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Interleukin-12 subunit beta (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (IL-12 subunit p40)

 F1PK70_CANLF            Unreviewed;       331 AA.
F1PK70;
03-MAY-2011, integrated into UniProtKB/TrEMBL.
03-MAY-2011, sequence version 1.
12-SEP-2018, entry version 55.
RecName: Full=Interleukin-12 subunit beta {ECO:0000256|RuleBase:RU281113};
Short=IL-12B {ECO:0000256|RuleBase:RU281113};
AltName: Full=Cytotoxic lymphocyte maturation factor 40 kDa subunit {ECO:0000256|RuleBase:RU281113};
AltName: Full=IL-12 subunit p40 {ECO:0000256|RuleBase:RU281113};
Name=IL12B {ECO:0000256|RuleBase:RU281113,
ECO:0000313|Ensembl:ENSCAFP00000025465, ECO:0000313|VGNC:VGNC:41933};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000025465, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000025465, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000025465,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000025465}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000025465};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Cytokine that can act as a growth factor for activated T
and NK cells, enhance the lytic activity of NK/lymphokine-
activated killer cells, and stimulate the production of IFN-gamma
by resting PBMC. {ECO:0000256|RuleBase:RU281113}.
-!- SUBUNIT: Heterodimer with IL12A; disulfide-linked. The heterodimer
is known as interleukin IL-12. {ECO:0000256|RuleBase:RU281113}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU281113}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000256|RuleBase:RU281113}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AAEX03003057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
ProteinModelPortal; F1PK70; -.
Ensembl; ENSCAFT00000027382; ENSCAFP00000025465; ENSCAFG00000017287.
VGNC; VGNC:41933; IL12B.
eggNOG; ENOG410IF5K; Eukaryota.
eggNOG; ENOG410YWXR; LUCA.
GeneTree; ENSGT00390000012630; -.
OMA; WSTPHSY; -.
OrthoDB; EOG091G0EKV; -.
TreeFam; TF334829; -.
Reactome; R-CFA-9020591; Interleukin-12 signaling.
Reactome; R-CFA-9020933; Interleukin-23 signaling.
Proteomes; UP000002254; Chromosome 4.
Bgee; ENSCAFG00000017287; Expressed in 2 organ(s), highest expression level in liver.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0043514; C:interleukin-12 complex; IEA:Ensembl.
GO; GO:0070743; C:interleukin-23 complex; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0004896; F:cytokine receptor activity; IEA:UniProtKB-UniRule.
GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
GO; GO:0042164; F:interleukin-12 alpha subunit binding; IEA:Ensembl.
GO; GO:0045519; F:interleukin-23 receptor binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0032609; P:interferon-gamma production; IEA:Ensembl.
GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:Ensembl.
GO; GO:0002862; P:negative regulation of inflammatory response to antigenic stimulus; IEA:Ensembl.
GO; GO:0032693; P:negative regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
GO; GO:0045672; P:positive regulation of osteoclast differentiation; IEA:Ensembl.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl.
GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IEA:Ensembl.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0010224; P:response to UV-B; IEA:Ensembl.
GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl.
GO; GO:0042093; P:T-helper cell differentiation; IEA:Ensembl.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR015528; IL-12_beta.
InterPro; IPR019482; IL-12_beta_cen-dom.
PANTHER; PTHR44982; PTHR44982; 1.
Pfam; PF10420; IL12p40_C; 1.
PIRSF; PIRSF038007; IL_12_beta; 1.
PRINTS; PR01928; INTRLEUKN12B.
SMART; SM00408; IGc2; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
PROSITE; PS50835; IG_LIKE; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002254};
Cytokine {ECO:0000256|RuleBase:RU281113};
Glycoprotein {ECO:0000256|RuleBase:RU281113};
Immunoglobulin domain {ECO:0000256|RuleBase:RU281113};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Secreted {ECO:0000256|RuleBase:RU281113};
Signal {ECO:0000256|RuleBase:RU281113}.
SIGNAL 1 22 {ECO:0000256|RuleBase:RU281113}.
CHAIN 23 331 Interleukin-12 subunit beta.
{ECO:0000256|RuleBase:RU281113}.
/FTId=PRO_5009366605.
DOMAIN 43 90 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 240 331 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
SEQUENCE 331 AA; 37617 MW; BB834A39B6D09FC6 CRC64;
MHPQQLVISW FSLVLLASPL MAIWELEKDV YVVELDWHPD APGEMVVLTC HTPEEDDITW
TSAQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGKVLSRS LLLIHKKEDG IWSTDILKEQ
KDPESKNKIF LKCEAKNYSG RFTCWWLTAI STDLKFSVKS SRGFSDPQGV TCGAVTLSAE
RVRVDNRDYK KYTVECQEGS ACPSAEESLP IEVVVDAIHK LKYENYTSSF FIRDIIKPDP
PTNLQLKPLK NSRHVEVSWE YPDTWSTPHS YFSLTFCIQA QGKNNREKKD RLCVDKTSAK
VVCHKDAKIR VQARDRYYSS SWSDWASVSC S


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