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Interleukin-10 (IL-10)

 IL10_CHICK              Reviewed;         175 AA.
Q6A2H4; Q6A2H5;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
24-JUL-2007, sequence version 2.
10-OCT-2018, entry version 111.
RecName: Full=Interleukin-10;
Short=IL-10;
Flags: Precursor;
Name=IL10 {ECO:0000312|EMBL:CAF21727.1};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1] {ECO:0000305, ECO:0000312|EMBL:CAF21727.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND TISSUE
SPECIFICITY.
TISSUE=Cecum {ECO:0000269|PubMed:15294985};
PubMed=15294985; DOI=10.4049/jimmunol.173.4.2675;
Rothwell L., Young J.R., Zoorob R., Whittaker C.A., Hesketh P.,
Archer A., Smith A.L., Kaiser P.;
"Cloning and characterization of chicken IL-10 and its role in the
immune response to Eimeria maxima.";
J. Immunol. 173:2675-2682(2004).
[2] {ECO:0000305}
NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
PubMed=15932414; DOI=10.1111/j.1365-2052.2005.01264.x;
Yilmaz A., Shen S., Adelson D.L., Xavier S., Zhu J.;
"Annotation of the chicken IL10 gene cluster and effects of
lipopolysaccharide stimulation on IL10 gene expression.";
Anim. Genet. 36:263-265(2005).
[3] {ECO:0000305}
INDUCTION.
PubMed=16996141; DOI=10.1016/j.vetimm.2006.07.007;
Hong Y.H., Lillehoj H.S., Lee S.H., Dalloul R.A., Lillehoj E.P.;
"Analysis of chicken cytokine and chemokine gene expression following
Eimeria acervulina and Eimeria tenella infections.";
Vet. Immunol. Immunopathol. 114:209-223(2006).
[4] {ECO:0000305}
INDUCTION.
PubMed=17045659; DOI=10.1016/j.vetimm.2006.08.006;
Hong Y.H., Lillehoj H.S., Lillehoj E.P., Lee S.H.;
"Changes in immune-related gene expression and intestinal lymphocyte
subpopulations following Eimeria maxima infection of chickens.";
Vet. Immunol. Immunopathol. 114:259-272(2006).
[5] {ECO:0000305}
DEVELOPMENTAL STAGE.
PubMed=17575181; DOI=10.1093/ps/86.7.1351;
Abdul-Careem M.F., Hunter D.B., Lambourne M.D., Barta J., Sharif S.;
"Ontogeny of cytokine gene expression in the chicken spleen.";
Poult. Sci. 86:1351-1355(2007).
-!- FUNCTION: Inhibits the synthesis of a number of cytokines,
including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
activated macrophages and by helper T-cells.
{ECO:0000250|UniProtKB:P22301, ECO:0000269|PubMed:15294985}.
-!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P22301}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P22301}.
-!- TISSUE SPECIFICITY: Expressed predominantly in bursa of Fabricius
and cecal tonsils with low levels in thymus, liver and lung.
{ECO:0000269|PubMed:15294985}.
-!- DEVELOPMENTAL STAGE: Expression is detected as early as embryonic
day 12. Higher expression in spleen of post-hatch chickens than
embryos. Gradual increase in expression in the spleen which peaks
by day 7 post-hatch. {ECO:0000269|PubMed:17575181}.
-!- INDUCTION: By lipopolysaccharide (LPS) in white blood cells, liver
and spleen 3 hours after treatment. Decreases to basal levels 8
hours after treatment. By primary infection with E.acervulina and
E.tenella. {ECO:0000269|PubMed:15932414,
ECO:0000269|PubMed:16996141, ECO:0000269|PubMed:17045659}.
-!- MISCELLANEOUS: Chickens susceptible to E.maxima infection show
higher constitutive and post-infection levels in spleen and higher
post-infection levels in small intestine than infection-resistant
animals. {ECO:0000269|PubMed:15294985}.
-!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000255}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AJ621614; CAF21727.1; -; Genomic_DNA.
EMBL; AJ621254; CAF18432.1; -; mRNA.
EMBL; AY647438; -; NOT_ANNOTATED_CDS; mRNA.
RefSeq; NP_001004414.2; NM_001004414.2.
UniGene; Gga.46641; -.
ProteinModelPortal; Q6A2H4; -.
SMR; Q6A2H4; -.
STRING; 9031.ENSGALP00000001310; -.
PaxDb; Q6A2H4; -.
Ensembl; ENSGALT00000001312; ENSGALP00000001310; ENSGALG00000000892.
GeneID; 428264; -.
KEGG; gga:428264; -.
CTD; 3586; -.
eggNOG; ENOG410IYFW; Eukaryota.
eggNOG; ENOG4111PXC; LUCA.
GeneTree; ENSGT00510000048535; -.
HOGENOM; HOG000072692; -.
HOVERGEN; HBG004110; -.
InParanoid; Q6A2H4; -.
KO; K05443; -.
OMA; PHMLREL; -.
OrthoDB; EOG091G0Y3M; -.
PhylomeDB; Q6A2H4; -.
Reactome; R-GGA-6783783; Interleukin-10 signaling.
PRO; PR:Q6A2H4; -.
Proteomes; UP000000539; Chromosome 26.
Bgee; ENSGALG00000000892; Expressed in 2 organ(s), highest expression level in liver.
ExpressionAtlas; Q6A2H4; baseline and differential.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IDA:UniProtKB.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0002875; P:negative regulation of chronic inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0060302; P:negative regulation of cytokine activity; IEA:Ensembl.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Ensembl.
GO; GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IEA:Ensembl.
GO; GO:0045077; P:negative regulation of interferon-gamma biosynthetic process; IDA:UniProtKB.
GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032715; P:negative regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IEA:Ensembl.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:UniProtKB.
GO; GO:0002826; P:negative regulation of T-helper 1 type immune response; IC:UniProtKB.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:1904706; P:negative regulation of vascular smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0002904; P:positive regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0045787; P:positive regulation of cell cycle; IEA:Ensembl.
GO; GO:0050715; P:positive regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1903672; P:positive regulation of sprouting angiogenesis; IEA:Ensembl.
GO; GO:0032800; P:receptor biosynthetic process; IEA:Ensembl.
GO; GO:1903034; P:regulation of response to wounding; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000098; IL-10.
InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
Pfam; PF00726; IL10; 1.
PRINTS; PR01294; INTRLEUKIN10.
SMART; SM00188; IL10; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Reference proteome;
Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 175 Interleukin-10. {ECO:0000255}.
/FTId=PRO_0000296319.
DISULFID 26 123 {ECO:0000250|UniProtKB:P22301}.
DISULFID 77 129 {ECO:0000250|UniProtKB:P22301}.
CONFLICT 120 120 M -> I (in Ref. 1; CAF21727).
{ECO:0000305}.
SEQUENCE 175 AA; 20514 MW; B0966EBEAFDFB050 CRC64;
MQTCCQALLL LLAACTLPAH CLEPTCLHFS ELLPARLREL RVKFEEIKDY FQSRDDELNI
QLLSSELLDE FKGTFGCQSV SEMLRFYTDE VLPRAMQTST SHQQSMGDLG NMLLGLKATM
RRCHRFFTCE KRSKAIKQIK ETFEKMDENG IYKAMGEFDI FINYIEEYLL MRRRK


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