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Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF)

 IL10_CANLF              Reviewed;         181 AA.
P48411;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
31-JAN-2018, entry version 99.
RecName: Full=Interleukin-10;
Short=IL-10;
AltName: Full=Cytokine synthesis inhibitory factor;
Short=CSIF;
Flags: Precursor;
Name=IL10;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=8746793;
Lu P., Zucker K., Fuller L., Tzakis A., Esquenazi V., Miller J.;
"Cloning and expression of canine interleukin-10.";
J. Interferon Cytokine Res. 15:1103-1109(1995).
-!- FUNCTION: Inhibits the synthesis of a number of cytokines,
including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
activated macrophages and by helper T-cells. {ECO:0000250}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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EMBL; U33843; AAA76694.1; -; mRNA.
RefSeq; NP_001003077.1; NM_001003077.1.
UniGene; Cfa.38; -.
ProteinModelPortal; P48411; -.
SMR; P48411; -.
STRING; 9615.ENSCAFP00000016812; -.
PaxDb; P48411; -.
GeneID; 403628; -.
KEGG; cfa:403628; -.
CTD; 3586; -.
eggNOG; ENOG410IYFW; Eukaryota.
eggNOG; ENOG4111PXC; LUCA.
HOGENOM; HOG000072692; -.
HOVERGEN; HBG004110; -.
InParanoid; P48411; -.
KO; K05443; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005141; F:interleukin-10 receptor binding; NAS:UniProtKB.
GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; NAS:UniProtKB.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
GO; GO:0051091; P:positive regulation of DNA binding transcription factor activity; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
GO; GO:0051384; P:response to glucocorticoid; ISS:UniProtKB.
GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR000098; IL-10.
InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
InterPro; IPR020423; IL-10_CS.
Pfam; PF00726; IL10; 1.
PRINTS; PR01294; INTRLEUKIN10.
SMART; SM00188; IL10; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00520; INTERLEUKIN_10; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Reference proteome; Secreted; Signal.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 181 Interleukin-10.
/FTId=PRO_0000015354.
CARBOHYD 137 137 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 31 129 {ECO:0000250}.
DISULFID 81 135 {ECO:0000250}.
SEQUENCE 181 AA; 20906 MW; 8BF83ADAFDAE8ADD CRC64;
MHGSALLCCC LVLLAGVGAS RHQSTLLEDD CTHFPASLPH MLRELRAAFG RVKIFFQMKD
KLDNILLTGS LLEDFKSYLG CQALSEMIQF YLEEVMPRAE NHDPDIKNHV NSLGEKLKTL
RLRLRLRRCH RFLPCENKSK AVEQVKSAFS KLQEKGVYKA MSEFDIFINY IETYMTMRMK
I


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