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Interleukin-22 receptor subunit alpha-1 (IL-22 receptor subunit alpha-1) (IL-22R-alpha-1) (IL-22RA1) (Cytokine receptor class-II member 9) (Cytokine receptor family 2 member 9) (CRF2-9) (ZcytoR11)

 I22R1_HUMAN             Reviewed;         574 AA.
Q8N6P7; A8K839; B2R9Y9; Q9HB22;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
12-SEP-2018, entry version 145.
RecName: Full=Interleukin-22 receptor subunit alpha-1;
Short=IL-22 receptor subunit alpha-1;
Short=IL-22R-alpha-1;
Short=IL-22RA1;
AltName: Full=Cytokine receptor class-II member 9;
AltName: Full=Cytokine receptor family 2 member 9;
Short=CRF2-9;
AltName: Full=ZcytoR11;
Flags: Precursor;
Name=IL22RA1; Synonyms=IL22R;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-518.
PubMed=10875937; DOI=10.1074/jbc.M005304200;
Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J.,
Wood W.I., Goddard A.D., Gurney A.L.;
"Interleukin (IL)-22, a novel human cytokine that signals through the
interferon receptor-related proteins CRF2-4 and IL-22R.";
J. Biol. Chem. 275:31335-31339(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-518.
TISSUE=Esophagus, and Liver;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Adrenal cortex;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
FUNCTION, AND SUBUNIT.
PubMed=11035029; DOI=10.1074/jbc.M007837200;
Kotenko S.V., Izotova L.S., Mirochnitchenko O.V., Esterova E.,
Dickensheets H., Donnelly R.P., Pestka S.;
"Identification of the functional interleukin-22 (IL-22) receptor
complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the
IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-
TIF) receptor complexes.";
J. Biol. Chem. 276:2725-2732(2001).
[7]
FUNCTION.
PubMed=11564763; DOI=10.4049/jimmunol.167.7.3545;
Dumoutier L., Leemans C., Lejeune D., Kotenko S.V., Renauld J.-C.;
"STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor
complexes of two types.";
J. Immunol. 167:3545-3549(2001).
[8]
TISSUE SPECIFICITY.
PubMed=12407026; DOI=10.1093/intimm/dxf096;
Lecart S., Morel F., Noraz N., Pene J., Garcia M., Boniface K.,
Lecron J.-C., Yssel H.;
"IL-22, in contrast to IL-10, does not induce Ig production, due to
absence of a functional IL-22 receptor on activated human B cells.";
Int. Immunol. 14:1351-1356(2002).
[9]
FUNCTION.
PubMed=11706020; DOI=10.1074/jbc.M106043200;
Wang M., Tan Z., Zhang R., Kotenko S.V., Liang P.;
"Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric
receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2.";
J. Biol. Chem. 277:7341-7347(2002).
[10]
FUNCTION.
PubMed=12351624; DOI=10.1074/jbc.M205114200;
Parrish-Novak J., Xu W., Brender T., Yao L., Jones C., West J.,
Brandt C., Jelinek L., Madden K., McKernan P.A., Foster D.C.,
Jaspers S., Chandrasekher Y.A.;
"Interleukins 19, 20, and 24 signal through two distinct receptor
complexes. Differences in receptor-ligand interactions mediate unique
biological functions.";
J. Biol. Chem. 277:47517-47523(2002).
[11]
FUNCTION.
PubMed=12941841;
Ramesh R., Mhashilkar A.M., Tanaka F., Saito Y., Branch C.D.,
Sieger K., Mumm J.B., Stewart A.L., Boquoi A., Dumoutier L.,
Grimm E.A., Renauld J.-C., Kotenko S., Chada S.;
"Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a
novel ligand that regulates angiogenesis via the IL-22 receptor.";
Cancer Res. 63:5105-5113(2003).
[12]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=15308104; DOI=10.1016/j.immuni.2004.07.007;
Wolk K., Kunz S., Witte E., Friedrich M., Asadullah K., Sabat R.;
"IL-22 increases the innate immunity of tissues.";
Immunity 21:241-254(2004).
[13]
SUBUNIT.
PubMed=15120653; DOI=10.1016/j.intimp.2004.01.010;
Li J., Tomkinson K.N., Tan X.-Y., Wu P., Yan G., Spaulding V.,
Deng B., Annis-Freeman B., Heveron K., Zollner R., De Zutter G.,
Wright J.F., Crawford T.K., Liu W., Jacobs K.A., Wolfman N.M.,
Ling V., Pittman D.D., Veldman G.M., Fouser L.A.;
"Temporal associations between interleukin 22 and the extracellular
domains of IL-22R and IL-10R2.";
Int. Immunopharmacol. 4:693-708(2004).
[14]
FUNCTION.
PubMed=17204547; DOI=10.1152/ajpgi.00239.2006;
Brand S., Dambacher J., Beigel F., Zitzmann K., Heeg M.H.J.,
Weiss T.S., Pruefer T., Olszak T., Steib C.J., Storr M., Goeke B.,
Diepolder H., Bilzer M., Thasler W.E., Auernhammer C.J.;
"IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3
overexpression in vitro.";
Am. J. Physiol. 292:G1019-G1028(2007).
[15]
TISSUE SPECIFICITY.
PubMed=17900301; DOI=10.1111/j.1365-2249.2007.03511.x;
Boniface K., Guignouard E., Pedretti N., Garcia M., Delwail A.,
Bernard F.-X., Nau F., Guillet G., Dagregorio G., Yssel H.,
Lecron J.-C., Morel F.;
"A role for T cell-derived interleukin 22 in psoriatic skin
inflammation.";
Clin. Exp. Immunol. 150:407-415(2007).
[16]
ASSOCIATION WITH CHRONIC RHINOSINUSITIS.
PubMed=17906500; DOI=10.1097/MLG.0b013e31811edd4f;
Ramanathan M. Jr., Spannhake E.W., Lane A.P.;
"Chronic rhinosinusitis with nasal polyps is associated with decreased
expression of mucosal interleukin 22 receptor.";
Laryngoscope 117:1839-1843(2007).
[17]
TISSUE SPECIFICITY.
PubMed=17828272; DOI=10.1038/nm1651;
Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R.,
Bernard M., Giuliani F., Arbour N., Becher B., Prat A.;
"Human TH17 lymphocytes promote blood-brain barrier disruption and
central nervous system inflammation.";
Nat. Med. 13:1173-1175(2007).
[18]
TISSUE SPECIFICITY.
PubMed=18061474; DOI=10.1016/j.cyto.2007.10.004;
Kragstrup T.W., Otkjaer K., Holm C., Jorgensen A., Hokland M.,
Iversen L., Deleuran B.;
"The expression of IL-20 and IL-24 and their shared receptors are
increased in rheumatoid arthritis and spondyloarthropathy.";
Cytokine 41:16-23(2008).
[19]
X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 18-228 IN COMPLEX WITH IL22,
MUTAGENESIS OF LYS-58 AND TYR-60, AND DISULFIDE BONDS.
PubMed=18675809; DOI=10.1016/j.febslet.2008.07.046;
Bleicher L., de Moura P.R., Watanabe L., Colau D., Dumoutier L.,
Renauld J.-C., Polikarpov I.;
"Crystal structure of the IL-22/IL-22R1 complex and its implications
for the IL-22 signaling mechanism.";
FEBS Lett. 582:2985-2992(2008).
-!- FUNCTION: Component of the receptor for IL20, IL22 and IL24.
Component of IL22 receptor formed by IL22RA1 and IL10RB enabling
IL22 signaling via JAK/STAT pathways. IL22 also induces activation
of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the
receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also
signaling through STATs activation. Mediates IL24 antiangiogenic
activity as well as IL24 inhibitory effect on endothelial cell
tube formation and differentiation. {ECO:0000269|PubMed:11035029,
ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020,
ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841,
ECO:0000269|PubMed:17204547}.
-!- SUBUNIT: Heterodimer with IL10RB and with IL20RB. IL22 binding to
heterodimer is greater than binding to IL22RA1 alone.
{ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:15120653,
ECO:0000269|PubMed:18675809}.
-!- INTERACTION:
Q08334:IL10RB; NbExp=5; IntAct=EBI-3940749, EBI-11175900;
Q9GZX6:IL22; NbExp=9; IntAct=EBI-3940749, EBI-8040250;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- TISSUE SPECIFICITY: Expressed in colon, liver, lung, pancreas and
kidney. No expression in immune cells such as monocytes, T-cells,
and NK-cells. Expressed in keratinocytes of normal skin as well as
in psoriatic skin lesion. Detected in normal blood brain barrier
endothelial cells as well as in multiple sclerosis lesions;
Strongly expressed on central nervous system vessels within
infiltrated multiple sclerosis lesions. Overexpressed in synovial
fluid cells from rheumatoid arthritis and spondyloarthropathy
patients. {ECO:0000269|PubMed:12407026,
ECO:0000269|PubMed:15308104, ECO:0000269|PubMed:17828272,
ECO:0000269|PubMed:17900301, ECO:0000269|PubMed:18061474}.
-!- INDUCTION: By IFNG/IFN-gamma in keratinocytes.
{ECO:0000269|PubMed:15308104}.
-!- MISCELLANEOUS: Failure of medical and surgical therapy in Chronic
rhinosinusitis with nasal polyps is associated with decreased
expression of IL22RA1.
-!- SIMILARITY: Belongs to the type II cytokine receptor family.
{ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/IL22RA1ID44568ch1p36.html";
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EMBL; AF286095; AAG22073.1; -; mRNA.
EMBL; AK292204; BAF84893.1; -; mRNA.
EMBL; AK313971; BAG36686.1; -; mRNA.
EMBL; AL590683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL591178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471134; EAW95111.1; -; Genomic_DNA.
EMBL; BC029273; AAH29273.1; -; mRNA.
CCDS; CCDS247.1; -.
RefSeq; NP_067081.2; NM_021258.3.
UniGene; Hs.110915; -.
PDB; 3DGC; X-ray; 2.50 A; R/S=17-226.
PDB; 3DLQ; X-ray; 1.90 A; R=18-228.
PDBsum; 3DGC; -.
PDBsum; 3DLQ; -.
ProteinModelPortal; Q8N6P7; -.
SMR; Q8N6P7; -.
BioGrid; 121855; 26.
DIP; DIP-42031N; -.
IntAct; Q8N6P7; 6.
MINT; Q8N6P7; -.
STRING; 9606.ENSP00000270800; -.
iPTMnet; Q8N6P7; -.
PhosphoSitePlus; Q8N6P7; -.
BioMuta; IL22RA1; -.
DMDM; 74751067; -.
PaxDb; Q8N6P7; -.
PeptideAtlas; Q8N6P7; -.
PRIDE; Q8N6P7; -.
ProteomicsDB; 72209; -.
DNASU; 58985; -.
Ensembl; ENST00000270800; ENSP00000270800; ENSG00000142677.
GeneID; 58985; -.
KEGG; hsa:58985; -.
UCSC; uc001biq.3; human.
CTD; 58985; -.
DisGeNET; 58985; -.
EuPathDB; HostDB:ENSG00000142677.3; -.
GeneCards; IL22RA1; -.
HGNC; HGNC:13700; IL22RA1.
MIM; 605457; gene.
neXtProt; NX_Q8N6P7; -.
OpenTargets; ENSG00000142677; -.
PharmGKB; PA29823; -.
eggNOG; ENOG410IF2U; Eukaryota.
eggNOG; ENOG4111CQU; LUCA.
GeneTree; ENSGT00530000063352; -.
HOGENOM; HOG000060223; -.
HOVERGEN; HBG104189; -.
InParanoid; Q8N6P7; -.
KO; K05138; -.
OMA; SVQIEGH; -.
OrthoDB; EOG091G068P; -.
PhylomeDB; Q8N6P7; -.
TreeFam; TF334107; -.
Reactome; R-HSA-8854691; Interleukin-20 family signaling.
SignaLink; Q8N6P7; -.
SIGNOR; Q8N6P7; -.
ChiTaRS; IL22RA1; human.
EvolutionaryTrace; Q8N6P7; -.
GenomeRNAi; 58985; -.
PRO; PR:Q8N6P7; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000142677; Expressed in 103 organ(s), highest expression level in body of pancreas.
CleanEx; HS_IL22RA1; -.
Genevisible; Q8N6P7; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0004904; F:interferon receptor activity; TAS:UniProtKB.
GO; GO:0042015; F:interleukin-20 binding; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:Ensembl.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR015373; Interferon/interleukin_rcp_dom.
Pfam; PF09294; Interfer-bind; 1.
Pfam; PF01108; Tissue_fac; 1.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 15 {ECO:0000255}.
CHAIN 16 574 Interleukin-22 receptor subunit alpha-1.
/FTId=PRO_0000324320.
TOPO_DOM 16 228 Extracellular. {ECO:0000255}.
TRANSMEM 229 249 Helical. {ECO:0000255}.
TOPO_DOM 250 574 Cytoplasmic. {ECO:0000255}.
DOMAIN 17 124 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 141 221 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
CARBOHYD 80 80 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 172 172 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 71 79 {ECO:0000269|PubMed:18675809}.
DISULFID 128 217 {ECO:0000269|PubMed:18675809}.
VARIANT 130 130 S -> P (in dbSNP:rs34900099).
/FTId=VAR_039699.
VARIANT 205 205 V -> I (in dbSNP:rs16829204).
/FTId=VAR_039700.
VARIANT 209 209 A -> S (in dbSNP:rs34379702).
/FTId=VAR_039701.
VARIANT 222 222 L -> P (in dbSNP:rs34782294).
/FTId=VAR_039702.
VARIANT 407 407 M -> V (in dbSNP:rs35401673).
/FTId=VAR_039703.
VARIANT 518 518 R -> G (in dbSNP:rs3795299).
{ECO:0000269|PubMed:10875937,
ECO:0000269|PubMed:14702039}.
/FTId=VAR_039704.
MUTAGEN 58 58 K->A: Strongly reduced response to IL22.
{ECO:0000269|PubMed:18675809}.
MUTAGEN 60 60 Y->A,R: Loss of response to IL22.
{ECO:0000269|PubMed:18675809}.
CONFLICT 117 117 Q -> R (in Ref. 2; BAF84893).
{ECO:0000305}.
HELIX 21 23 {ECO:0000244|PDB:3DLQ}.
STRAND 25 33 {ECO:0000244|PDB:3DLQ}.
STRAND 36 43 {ECO:0000244|PDB:3DLQ}.
STRAND 49 59 {ECO:0000244|PDB:3DLQ}.
STRAND 72 80 {ECO:0000244|PDB:3DLQ}.
HELIX 83 85 {ECO:0000244|PDB:3DLQ}.
STRAND 92 100 {ECO:0000244|PDB:3DLQ}.
STRAND 105 109 {ECO:0000244|PDB:3DLQ}.
HELIX 115 118 {ECO:0000244|PDB:3DLQ}.
STRAND 126 130 {ECO:0000244|PDB:3DLQ}.
STRAND 132 139 {ECO:0000244|PDB:3DLQ}.
STRAND 143 147 {ECO:0000244|PDB:3DGC}.
STRAND 153 155 {ECO:0000244|PDB:3DGC}.
HELIX 156 159 {ECO:0000244|PDB:3DLQ}.
STRAND 164 170 {ECO:0000244|PDB:3DLQ}.
STRAND 177 190 {ECO:0000244|PDB:3DLQ}.
STRAND 196 205 {ECO:0000244|PDB:3DLQ}.
HELIX 206 208 {ECO:0000244|PDB:3DLQ}.
STRAND 215 220 {ECO:0000244|PDB:3DLQ}.
SEQUENCE 574 AA; 63077 MW; D46CC71D496F3420 CRC64;
MRTLLTILTV GSLAAHAPED PSDLLQHVKF QSSNFENILT WDSGPEGTPD TVYSIEYKTY
GERDWVAKKG CQRITRKSCN LTVETGNLTE LYYARVTAVS AGGRSATKMT DRFSSLQHTT
LKPPDVTCIS KVRSIQMIVH PTPTPIRAGD GHRLTLEDIF HDLFYHLELQ VNRTYQMHLG
GKQREYEFFG LTPDTEFLGT IMICVPTWAK ESAPYMCRVK TLPDRTWTYS FSGAFLFSMG
FLVAVLCYLS YRYVTKPPAP PNSLNVQRVL TFQPLRFIQE HVLIPVFDLS GPSSLAQPVQ
YSQIRVSGPR EPAGAPQRHS LSEITYLGQP DISILQPSNV PPPQILSPLS YAPNAAPEVG
PPSYAPQVTP EAQFPFYAPQ AISKVQPSSY APQATPDSWP PSYGVCMEGS GKDSPTGTLS
SPKHLRPKGQ LQKEPPAGSC MLGGLSLQEV TSLAMEESQE AKSLHQPLGI CTDRTSDPNV
LHSGEEGTPQ YLKGQLPLLS SVQIEGHPMS LPLQPPSRPC SPSDQGPSPW GLLESLVCPK
DEAKSPAPET SDLEQPTELD SLFRGLALTV QWES


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