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Interleukin-26 (IL-26) (Protein AK155)

 IL26_HUMAN              Reviewed;         171 AA.
Q9NPH9;
16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
12-SEP-2018, entry version 145.
RecName: Full=Interleukin-26;
Short=IL-26;
AltName: Full=Protein AK155;
Flags: Precursor;
Name=IL26; Synonyms=AK155;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=10729163; DOI=10.1128/JVI.74.8.3881-3887.2000;
Knappe A., Hor S., Wittmann S., Fickenscher H.;
"Induction of a novel cellular homolog of interleukin-10, AK155, by
transformation of T lymphocytes with herpesvirus saimiri.";
J. Virol. 74:3881-3887(2000).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION.
PubMed=15178681; DOI=10.1074/jbc.M405000200;
Hor S., Pirzer H., Dumoutier L., Bauer F., Wittmann S., Sticht H.,
Renauld J.C., de Waal Malefyt R., Fickenscher H.;
"The T-cell lymphokine interleukin-26 targets epithelial cells through
the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains.";
J. Biol. Chem. 279:33343-33351(2004).
[5]
FUNCTION, AND RECEPTOR-BINDING.
PubMed=14764663; DOI=10.4049/jimmunol.172.4.2006;
Sheikh F., Baurin V.V., Lewis-Antes A., Shah N.K., Smirnov S.V.,
Anantha S., Dickensheets H., Dumoutier L., Renauld J.-C., Zdanov A.,
Donnelly R.P., Kotenko S.V.;
"IL-26 signals through a novel receptor complex composed of IL-20
receptor 1 and IL-10 receptor 2.";
J. Immunol. 172:2006-2010(2004).
[6]
FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=18483078; DOI=10.1136/gut.2007.130112;
Dambacher J., Beigel F., Zitzmann K., De Toni E.N., Goke B.,
Diepolder H.M., Auernhammer C.J., Brand S.;
"The role of the novel Th17 cytokine IL-26 in intestinal
inflammation.";
Gut 58:1207-1217(2009).
-!- FUNCTION: May play a role in local mechanisms of mucosal immunity
and seems to have a proinflammatory function. May play a role in
inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3
(ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and
IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1.
Decreases proliferation of intestinal epithelial cells. Is
inhibited by heparin. {ECO:0000269|PubMed:14764663,
ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18483078}.
-!- TISSUE SPECIFICITY: Expressed in HVS transformed T-cells but not
other T-cell lines or primary stimulated T-cells. Expressed in
colonic T-cells including Th17 inflammatory T-cells; the
expression is significantly increased in serum of patients with
Crohn's disease (at protein level). {ECO:0000269|PubMed:18483078}.
-!- INDUCTION: By Herpesvirus saimiri infection.
-!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-26 entry;
URL="https://en.wikipedia.org/wiki/Interleukin_26";
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il26/";
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EMBL; AJ251550; CAB77049.1; -; Genomic_DNA.
EMBL; AJ251551; CAB77049.1; JOINED; Genomic_DNA.
EMBL; AJ251549; CAB76942.1; -; mRNA.
EMBL; AY509906; AAR87776.1; -; Genomic_DNA.
EMBL; BC066270; AAH66270.1; -; mRNA.
EMBL; BC066271; AAH66271.1; -; mRNA.
CCDS; CCDS8981.1; -.
RefSeq; NP_060872.1; NM_018402.1.
UniGene; Hs.272350; -.
ProteinModelPortal; Q9NPH9; -.
SMR; Q9NPH9; -.
BioGrid; 120913; 1.
STRING; 9606.ENSP00000229134; -.
iPTMnet; Q9NPH9; -.
PhosphoSitePlus; Q9NPH9; -.
BioMuta; IL26; -.
DMDM; 17366984; -.
PaxDb; Q9NPH9; -.
PeptideAtlas; Q9NPH9; -.
PRIDE; Q9NPH9; -.
ProteomicsDB; 82013; -.
DNASU; 55801; -.
Ensembl; ENST00000229134; ENSP00000229134; ENSG00000111536.
GeneID; 55801; -.
KEGG; hsa:55801; -.
UCSC; uc001stx.2; human.
CTD; 55801; -.
DisGeNET; 55801; -.
EuPathDB; HostDB:ENSG00000111536.4; -.
GeneCards; IL26; -.
HGNC; HGNC:17119; IL26.
MIM; 605679; gene.
neXtProt; NX_Q9NPH9; -.
OpenTargets; ENSG00000111536; -.
PharmGKB; PA29826; -.
eggNOG; ENOG410IW3K; Eukaryota.
eggNOG; ENOG410ZCBR; LUCA.
GeneTree; ENSGT00510000049242; -.
HOGENOM; HOG000113042; -.
InParanoid; Q9NPH9; -.
KO; K05446; -.
OMA; WIKKFLE; -.
OrthoDB; EOG091G0OVX; -.
PhylomeDB; Q9NPH9; -.
TreeFam; TF333253; -.
Reactome; R-HSA-8854691; Interleukin-20 family signaling.
SignaLink; Q9NPH9; -.
SIGNOR; Q9NPH9; -.
GeneWiki; Interleukin_26; -.
GenomeRNAi; 55801; -.
PRO; PR:Q9NPH9; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000111536; Expressed in 27 organ(s), highest expression level in amniotic fluid.
CleanEx; HS_IL26; -.
Genevisible; Q9NPH9; HS.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005125; F:cytokine activity; IDA:UniProtKB.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IDA:UniProtKB.
GO; GO:0050715; P:positive regulation of cytokine secretion; IDA:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.
GO; GO:0046427; P:positive regulation of JAK-STAT cascade; IDA:UniProtKB.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IDA:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR020443; IL-10/19/20/22/24/26_fam.
InterPro; IPR020423; IL-10_CS.
Pfam; PF00726; IL10; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00520; INTERLEUKIN_10; 1.
1: Evidence at protein level;
Complete proteome; Cytokine; Reference proteome; Secreted; Signal.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 171 Interleukin-26.
/FTId=PRO_0000015387.
SEQUENCE 171 AA; 19843 MW; 31F6261E42B6ACC0 CRC64;
MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA WLKATIPEDR
IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ GCKKIRFVED FHSLRQKLSH
CISCASSARE MKSITRMKRI FYRIGNKGIY KAISELDILL SWIKKLLESS Q


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