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Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)

 IL18_HORSE              Reviewed;         193 AA.
Q9XSQ7;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
20-JUN-2018, entry version 103.
RecName: Full=Interleukin-18;
Short=IL-18;
AltName: Full=Interferon gamma-inducing factor;
Short=IFN-gamma-inducing factor;
AltName: Full=Interleukin-1 gamma;
Short=IL-1 gamma;
Flags: Precursor;
Name=IL18; Synonyms=IGIF;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10541814; DOI=10.1007/s002510050693;
Nicolson L., Penha-Goncalves M.N., Keanie J.L., Logan N.A.,
Argyle D.J., Onions D.E.;
"Cloning and sequencing of horse interleukin-12 and interleukin-18
cDNAs.";
Immunogenetics 50:94-97(1999).
-!- FUNCTION: A proinflammatory cytokine primarily involved in
polarized T-helper 1 (Th1) cell and natural killer (NK) cell
immune responses. Upon binding to IL18R1 and IL18RAP, forms a
signaling ternary complex which activates NF-kappa-B, triggering
synthesis of inflammatory mediators. Synergizes with
IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1)
cells and natural killer (NK) cells.
{ECO:0000250|UniProtKB:Q14116}.
-!- SUBUNIT: Forms a ternary complex with ligand-binding receptor
subunit IL18R1 and signaling receptor subunit IL18RAP at the
plasma membrane. Mature IL18 first binds to IL18R1 forming a low
affinity binary complex, which then interacts with IL18RAP to form
a high affinity ternary complex that signals inside the cell.
{ECO:0000250|UniProtKB:Q14116}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q14116}.
-!- PTM: The pro-IL-18 precursor is processed by CASP1 or CASP4 to
yield the active form. {ECO:0000250}.
-!- SIMILARITY: Belongs to the IL-1 family. {ECO:0000305}.
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EMBL; Y11131; CAA72013.1; -; mRNA.
RefSeq; NP_001075981.1; NM_001082512.1.
RefSeq; XP_005611483.1; XM_005611426.2.
RefSeq; XP_005611484.1; XM_005611427.2.
UniGene; Eca.3121; -.
ProteinModelPortal; Q9XSQ7; -.
SMR; Q9XSQ7; -.
STRING; 9796.ENSECAP00000013028; -.
PaxDb; Q9XSQ7; -.
PeptideAtlas; Q9XSQ7; -.
Ensembl; ENSECAT00000016149; ENSECAP00000013028; ENSECAG00000015261.
GeneID; 100034216; -.
KEGG; ecb:100034216; -.
CTD; 3606; -.
VGNC; VGNC:19006; IL18.
eggNOG; ENOG410J3U9; Eukaryota.
eggNOG; ENOG410ZGS8; LUCA.
GeneTree; ENSGT00390000001053; -.
HOGENOM; HOG000048723; -.
HOVERGEN; HBG000388; -.
InParanoid; Q9XSQ7; -.
KO; K05482; -.
OMA; VPGHDDK; -.
OrthoDB; EOG091G0NGF; -.
TreeFam; TF336297; -.
Proteomes; UP000002281; Chromosome 7.
Bgee; ENSECAG00000015261; -.
ExpressionAtlas; Q9XSQ7; baseline.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
GO; GO:0045515; F:interleukin-18 receptor binding; ISS:UniProtKB.
GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
GO; GO:0042095; P:interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0035655; P:interleukin-18-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0032635; P:interleukin-6 production; IEA:Ensembl.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IEA:Ensembl.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISS:UniProtKB.
GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
GO; GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0032819; P:positive regulation of natural killer cell proliferation; IEA:Ensembl.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0051142; P:positive regulation of NK T cell proliferation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; ISS:UniProtKB.
GO; GO:0045630; P:positive regulation of T-helper 2 cell differentiation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0035744; P:T-helper 1 cell cytokine production; IEA:Ensembl.
GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
InterPro; IPR015529; IL-18.
InterPro; IPR000975; IL-1_fam.
InterPro; IPR008996; IL1/FGF.
PANTHER; PTHR45200; PTHR45200; 1.
Pfam; PF00340; IL1; 1.
PIRSF; PIRSF015162; Interleukin_18; 1.
PRINTS; PR01933; INTRLEUKIN18.
SUPFAM; SSF50353; SSF50353; 1.
2: Evidence at transcript level;
Complete proteome; Cytokine; Inflammatory response;
Reference proteome; Secreted.
PROPEP 1 36 {ECO:0000250}.
/FTId=PRO_0000015341.
CHAIN 37 193 Interleukin-18.
/FTId=PRO_0000015342.
SEQUENCE 193 AA; 22058 MW; 4D81535E9004ECAF CRC64;
MAAGPVEDNC ISLVEMKFID NTLYFVAEND ENLESDYFGR LEPKLSIIRN LNDQVLFINQ
GNQPVFEDMP DSDCTDNAPQ TVFIIYMYKD SLTRGLAVTI SVKCEKTSTL SCKNKIISFK
EMSPPENIND EGNDIIFFQR SVPGHDDKIQ FESSLYKGYF LACEKENDLF KLILKEKDEN
GDKSVMFTVQ NQN


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