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Interferon tau-11 (IFN-tau-11) (Antiluteolysin) (P4) (S4) (Trophoblast antiluteolytic protein) (Trophoblast protein 1) (TP-1) (Trophoblastin)

 IFNTB_SHEEP             Reviewed;         195 AA.
P28169;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
10-MAY-2017, entry version 104.
RecName: Full=Interferon tau-11;
Short=IFN-tau-11;
AltName: Full=Antiluteolysin;
AltName: Full=P4;
AltName: Full=S4;
AltName: Full=Trophoblast antiluteolytic protein;
AltName: Full=Trophoblast protein 1;
Short=TP-1;
AltName: Full=Trophoblastin;
Flags: Precursor;
Name=IFNT11;
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1374107; DOI=10.1089/jir.1992.12.1;
Leaman D.W., Roberts R.M.;
"Genes for the trophoblast interferons in sheep, goat, and musk ox and
distribution of related genes among mammals.";
J. Interferon Res. 12:1-11(1992).
[2]
FUNCTION.
PubMed=8603586; DOI=10.1210/endo.137.3.8603586;
Spencer T.E., Bazer F.W.;
"Ovine interferon tau suppresses transcription of the estrogen
receptor and oxytocin receptor genes in the ovine endometrium.";
Endocrinology 137:1144-1147(1996).
[3]
CIRCULAR DICHROISM ANALYSIS, AND 3D-STRUCTURE MODELING.
PubMed=7971949; DOI=10.1093/protein/7.7.863;
Jarpe M.A., Johnson H.M., Bazer F.W., Ott T.L., Curto E.V.,
Krishna N.R., Pontzer C.H.;
"Predicted structural motif of IFN tau.";
Protein Eng. 7:863-867(1994).
[4]
3D-STRUCTURE MODELING.
PubMed=8746786;
Senda T., Saitoh S., Mitsui Y., Li J., Roberts R.M.;
"A three-dimensional model of interferon-tau.";
J. Interferon Cytokine Res. 15:1053-1060(1995).
[5]
MUTAGENESIS.
PubMed=7929162;
Li J., Roberts R.M.;
"Structure-function relationships in the interferon-tau (IFN-tau).
Changes in receptor binding and in antiviral and antiproliferative
activities resulting from site-directed mutagenesis performed near the
carboxyl terminus.";
J. Biol. Chem. 269:24826-24833(1994).
[6]
MUTAGENESIS.
PubMed=9002652; DOI=10.1095/biolreprod56.1.214;
Niswender K.D., Li J., Powell M.R., Loos K.R., Roberts R.M.,
Keisler D.H., Smith M.F.;
"Effect of variants of interferon-tau with mutations near the carboxyl
terminus on luteal life span in sheep.";
Biol. Reprod. 56:214-220(1997).
[7]
REVIEW.
PubMed=9865498; DOI=10.1016/S0300-9084(99)80029-7;
Martal J.L., Chene N.M., Huynh L.P., L'Haridon R.M., Reinaud P.B.,
Guillomot M.W., Charlier M.A., Charpigny S.Y.;
"IFN-tau: a novel subtype I IFN1. Structural characteristics, non-
ubiquitous expression, structure-function relationships, a pregnancy
hormonal embryonic signal and cross-species therapeutic
potentialities.";
Biochimie 80:755-777(1998).
-!- FUNCTION: Paracrine hormone primarily responsible for maternal
recognition of pregnancy. Interacts with endometrial receptors,
probably type I interferon receptors, and blocks estrogen receptor
expression, preventing the estrogen-induced increase in oxytocin
receptor expression in the endometrium. This results in the
suppression of the pulsatile endometrial release of the luteolytic
hormone prostaglandin F2-alpha, hindering the regression of the
corpus luteum (luteolysis) and therefore a return to ovarian
cyclicity. This, and a possible direct effect of IFN-tau on
prostaglandin synthesis, leads in turn to continued ovarian
progesterone secretion, which stimulates the secretion by the
endometrium of the nutrients required for the growth of the
conceptus. In summary, displays particularly high antiviral and
antiproliferative potency concurrently with particular weak
cytotoxicity, high antiluteolytic activity and immunomodulatory
properties. In contrast with other IFNs, IFN-tau is not virally
inducible. {ECO:0000269|PubMed:8603586}.
-!- SUBCELLULAR LOCATION: Secreted. Note=Secreted into the uterine
lumen.
-!- TISSUE SPECIFICITY: Constitutively and exclusively expressed in
the mononuclear cells of the extraembryonic trophectoderm.
-!- DEVELOPMENTAL STAGE: Major secretory product synthesized by the
sheep conceptus between days 13 and 21 of pregnancy.
-!- MISCELLANEOUS: IFN-tau genes are intronless. They evolved from
IFN-omega genes in the ruminantia suborder and have continued to
duplicate independently in different lineages of the ruminantia.
They code for proteins very similar in sequence but with different
biological potency and pattern of expression.
-!- SIMILARITY: Belongs to the alpha/beta interferon family. IFN-
alphaII subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M73241; AAA31573.1; -; Genomic_DNA.
PIR; I47097; I47097.
PDB; 1OVI; Model; -; A=24-195.
PDBsum; 1OVI; -.
ProteinModelPortal; P28169; -.
SMR; P28169; -.
HOVERGEN; HBG052086; -.
Proteomes; UP000002356; Unplaced.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005126; F:cytokine receptor binding; IEA:InterPro.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
GO; GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.
CDD; cd00095; IFab; 1.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000471; Interferon_alpha/beta/delta.
PANTHER; PTHR11691; PTHR11691; 1.
Pfam; PF00143; Interferon; 1.
PRINTS; PR00266; INTERFERONAB.
SMART; SM00076; IFabd; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00252; INTERFERON_A_B_D; 1.
1: Evidence at protein level;
3D-structure; Antiviral defense; Complete proteome; Cytokine;
Disulfide bond; Glycoprotein; Hormone; Pregnancy; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
CHAIN 24 195 Interferon tau-11.
/FTId=PRO_0000016422.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 24 122 {ECO:0000250}.
DISULFID 52 162 {ECO:0000250}.
MUTAGEN 166 166 I->T: 20-fold reduction in receptor
binding activity, greatly reduces
antiviral and almost abolishes
antiproliferative activity.
MUTAGEN 183 183 Missing: Little effect on receptor
binding activity but greatly reduces
antiviral and almost abolishes
antiproliferative activity.
MUTAGEN 185 195 Missing: Little effect on receptor
binding activity but greatly reduces
antiviral and almost abolishes
antiproliferative activity.
SEQUENCE 195 AA; 22244 MW; DC6321E42BDF948A CRC64;
MAFVLSLLMA LVLVSYGPGG SLGCYLSQRL MLDARENLRL LDRMNRLSPH SCLQDRKDFG
LPQEMVEGDQ LQEAQAFCVL YEMLQQSFNL FHTERSSAAW NTTLLEQLCT GLQQQLEDLD
TCRGPVMGEK DSELGKMDPI VTVKKYFQGI HFYLKEKEYS DCAWEIVRVE MMRALSSSTS
LQERLRKMGG DLNSP


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