRF; 1.
SMART; SM01243; IRF-3; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF49879; SSF49879; 1.
PROSITE; PS00601; IRF_1; 1.
PROSITE; PS51507; IRF_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000009136};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00840};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00840};
Reference proteome {ECO:0000313|Proteomes:UP000009136};
Transcription {ECO:0000256|PROSITE-ProRule:PRU00840};
Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00840}.
DOMAIN 21 129 IRF tryptophan pentad repeat.
{ECO:0000259|PROSITE:PS51507}.
SEQUENCE 454 AA; 51797 MW; 47DF0A179B8A9961 CRC64;
MNLEGGSRGG EFGMSSVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSIF RIPWKHAGKQ
DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD
PYKVYRIVPE GAKKGAKQLT LEDPQMPMSH PYSMPTPYPS LPAQQVHNYM IPPHDRGWRE
FVPDQPHAEI PYQCPVTFGP RGHHWQGPAC ENANAGCQVT GTFYACAPPE SQAPGIPIEP
SIRSAEALAL SDCRLHICLY YREVLVKELT TSSPEGCRIS HGHTYDASSL DQVLFPYPED
SSQRKNIEKL LSHLERGVVL WMAPDGLYAK RLCQSRIYWD GPLAICSDRP NKLERDQTCK
LFDTQQFLSE LQAFAHHGRP LPRFQVTLCF GEEFPDPQRQ RKLITAHVEP LLARQLYYFA
QQNSGHFLRG YDLPEHVGGP EDFHRPPRHS SIQE


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