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Interferon tau (IFN-tau) (Antiluteolysin) (Trophoblast antiluteolytic protein) (Trophoblast protein 1) (TP-1) (Trophoblastin)

 IFNT_OVIMO              Reviewed;         195 AA.
P28172;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
10-MAY-2017, entry version 87.
RecName: Full=Interferon tau;
Short=IFN-tau;
AltName: Full=Antiluteolysin;
AltName: Full=Trophoblast antiluteolytic protein;
AltName: Full=Trophoblast protein 1;
Short=TP-1;
AltName: Full=Trophoblastin;
Flags: Precursor;
Name=IFNT; Synonyms=IFN;
Ovibos moschatus (Muskox).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovibos.
NCBI_TaxID=37176;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1374107; DOI=10.1089/jir.1992.12.1;
Leaman D.W., Roberts R.M.;
"Genes for the trophoblast interferons in sheep, goat, and musk ox and
distribution of related genes among mammals.";
J. Interferon Res. 12:1-11(1992).
[2]
REVIEW.
PubMed=9865498; DOI=10.1016/S0300-9084(99)80029-7;
Martal J.L., Chene N.M., Huynh L.P., L'Haridon R.M., Reinaud P.B.,
Guillomot M.W., Charlier M.A., Charpigny S.Y.;
"IFN-tau: a novel subtype I IFN1. Structural characteristics, non-
ubiquitous expression, structure-function relationships, a pregnancy
hormonal embryonic signal and cross-species therapeutic
potentialities.";
Biochimie 80:755-777(1998).
-!- FUNCTION: Paracrine hormone primarily responsible for maternal
recognition of pregnancy. Interacts with endometrial receptors,
probably type I interferon receptors, and blocks estrogen receptor
expression, preventing the estrogen-induced increase in oxytocin
receptor expression in the endometrium. This results in the
suppression of the pulsatile endometrial release of the luteolytic
hormone prostaglandin F2-alpha, hindering the regression of the
corpus luteum (luteolysis) and therefore a return to ovarian
cyclicity. This, and a possible direct effect of IFN-tau on
prostaglandin synthesis, leads in turn to continued ovarian
progesterone secretion, which stimulates the secretion by the
endometrium of the nutrients required for the growth of the
conceptus. In summary, displays particularly high antiviral and
antiproliferative potency concurrently with particular weak
cytotoxicity, high antiluteolytic activity and immunomodulatory
properties. In contrast with other IFNs, IFN-tau is not virally
inducible.
-!- SUBCELLULAR LOCATION: Secreted. Note=Secreted into the uterine
lumen.
-!- TISSUE SPECIFICITY: Constitutively and exclusively expressed in
the mononuclear cells of the extraembryonic trophectoderm.
-!- DEVELOPMENTAL STAGE: Major secretory product synthesized by the
conceptus during a very short period in early pregnancy.
-!- MISCELLANEOUS: IFN-tau genes are intronless. They evolved from
IFN-omega genes in the ruminantia suborder and have continued to
duplicate independently in different lineages of the ruminantia.
They code for proteins very similar in sequence but with different
biological potency and pattern of expression.
-!- SIMILARITY: Belongs to the alpha/beta interferon family. IFN-
alphaII subfamily. {ECO:0000305}.
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EMBL; M73244; AAA31583.1; -; Genomic_DNA.
ProteinModelPortal; P28172; -.
SMR; P28172; -.
HOVERGEN; HBG052086; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
2: Evidence at transcript level;
Antiviral defense; Cytokine; Disulfide bond; Glycoprotein; Hormone;
Pregnancy; Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 195 Interferon tau.
/FTId=PRO_0000016426.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 24 122 {ECO:0000250}.
DISULFID 52 162 {ECO:0000250}.
SEQUENCE 195 AA; 22370 MW; 39599512F3C34208 CRC64;
MAFVLSLRMA LVLVSYCPGG SLGCYLSRRP TLDVRENLRL LDRMNRLSPH SCQQDRKDFG
LPQEMVEGDQ LQKDQALSVL YEMLQQRFNL FHTEHSCAAW NTTLLEQLRT GLHQQLEDLD
TCRGPVMGEK DSELGKMDPI VTVKKYFQGI YDYLQEKGYS DCAWEIVRVE MMRALTSSTT
LQKRLKKTGG DLNSP


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