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Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)

 IL10_RAT                Reviewed;         178 AA.
P29456; Q63263;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
28-MAR-2018, entry version 127.
RecName: Full=Interleukin-10;
Short=IL-10;
AltName: Full=Cytokine synthesis inhibitory factor;
Short=CSIF;
Flags: Precursor;
Name=Il10; Synonyms=Il-10;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1280414; DOI=10.1016/0006-291X(92)91516-S;
Goodman R.E., Oblak J., Bell R.G.;
"Synthesis and characterization of rat interleukin-10 (IL-10) cDNA
clones from the RNA of cultured OX8-OX22-thoracic duct T cells.";
Biochem. Biophys. Res. Commun. 189:1-7(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Fischer 344; TISSUE=Macrophage;
PubMed=8484757; DOI=10.1006/bbrc.1993.1436;
Feng L., Tang W.W., Chang J.C.C., Wilson C.B.;
"Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10)
cDNA and expression in spleen and macrophages.";
Biochem. Biophys. Res. Commun. 192:452-458(1993).
-!- FUNCTION: Inhibits the synthesis of a number of cytokines,
including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
activated macrophages and by helper T-cells. {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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EMBL; L02926; AAA41425.1; -; mRNA.
EMBL; X60675; CAA43090.1; -; mRNA.
PIR; JN0475; JN0475.
RefSeq; NP_036986.2; NM_012854.2.
UniGene; Rn.9868; -.
ProteinModelPortal; P29456; -.
SMR; P29456; -.
STRING; 10116.ENSRNOP00000006246; -.
PaxDb; P29456; -.
PRIDE; P29456; -.
Ensembl; ENSRNOT00000006246; ENSRNOP00000006246; ENSRNOG00000004647.
GeneID; 25325; -.
KEGG; rno:25325; -.
UCSC; RGD:2886; rat.
CTD; 3586; -.
RGD; 2886; Il10.
eggNOG; ENOG410IYFW; Eukaryota.
eggNOG; ENOG4111PXC; LUCA.
GeneTree; ENSGT00510000048535; -.
HOGENOM; HOG000072692; -.
HOVERGEN; HBG004110; -.
InParanoid; P29456; -.
KO; K05443; -.
OMA; PHMLREL; -.
OrthoDB; EOG091G0Y3M; -.
PhylomeDB; P29456; -.
TreeFam; TF333253; -.
Reactome; R-RNO-6783783; Interleukin-10 signaling.
PRO; PR:P29456; -.
Proteomes; UP000002494; Chromosome 13.
Bgee; ENSRNOG00000004647; -.
Genevisible; P29456; RN.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005125; F:cytokine activity; ISO:RGD.
GO; GO:0005141; F:interleukin-10 receptor binding; IDA:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; ISO:RGD.
GO; GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD.
GO; GO:0035729; P:cellular response to hepatocyte growth factor stimulus; ISO:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
GO; GO:0042832; P:defense response to protozoan; ISO:RGD.
GO; GO:0006955; P:immune response; IMP:RGD.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0097421; P:liver regeneration; IEP:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell proliferation; ISO:RGD.
GO; GO:0002875; P:negative regulation of chronic inflammatory response to antigenic stimulus; ISO:RGD.
GO; GO:0060302; P:negative regulation of cytokine activity; ISO:RGD.
GO; GO:0001818; P:negative regulation of cytokine production; IMP:RGD.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; ISO:RGD.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; ISO:RGD.
GO; GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISO:RGD.
GO; GO:1903208; P:negative regulation of hydrogen peroxide-induced neuron death; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IDA:RGD.
GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
GO; GO:0032695; P:negative regulation of interleukin-12 production; ISO:RGD.
GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; ISO:RGD.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IDA:RGD.
GO; GO:1904057; P:negative regulation of sensory perception of pain; IDA:RGD.
GO; GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; IDA:RGD.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:RGD.
GO; GO:1904706; P:negative regulation of vascular smooth muscle cell proliferation; ISO:RGD.
GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
GO; GO:0045787; P:positive regulation of cell cycle; ISO:RGD.
GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISS:UniProtKB.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:0043032; P:positive regulation of macrophage activation; IDA:RGD.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
GO; GO:1903034; P:regulation of response to wounding; ISO:RGD.
GO; GO:0051930; P:regulation of sensory perception of pain; IDA:RGD.
GO; GO:0050807; P:regulation of synapse organization; IDA:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0034465; P:response to carbon monoxide; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0014854; P:response to inactivity; IEP:RGD.
GO; GO:0032868; P:response to insulin; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000098; IL-10.
InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
InterPro; IPR020423; IL-10_CS.
Pfam; PF00726; IL10; 1.
PRINTS; PR01294; INTRLEUKIN10.
SMART; SM00188; IL10; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00520; INTERLEUKIN_10; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 18 {ECO:0000255}.
CHAIN 19 178 Interleukin-10.
/FTId=PRO_0000015372.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 134 134 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 30 126 {ECO:0000250}.
DISULFID 80 132 {ECO:0000250}.
CONFLICT 2 2 P -> L (in Ref. 2; CAA43090).
{ECO:0000305}.
CONFLICT 65 65 L -> V (in Ref. 2; CAA43090).
{ECO:0000305}.
SEQUENCE 178 AA; 20426 MW; 0225AA6C63DAB70B CRC64;
MPGSALLCCL LLLAGVKTSK GHSIRGDNNC THFPVSQTHM LRELRAAFSQ VKTFFQKKDQ
LDNILLTDSL LQDFKGYLGC QALSEMIKFY LVEVMPQAEN HGPEIKEHLN SLGEKLKTLW
IQLRRCHRFL PCENKSKAVE QVKNDFNKLQ DKGVYKAMNE FDIFINCIEA YVTLKMKN


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