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Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40)

 IL12B_MOUSE             Reviewed;         335 AA.
P43432; Q9QUM1;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
05-JUL-2017, entry version 154.
RecName: Full=Interleukin-12 subunit beta;
Short=IL-12B;
AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit;
Short=CLMF p40;
AltName: Full=IL-12 subunit p40;
Flags: Precursor;
Name=Il12b;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=1350290;
Schoenhaut D.S., Chua A.O., Wolitzky A.G., Quinn P.M., Dwyer C.M.,
Gately M.K., Gubler U.;
"Cloning and expression of murine IL-12.";
J. Immunol. 148:3433-3440(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8647196; DOI=10.1002/eji.1830260606;
Tone Y., Thompson S.A., Babik J.M., Nolan K.F., Tone M., Raven C.,
Waldmann H.;
"Structure and chromosomal location of the mouse interleukin-12 p35
and p40 subunit genes.";
Eur. J. Immunol. 26:1222-1227(1996).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS THR-169 AND LEU-294.
STRAIN=B10.S/J, and SJL/J; TISSUE=Spleen;
PubMed=10438970;
Teuscher C., Butterfield R.J., Ma R.Z., Zachary J.F., Doerge R.W.,
Blankenhorn E.P.;
"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2
(monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are
candidates for eae7, a locus controlling susceptibility to monophasic
remitting/nonrelapsing experimental allergic encephalomyelitis.";
J. Immunol. 163:2262-2266(1999).
[4]
FUNCTION, AND INTERACTION WITH IL23A.
PubMed=11114383; DOI=10.1016/S1074-7613(00)00070-4;
Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F.,
Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T.,
Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J., Abrams J.S.,
Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F.,
Kastelein R.A.;
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with
biological activities similar as well as distinct from IL-12.";
Immunity 13:715-725(2000).
-!- FUNCTION: Cytokine that can act as a growth factor for activated T
and NK cells, enhance the lytic activity of NK/lymphokine-
activated killer cells, and stimulate the production of IFN-gamma
by resting PBMC. {ECO:0000250}.
-!- FUNCTION: Associates with IL23A to form the IL-23 interleukin, a
heterodimeric cytokine which functions in innate and adaptive
immunity. IL-23 may constitute with IL-17 an acute response to
infection in peripheral tissues. IL-23 binds to a heterodimeric
receptor complex composed of IL12RB1 and IL23R, activates the Jak-
Stat signaling cascade, stimulates memory rather than naive T-
cells and promotes production of proinflammatory cytokines. IL-23
induces autoimmune inflammation and thus may be responsible for
autoimmune inflammatory diseases and may be important for
tumorigenesis. {ECO:0000269|PubMed:11114383}.
-!- SUBUNIT: Heterodimer with IL12A; disulfide-linked. The heterodimer
is known as interleukin IL-12. Heterodimer with IL23A; disulfide-
linked. The heterodimer is known as interleukin IL-23. Also
secreted as a monomer.
-!- INTERACTION:
Q9EQ14:Il23a; NbExp=3; IntAct=EBI-2481353, EBI-2481329;
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M86671; AAA39296.1; -; mRNA.
EMBL; S82426; AAB37383.1; -; Genomic_DNA.
EMBL; S82421; AAB37383.1; JOINED; Genomic_DNA.
EMBL; S82422; AAB37383.1; JOINED; Genomic_DNA.
EMBL; S82424; AAB37383.1; JOINED; Genomic_DNA.
EMBL; S82425; AAB37383.1; JOINED; Genomic_DNA.
EMBL; AF128214; AAF22555.1; -; mRNA.
EMBL; AF128215; AAF22556.1; -; mRNA.
CCDS; CCDS24563.1; -.
PIR; I72789; I72789.
RefSeq; NP_001290173.1; NM_001303244.1.
UniGene; Mm.239707; -.
ProteinModelPortal; P43432; -.
SMR; P43432; -.
DIP; DIP-6013N; -.
IntAct; P43432; 1.
STRING; 10090.ENSMUSP00000099860; -.
ChEMBL; CHEMBL2176814; -.
iPTMnet; P43432; -.
PhosphoSitePlus; P43432; -.
PaxDb; P43432; -.
PRIDE; P43432; -.
Ensembl; ENSMUST00000102796; ENSMUSP00000099860; ENSMUSG00000004296.
Ensembl; ENSMUST00000170513; ENSMUSP00000125867; ENSMUSG00000004296.
GeneID; 16160; -.
KEGG; mmu:16160; -.
UCSC; uc007inc.2; mouse.
CTD; 3593; -.
MGI; MGI:96540; Il12b.
eggNOG; ENOG410IF5K; Eukaryota.
eggNOG; ENOG410YWXR; LUCA.
GeneTree; ENSGT00390000012630; -.
HOGENOM; HOG000113027; -.
HOVERGEN; HBG052094; -.
InParanoid; P43432; -.
KO; K05425; -.
OMA; WSTPHSY; -.
OrthoDB; EOG091G0EKV; -.
PhylomeDB; P43432; -.
TreeFam; TF334829; -.
Reactome; R-MMU-447115; Interleukin-12 family signaling.
PRO; PR:P43432; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000004296; -.
CleanEx; MM_IL12B; -.
ExpressionAtlas; P43432; baseline and differential.
Genevisible; P43432; MM.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0043514; C:interleukin-12 complex; IDA:MGI.
GO; GO:0070743; C:interleukin-23 complex; IDA:BHF-UCL.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0042164; F:interleukin-12 alpha subunit binding; IPI:MGI.
GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0007050; P:cell cycle arrest; ISO:MGI.
GO; GO:0016477; P:cell migration; ISO:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI.
GO; GO:0071346; P:cellular response to interferon-gamma; IDA:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:MGI.
GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI.
GO; GO:0042832; P:defense response to protozoan; IDA:MGI.
GO; GO:0051607; P:defense response to virus; IDA:MGI.
GO; GO:0030101; P:natural killer cell activation; ISS:UniProtKB.
GO; GO:0002323; P:natural killer cell activation involved in immune response; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IMP:MGI.
GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IMP:MGI.
GO; GO:0032693; P:negative regulation of interleukin-10 production; ISO:MGI.
GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:MGI.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISO:MGI.
GO; GO:0045785; P:positive regulation of cell adhesion; ISO:MGI.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IDA:BHF-UCL.
GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:MGI.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:MGI.
GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:MGI.
GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:MGI.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISO:MGI.
GO; GO:0032946; P:positive regulation of mononuclear cell proliferation; ISO:MGI.
GO; GO:0032816; P:positive regulation of natural killer cell activation; ISO:MGI.
GO; GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; ISO:MGI.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:MGI.
GO; GO:0051135; P:positive regulation of NK T cell activation; ISO:MGI.
GO; GO:0051142; P:positive regulation of NK T cell proliferation; ISO:MGI.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISO:MGI.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; ISO:MGI.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:BHF-UCL.
GO; GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI.
GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IDA:BHF-UCL.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:MGI.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
GO; GO:0010033; P:response to organic substance; IDA:MGI.
GO; GO:0010224; P:response to UV-B; ISO:MGI.
GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl.
GO; GO:0042093; P:T-helper cell differentiation; ISS:UniProtKB.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR015528; IL-12_beta.
InterPro; IPR019482; IL-12_beta_cen-dom.
PANTHER; PTHR10078:SF37; PTHR10078:SF37; 1.
Pfam; PF10420; IL12p40_C; 1.
PIRSF; PIRSF038007; IL_12_beta; 1.
PRINTS; PR01928; INTRLEUKN12B.
SMART; SM00408; IGc2; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
PROSITE; PS50835; IG_LIKE; 1.
1: Evidence at protein level;
Complete proteome; Cytokine; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Polymorphism; Reference proteome; Secreted;
Signal.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 335 Interleukin-12 subunit beta.
/FTId=PRO_0000010933.
DOMAIN 23 106 Ig-like C2-type.
DOMAIN 233 324 Fibronectin type-III.
COMPBIAS 155 159 Poly-Ser.
CARBOHYD 47 47 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 122 122 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 132 132 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 220 220 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 50 90 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 197 197 Interchain (with C-92 in IL12A).
{ECO:0000255|PROSITE-ProRule:PRU00114}.
VARIANT 169 169 M -> T (in strain: B10.S/J and SJL/J).
{ECO:0000269|PubMed:10438970}.
VARIANT 294 294 F -> L (in strain: B10.S/J and SJL/J).
{ECO:0000269|PubMed:10438970}.
SEQUENCE 335 AA; 38235 MW; 19E4FA5EF0CFC82A CRC64;
MCPQKLTISW FAIVLLVSPL MAMWELEKDV YVVEVDWTPD APGETVNLTC DTPEEDDITW
TSDQRHGVIG SGKTLTITVK EFLDAGQYTC HKGGETLSHS HLLLHKKENG IWSTEILKNF
KNKTFLKCEA PNYSGRFTCS WLVQRNMDLK FNIKSSSSSP DSRAVTCGMA SLSAEKVTLD
QRDYEKYSVS CQEDVTCPTA EETLPIELAL EARQQNKYEN YSTSFFIRDI IKPDPPKNLQ
MKPLKNSQVE VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK MKETEEGCNQ KGAFLVEKTS
TEVQCKGGNV CVQAQDRYYN SSCSKWACVP CRVRS


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