Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)

 I18RA_MOUSE             Reviewed;         614 AA.
Q9Z2B1;
27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
10-OCT-2018, entry version 137.
RecName: Full=Interleukin-18 receptor accessory protein;
Short=IL-18 receptor accessory protein;
Short=IL-18RAcP;
AltName: Full=Accessory protein-like;
Short=AcPL;
AltName: Full=CD218 antigen-like family member B;
AltName: Full=IL-1R accessory protein-like;
Short=IL-1RAcPL;
AltName: Full=Interleukin-18 receptor accessory protein-like;
AltName: Full=Interleukin-18 receptor beta;
Short=IL-18R-beta;
Short=IL-18Rbeta;
AltName: CD_antigen=CD218b;
Flags: Precursor;
Name=Il18rap {ECO:0000312|MGI:MGI:1338888};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=9792649; DOI=10.1074/jbc.273.45.29445;
Born T.L., Thomassen E., Bird T.A., Sims J.E.;
"Cloning of a novel receptor subunit, AcPL, required for interleukin-
18 signaling.";
J. Biol. Chem. 273:29445-29450(1998).
[2]
FUNCTION.
PubMed=11046021; DOI=10.4049/jimmunol.165.9.4950;
Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R.,
Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.;
"IL-18 receptors, their role in ligand binding and function: anti-IL-
1RAcPL antibody, a potent antagonist of IL-18.";
J. Immunol. 165:4950-4956(2000).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15843532; DOI=10.4049/jimmunol.174.9.5351;
Cheung H., Chen N.-J., Cao Z., Ono N., Ohashi P.S., Yeh W.-C.;
"Accessory protein-like is essential for IL-18-mediated signaling.";
J. Immunol. 174:5351-5357(2005).
-!- FUNCTION: Within the IL18 receptor complex, does not mediate IL18-
binding, but involved in IL18-dependent signal transduction,
leading to NF-kappa-B and JNK activation (PubMed:11046021,
PubMed:15843532, PubMed:9792649). May play a role in IL18-mediated
IFNG synthesis from T-helper 1 (Th1) cells (By similarity).
{ECO:0000250|UniProtKB:O95256, ECO:0000269|PubMed:11046021,
ECO:0000269|PubMed:15843532, ECO:0000269|PubMed:9792649}.
-!- SUBUNIT: Forms a ternary complex with IL18 and IL18R1. Within this
complex, IL18R1 is involved in ligand-binding and IL18RAP in
signaling leading to NF-kappa-B and JNK activation.
{ECO:0000250|UniProtKB:O95256}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:O95256}; Single-pass type I membrane
protein {ECO:0000305}.
-!- DISRUPTION PHENOTYPE: Impaired IL-18 signaling.
{ECO:0000269|PubMed:15843532}.
-!- SIMILARITY: Belongs to the interleukin-1 receptor family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF077347; AAC72197.1; -; mRNA.
CCDS; CCDS14912.1; -.
RefSeq; NP_034683.1; NM_010553.4.
UniGene; Mm.20466; -.
UniGene; Mm.392521; -.
ProteinModelPortal; Q9Z2B1; -.
SMR; Q9Z2B1; -.
STRING; 10090.ENSMUSP00000027237; -.
iPTMnet; Q9Z2B1; -.
PhosphoSitePlus; Q9Z2B1; -.
EPD; Q9Z2B1; -.
PaxDb; Q9Z2B1; -.
PRIDE; Q9Z2B1; -.
Ensembl; ENSMUST00000027237; ENSMUSP00000027237; ENSMUSG00000026068.
GeneID; 16174; -.
KEGG; mmu:16174; -.
UCSC; uc007auk.2; mouse.
CTD; 8807; -.
MGI; MGI:1338888; Il18rap.
eggNOG; ENOG410IGUG; Eukaryota.
eggNOG; ENOG410Y9SN; LUCA.
GeneTree; ENSGT00760000119071; -.
HOGENOM; HOG000060101; -.
HOVERGEN; HBG081778; -.
InParanoid; Q9Z2B1; -.
KO; K05174; -.
OMA; YVCDYTQ; -.
OrthoDB; EOG091G0GXW; -.
PhylomeDB; Q9Z2B1; -.
TreeFam; TF325519; -.
Reactome; R-MMU-9012546; Interleukin-18 signaling.
PRO; PR:Q9Z2B1; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026068; Expressed in 43 organ(s), highest expression level in blood.
CleanEx; MM_IL18RAP; -.
ExpressionAtlas; Q9Z2B1; baseline and differential.
Genevisible; Q9Z2B1; MM.
GO; GO:0045092; C:interleukin-18 receptor complex; ISO:MGI.
GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
GO; GO:0042008; F:interleukin-18 receptor activity; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; IMP:MGI.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0071351; P:cellular response to interleukin-18; IMP:MGI.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0032609; P:interferon-gamma production; IMP:MGI.
GO; GO:0035655; P:interleukin-18-mediated signaling pathway; IMP:MGI.
GO; GO:0032635; P:interleukin-6 production; IMP:MGI.
GO; GO:0042119; P:neutrophil activation; IMP:MGI.
GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IMP:MGI.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
GO; GO:0035744; P:T-helper 1 cell cytokine production; IMP:MGI.
Gene3D; 2.60.40.10; -; 2.
Gene3D; 3.40.50.10140; -; 1.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR015621; IL-1_rcpt_fam.
InterPro; IPR004074; IL-1_rcpt_I/II-typ.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR000157; TIR_dom.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR11890; PTHR11890; 1.
Pfam; PF00047; ig; 1.
Pfam; PF01582; TIR; 1.
PRINTS; PR01536; INTRLKN1R12F.
SMART; SM00409; IG; 2.
SMART; SM00255; TIR; 1.
SUPFAM; SSF48726; SSF48726; 2.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS50835; IG_LIKE; 2.
PROSITE; PS50104; TIR; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Inflammatory response; Membrane; Receptor;
Reference proteome; Repeat; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 614 Interleukin-18 receptor accessory
protein.
/FTId=PRO_0000042186.
TOPO_DOM 20 356 Extracellular. {ECO:0000255}.
TRANSMEM 357 377 Helical. {ECO:0000255}.
TOPO_DOM 378 614 Cytoplasmic. {ECO:0000255}.
DOMAIN 148 234 Ig-like C2-type 1.
DOMAIN 250 352 Ig-like C2-type 2.
DOMAIN 405 561 TIR. {ECO:0000255|PROSITE-
ProRule:PRU00204}.
CARBOHYD 21 21 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 151 151 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 227 227 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 344 344 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 46 126 {ECO:0000250|UniProtKB:O95256}.
DISULFID 154 179 {ECO:0000250|UniProtKB:O95256}.
DISULFID 174 220 {ECO:0000250|UniProtKB:O95256}.
DISULFID 179 220 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 272 336 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 614 AA; 70094 MW; B71D005E4FA99BA1 CRC64;
MLCLGWVFLW FVAGEKTTGF NHSACATKKL LWTYSARGAE NFVLFCDLQE LQEQKFSHAS
QLSPTQSPAH KPCSGSQKDL SDVQWYMQPR SGSPLEEISR NSPHMQSEGM LHILAPQTNS
IWSYICRPRI RSPQDMACCI KTVLEVKPQR NVSCGNTAQD EQVLLLGSTG SIHCPSLSCQ
SDVQSPEMTW YKDGRLLPEH KKNPIEMADI YVFNQGLYVC DYTQSDNVSS WTVRAVVKVR
TIGKDINVKP EILDPITDTL DVELGKPLTL PCRVQFGFQR LSKPVIKWYV KESTQEWEMS
VFEEKRIQST FKNEVIERTI FLREVTQRDL SRKFVCFAQN SIGNTTRTIR LRKKEEVVFV
YILLGTALML VGVLVAAAFL YWYWIEVVLL CRTYKNKDET LGDKKEFDAF VSYSNWSSPE
TDAVGSLSEE HLALNLFPEV LEDTYGYRLC LLDRDVTPGG VYADDIVSII KKSRRGIFIL
SPSYLNGPRV FELQAAVNLA LVDQTLKLIL IKFCSFQEPE SLPYLVKKAL RVLPTVTWKG
LKSVHASSRF WTQIRYHMPV KNSNRFMFNG LRIFLKGFSP EKDLVTQKPL EGMPKSGNDH
GAQNLLLYSD QKRC


Related products :

Catalog number Product name Quantity
26-207 IL1RAPL2 is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 0.05 mg
C477 Interleukin-1 Receptor Accessory Protein IL-1RAcP lmg
CC35 Interleukin-18 receptor accessory protein IL18RAP (C-Fc-His tag) lmg
E9331h Human Interleukin 18 Receptor Accessory Protein EL 96T
CB73 Interleukin-18 receptor accessory protein IL18RAP (C-His tag) lmg
IRPL1_RAT Rat ELISA Kit FOR Interleukin-1 receptor accessory protein-like 1 96T
CC35 Interleukin-18 receptor accessory protein IL18RAP (C-Fc-His tag) 500
CB73 Interleukin-18 receptor accessory protein IL18RAP (C-His tag) 500
C477 Interleukin-1 Receptor Accessory Protein IL-1RAcP 500
YHB1697Hu Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 48T
UB-E04303 Human Interleukin 1 Receptor Accessory Protein Like Protein 2(IL1RAPL2)ELISA Kit 96T
201-12-2765 Human Interleukin 1 Receptor Accessory Protein Like Protein 2(IL1RAPL2)ELISA Kit 96T
27759 Mouse Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 10ng/ml-0.156ng/ml <0.05ng/ml
E12531041 Mouse Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 1
201-12-2765 Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 48T
UT-E04303 Human Interleukin 1 Receptor Accessory Protein Like Protein 2(IL1RAPL2)ELISA Kit 96T
QY-E04303 Human Interleukin 1 Receptor Accessory Protein Like Protein 2(IL1RAPL2)ELISA Kit 96T
E2764Hu Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 96T
20329 Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 96T
33256 Rabbit Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 10ng/ml-0.156ng/ml <0.05ng/ml
E13750996 Rabbit Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 1
E13650999 Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2) ELISA Kit 1
IL1RAP-1638H Protein: Recombinant Human Interleukin 1 Receptor Accessory Protein-Like 1 100
E2764Hu Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 48T
YHB1697Hu Human Interleukin 1 Receptor Accessory Protein Like Protein 2 (IL1RAPL2)ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur