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Interferon-induced transmembrane protein 1 (Dispanin subfamily A member 2a) (DSPA2a) (Fragilis protein 2) (Mouse ifitm-like protein 2) (Mil-2)

 IFM1_MOUSE              Reviewed;         106 AA.
Q9D103; Q8R2S7;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
12-SEP-2018, entry version 118.
RecName: Full=Interferon-induced transmembrane protein 1;
AltName: Full=Dispanin subfamily A member 2a;
Short=DSPA2a;
AltName: Full=Fragilis protein 2;
AltName: Full=Mouse ifitm-like protein 2;
Short=Mil-2;
Name=Ifitm1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
PubMed=14516695; DOI=10.1016/S0925-4773(03)00126-6;
Tanaka S.S., Matsui Y.;
"Developmentally regulated expression of mil-1 and mil-2, mouse
interferon-induced transmembrane protein like genes, during formation
and differentiation of primordial germ cells.";
Mech. Dev. 119:S261-S267(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Embryo;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II, and FVB/N;
TISSUE=Colon, Heart, Lung, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=12659663; DOI=10.1186/1471-213X-3-1;
Lange U.C., Saitou M., Western P.S., Barton S.C., Surani M.A.;
"The fragilis interferon-inducible gene family of transmembrane
proteins is associated with germ cell specification in mice.";
BMC Dev. Biol. 3:1-1(2003).
[6]
SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=16326387; DOI=10.1016/j.devcel.2005.10.010;
Tanaka S.S., Yamaguchi Y.L., Tsoi B., Lickert H., Tam P.P.;
"IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct
roles in mouse primordial germ cell homing and repulsion.";
Dev. Cell 9:745-756(2005).
[7]
FUNCTION.
PubMed=18505827; DOI=10.1128/MCB.00272-08;
Lange U.C., Adams D.J., Lee C., Barton S., Schneider R., Bradley A.,
Surani M.A.;
"Normal germ line establishment in mice carrying a deletion of the
Ifitm/Fragilis gene family cluster.";
Mol. Cell. Biol. 28:4688-4696(2008).
[8]
REVIEW.
PubMed=21166591; DOI=10.1089/jir.2010.0112;
Siegrist F., Ebeling M., Certa U.;
"The small interferon-induced transmembrane genes and proteins.";
J. Interferon Cytokine Res. 31:183-197(2011).
[9]
FUNCTION.
PubMed=21253575; DOI=10.1371/journal.ppat.1001258;
Huang I.C., Bailey C.C., Weyer J.L., Radoshitzky S.R., Becker M.M.,
Chiang J.J., Brass A.L., Ahmed A.A., Chi X., Dong L., Longobardi L.E.,
Boltz D., Kuhn J.H., Elledge S.J., Bavari S., Denison M.R., Choe H.,
Farzan M.;
"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS
coronavirus, and influenza A virus.";
PLoS Pathog. 7:E1001258-E1001258(2011).
[10]
GENE FAMILY.
PubMed=22363774; DOI=10.1371/journal.pone.0031961;
Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
"The dispanins: a novel gene family of ancient origin that contains 14
human members.";
PLoS ONE 7:E31961-E31961(2012).
-!- FUNCTION: IFN-induced antiviral protein which inhibits the entry
of viruses to the host cell cytoplasm, permitting endocytosis, but
preventing subsequent viral fusion and release of viral contents
into the cytosol. Active against multiple viruses, including
influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus
(MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus
(WNV). Can inhibit: influenza virus hemagglutinin protein-mediated
viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV
S protein-mediated viral entry. Also implicated in cell adhesion
and control of cell growth and migration. Plays a key role in the
antiproliferative action of IFN-gamma either by inhibiting the ERK
activation or by arresting cell growth in G1 phase in a p53-
dependent manner. Acts as a positive regulator of osteoblast
differentiation. {ECO:0000269|PubMed:18505827,
ECO:0000269|PubMed:21253575}.
-!- SUBUNIT: Interacts with CAV1; this interaction enhances the
ability of CAV1 in inhibiting ERK activation. Interacts with CD81.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16326387};
Single-pass membrane protein {ECO:0000269|PubMed:16326387}.
-!- TISSUE SPECIFICITY: Predominantly expressed in nascent primordial
germ cells, as well as in gonadal germ cells.
{ECO:0000269|PubMed:12659663}.
-!- DEVELOPMENTAL STAGE: In migrating PGCs, expression is first
detected during germ cell differentiation.
{ECO:0000269|PubMed:14516695, ECO:0000269|PubMed:16326387}.
-!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
-!- CAUTION: It has been previously shown that mediates migration of
early primordial germ cells (PGCs) (PubMed:16326387). But
according to PubMed:16326387, have no detectable effects on
development of the germ line or on the generation of live young,
hence, is not essential for PGC migration.
{ECO:0000305|PubMed:16326387}.
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EMBL; AK004121; BAB23181.1; -; mRNA.
EMBL; AK169960; BAE41483.1; -; mRNA.
EMBL; CH466531; EDL17976.1; -; Genomic_DNA.
EMBL; BC027285; AAH27285.1; -; mRNA.
EMBL; BC090258; AAH90258.1; -; mRNA.
EMBL; BC090972; AAH90972.1; -; mRNA.
EMBL; BK001123; DAA01238.1; -; mRNA.
CCDS; CCDS21995.1; -.
RefSeq; NP_001106186.1; NM_001112715.1.
RefSeq; NP_081096.3; NM_026820.3.
RefSeq; XP_006536301.1; XM_006536238.1.
UniGene; Mm.175661; -.
DIP; DIP-60824N; -.
IntAct; Q9D103; 1.
STRING; 10090.ENSMUSP00000026564; -.
PhosphoSitePlus; Q9D103; -.
SwissPalm; Q9D103; -.
EPD; Q9D103; -.
MaxQB; Q9D103; -.
PaxDb; Q9D103; -.
PRIDE; Q9D103; -.
Ensembl; ENSMUST00000026564; ENSMUSP00000026564; ENSMUSG00000025491.
Ensembl; ENSMUST00000106040; ENSMUSP00000101655; ENSMUSG00000025491.
Ensembl; ENSMUST00000106042; ENSMUSP00000101657; ENSMUSG00000025491.
GeneID; 68713; -.
KEGG; mmu:68713; -.
UCSC; uc009kja.2; mouse.
CTD; 8519; -.
MGI; MGI:1915963; Ifitm1.
eggNOG; ENOG410J2DU; Eukaryota.
eggNOG; ENOG4112C1U; LUCA.
GeneTree; ENSGT00390000003476; -.
HOGENOM; HOG000115781; -.
HOVERGEN; HBG001182; -.
InParanoid; Q9D103; -.
KO; K19831; -.
OMA; MINIQSE; -.
OrthoDB; EOG091G1143; -.
PhylomeDB; Q9D103; -.
TreeFam; TF334894; -.
Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
PRO; PR:Q9D103; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000025491; Expressed in 244 organ(s), highest expression level in conjunctival fornix.
Genevisible; Q9D103; MM.
GO; GO:0005769; C:early endosome; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
GO; GO:0051607; P:defense response to virus; IDA:MGI.
GO; GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB.
GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
GO; GO:0035455; P:response to interferon-alpha; ISS:UniProtKB.
GO; GO:0035456; P:response to interferon-beta; ISS:UniProtKB.
GO; GO:0034341; P:response to interferon-gamma; ISS:UniProtKB.
GO; GO:0009615; P:response to virus; IDA:UniProtKB.
GO; GO:0001756; P:somitogenesis; IMP:MGI.
InterPro; IPR007593; CD225/Dispanin_fam.
Pfam; PF04505; CD225; 1.
2: Evidence at transcript level;
Antiviral defense; Cell membrane; Complete proteome; Immunity;
Innate immunity; Lipoprotein; Membrane; Osteogenesis; Palmitate;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 106 Interferon-induced transmembrane protein
1.
/FTId=PRO_0000398565.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000255}.
INTRAMEM 36 56 Helical. {ECO:0000250|UniProtKB:P13164}.
TOPO_DOM 57 84 Cytoplasmic. {ECO:0000255}.
TRANSMEM 85 105 Helical. {ECO:0000255}.
TOPO_DOM 106 106 Extracellular. {ECO:0000255}.
LIPID 49 49 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 50 50 S-palmitoyl cysteine. {ECO:0000250}.
LIPID 83 83 S-palmitoyl cysteine. {ECO:0000250}.
CONFLICT 37 37 V -> I (in Ref. 3; AAH27285).
{ECO:0000305}.
CONFLICT 54 54 V -> I (in Ref. 3; AAH27285).
{ECO:0000305}.
SEQUENCE 106 AA; 11524 MW; 7B0E7D8200D36631 CRC64;
MPKEQQEVVV LGSPHISTSA TATTINMPEI STPDHVVWSL FNTLFMNFCC LGFVAYAYSV
KSRDRKMVGD TTGAQAFAST AKCLNISSLF FTILTAIVVI VVCAIR


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