Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

 IL18_RAT                Reviewed;         194 AA.
P97636; O88749; P97637; Q541E6;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
22-NOV-2017, entry version 128.
RecName: Full=Interleukin-18;
Short=IL-18;
AltName: Full=Interferon gamma-inducing factor;
Short=IFN-gamma-inducing factor;
AltName: Full=Interleukin-1 gamma;
Short=IL-1 gamma;
Flags: Precursor;
Name=Il18; Synonyms=Igif;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
STRAIN=Sprague-Dawley; TISSUE=Adrenal gland;
PubMed=8999896; DOI=10.1074/jbc.272.4.2035;
Conti B., Jahng J.W., Tinti C., Son J.H., Joh T.H.;
"Induction of interferon-gamma inducing factor in the adrenal
cortex.";
J. Biol. Chem. 272:2035-2037(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=9702748; DOI=10.1038/sj.mp.4000389;
Culhane A.C., Hall M.D., Rothwell N.J., Luheshi G.N.;
"Cloning of rat brain interleukin-18 cDNA.";
Mol. Psychiatry 3:362-366(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
STRAIN=New England Deaconess Hospital; TISSUE=Adrenal gland;
Kim S.-J., Kim C.-S., Song K.-Y., Kim J.-S., Jung K.-S.;
"Cloning of the cDNA for interleukin-18 in PC12 and expression in
Escherichia coli.";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BETA).
STRAIN=Fischer 344;
PubMed=12787406; DOI=10.1046/j.1523-1755.2003.00077.x;
Garcia G.E., Xia Y., Ku G., Johnson R.J., Wilson C.B., Feng L.;
"IL-18 translational inhibition restricts IFN-gamma expression in
crescentic glomerulonephritis.";
Kidney Int. 64:160-169(2003).
-!- FUNCTION: Augments natural killer cell activity in spleen cells
and stimulates interferon gamma production in T-helper type I
cells.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Beta;
IsoId=P97636-1; Sequence=Displayed;
Name=Alpha;
IsoId=P97636-2; Sequence=VSP_002659;
-!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
yield the active form. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U77776; AAC53009.1; -; mRNA.
EMBL; U77777; AAC53010.1; -; mRNA.
EMBL; AJ222813; CAA11001.1; -; mRNA.
EMBL; AY258448; AAP14669.1; -; mRNA.
EMBL; AY077842; AAL77211.1; -; mRNA.
RefSeq; NP_062038.1; NM_019165.1. [P97636-1]
UniGene; Rn.11118; -.
ProteinModelPortal; P97636; -.
SMR; P97636; -.
STRING; 10116.ENSRNOP00000013093; -.
PaxDb; P97636; -.
PRIDE; P97636; -.
GeneID; 29197; -.
KEGG; rno:29197; -.
UCSC; RGD:2889; rat. [P97636-1]
CTD; 3606; -.
RGD; 2889; Il18.
eggNOG; ENOG410J3U9; Eukaryota.
eggNOG; ENOG410ZGS8; LUCA.
HOGENOM; HOG000048723; -.
HOVERGEN; HBG000388; -.
InParanoid; P97636; -.
KO; K05482; -.
PhylomeDB; P97636; -.
TreeFam; TF336297; -.
PRO; PR:P97636; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005125; F:cytokine activity; ISO:RGD.
GO; GO:0032148; P:activation of protein kinase B activity; ISO:RGD.
GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; ISO:RGD.
GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEP:RGD.
GO; GO:0071346; P:cellular response to interferon-gamma; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0071407; P:cellular response to organic cyclic compound; ISO:RGD.
GO; GO:0071374; P:cellular response to parathyroid hormone stimulus; IEP:RGD.
GO; GO:0071375; P:cellular response to peptide hormone stimulus; IMP:RGD.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
GO; GO:0042632; P:cholesterol homeostasis; ISO:RGD.
GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IDA:RGD.
GO; GO:0048546; P:digestive tract morphogenesis; IEP:RGD.
GO; GO:0006954; P:inflammatory response; ISO:RGD.
GO; GO:0042095; P:interferon-gamma biosynthetic process; ISO:RGD.
GO; GO:0032609; P:interferon-gamma production; ISO:RGD.
GO; GO:0035655; P:interleukin-18-mediated signaling pathway; ISO:RGD.
GO; GO:0032635; P:interleukin-6 production; ISO:RGD.
GO; GO:0007611; P:learning or memory; TAS:RGD.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:RGD.
GO; GO:0030324; P:lung development; IEP:RGD.
GO; GO:0000165; P:MAPK cascade; ISO:RGD.
GO; GO:0030101; P:natural killer cell activation; ISO:RGD.
GO; GO:0042267; P:natural killer cell mediated cytotoxicity; ISO:RGD.
GO; GO:0045662; P:negative regulation of myoblast differentiation; ISO:RGD.
GO; GO:0033030; P:negative regulation of neutrophil apoptotic process; IMP:RGD.
GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:RGD.
GO; GO:0042119; P:neutrophil activation; ISO:RGD.
GO; GO:0001649; P:osteoblast differentiation; IEP:RGD.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:2000504; P:positive regulation of blood vessel remodeling; IDA:RGD.
GO; GO:0032722; P:positive regulation of chemokine production; IMP:RGD.
GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; ISO:RGD.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEP:RGD.
GO; GO:0032740; P:positive regulation of interleukin-17 production; ISO:RGD.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IDA:RGD.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISO:RGD.
GO; GO:2000256; P:positive regulation of male germ cell proliferation; IDA:RGD.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; ISO:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0042346; P:positive regulation of NF-kappaB import into nucleus; ISO:RGD.
GO; GO:0051142; P:positive regulation of NK T cell proliferation; ISO:RGD.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISO:RGD.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
GO; GO:0032930; P:positive regulation of superoxide anion generation; IMP:RGD.
GO; GO:0045630; P:positive regulation of T-helper 2 cell differentiation; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:RGD.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IMP:RGD.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:RGD.
GO; GO:0043117; P:positive regulation of vascular permeability; IMP:RGD.
GO; GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
GO; GO:0045188; P:regulation of circadian sleep/wake cycle, non-REM sleep; TAS:UniProtKB.
GO; GO:0009409; P:response to cold; IEP:RGD.
GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IMP:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0009314; P:response to radiation; IEP:RGD.
GO; GO:0030431; P:sleep; IDA:UniProtKB.
GO; GO:0035744; P:T-helper 1 cell cytokine production; ISO:RGD.
GO; GO:0042088; P:T-helper 1 type immune response; ISS:UniProtKB.
GO; GO:0070328; P:triglyceride homeostasis; ISO:RGD.
InterPro; IPR015529; IL-18.
InterPro; IPR000975; IL-1_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR45200; PTHR45200; 1.
Pfam; PF00340; IL1; 1.
PIRSF; PIRSF015162; Interleukin_18; 1.
PRINTS; PR01933; INTRLEUKIN18.
SUPFAM; SSF50353; SSF50353; 1.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Cytokine; Reference proteome;
Secreted.
PROPEP 1 36 {ECO:0000250}.
/FTId=PRO_0000015349.
CHAIN 37 194 Interleukin-18.
/FTId=PRO_0000015350.
VAR_SEQ 121 139 Missing (in isoform Alpha).
{ECO:0000303|PubMed:8999896}.
/FTId=VSP_002659.
CONFLICT 4 5 MS -> IP (in Ref. 2; CAA11001 and 4;
AAL77211). {ECO:0000305}.
CONFLICT 48 48 I -> M (in Ref. 2; CAA11001 and 4;
AAL77211). {ECO:0000305}.
SEQUENCE 194 AA; 22303 MW; E2089AD6F1798450 CRC64;
MAAMSEEGSC VNFKEMMFID NTLYLIPEDN GDLESDHFGR LHCTTAVIRS INDQVLFVDK
RNPPVFEDMP DIDRTANESQ TRLIIYMYKD SEVRGLAVTL SVKDGRMSTL SCKNKIISFE
EMNPPENIDD IKSDLIFFQK RVPGHNKMEF ESSLYEGHFL ACQKEDDAFK LVLKRKDENG
DKSVMFTLTN LHQS


Related products :

Catalog number Product name Quantity
E0064h ELISA kit Homo sapiens,Human,Iboctadekin,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,IL1F4,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
E0064h ELISA Homo sapiens,Human,Iboctadekin,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,IL1F4,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
U0064h CLIA Homo sapiens,Human,Iboctadekin,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,IL1F4,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
U0064r CLIA IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Rat,Rattus norvegicus 96T
E0064b ELISA kit Bos taurus,Bovine,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
E0064m ELISA kit IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Mouse,Mus musculus 96T
E0064r ELISA kit IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Rat,Rattus norvegicus 96T
E0064m ELISA IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Mouse,Mus musculus 96T
E0064r ELISA IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Rat,Rattus norvegicus 96T
E0064b ELISA Bos taurus,Bovine,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
U0064m CLIA IFN-gamma-inducing factor,Igif,IL-1 gamma,Il18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Mouse,Mus musculus 96T
U0064b CLIA Bos taurus,Bovine,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
E0064p ELISA IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Pig,Sus scrofa 96T
E0064p ELISA kit IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Pig,Sus scrofa 96T
U0064p CLIA IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18,Pig,Sus scrofa 96T
15-288-22501 Interleukin-18 - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin Polyclonal 0.1 mg
15-288-22501 Interleukin-18 - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin Polyclonal 0.05 mg
10-002-38034 Interleukin-18 human - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin N_A 0.05 mg
E0064c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
U0064c CLIA Canis familiaris,Canis lupus familiaris,Dog,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
E0064c ELISA Canis familiaris,Canis lupus familiaris,Dog,IFN-gamma-inducing factor,IGIF,IL-1 gamma,IL18,IL-18,Interferon gamma-inducing factor,Interleukin-1 gamma,Interleukin-18 96T
18-321-177009 INTERLEUKIN 18 (IL-18) - POLYCLONAL ANTIBODY TO MOUSE INTERLEUKIN 18 (IL-18); IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma Polyclonal 0.1 mg
10-288-22249F Interleukin-18 - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin 0.05 mg
10-288-22501 Interleukin-18 - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin 0.05 mg
10-663-45205 Interleukin-18 Rat - IL-18; Interferon-gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin N_A 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur