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Interleukin-27 subunit beta (IL-27 subunit beta) (IL-27B) (Epstein-Barr virus-induced gene 3 protein) (EBV-induced gene 3 protein)

 IL27B_HUMAN             Reviewed;         229 AA.
Q14213; A0N0N2; O75269;
24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
24-MAY-2004, sequence version 2.
18-JUL-2018, entry version 156.
RecName: Full=Interleukin-27 subunit beta;
Short=IL-27 subunit beta;
Short=IL-27B;
AltName: Full=Epstein-Barr virus-induced gene 3 protein;
Short=EBV-induced gene 3 protein;
Flags: Precursor;
Name=EBI3; Synonyms=IL27B;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, GLYCOSYLATION, AND INTERACTION
WITH SQSTM1.
TISSUE=B-cell;
PubMed=8551575;
Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C.,
Kieff E., Birkenbach M.;
"A novel interleukin-12 p40-related protein induced by latent Epstein-
Barr virus infection in B lymphocytes.";
J. Virol. 70:1143-1153(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-201.
Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
Nickerson D.A.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-201.
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SUBUNIT, AND INTERACTION WITH IL12A.
PubMed=9342359; DOI=10.1073/pnas.94.22.12041;
Devergne O., Birkenbach M., Kieff E.;
"Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin
12 form a novel heterodimeric hematopoietin.";
Proc. Natl. Acad. Sci. U.S.A. 94:12041-12046(1997).
[7]
FUNCTION, AND SUBUNIT.
PubMed=12121660; DOI=10.1016/S1074-7613(02)00324-2;
Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J.,
Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M.,
Mattson J.D., Wagner J.L., To W., Zurawski S., McClanahan T.K.,
Gorman D.M., Bazan J.F., de Waal Malefyt R., Rennick D.,
Kastelein R.A.;
"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein,
induces proliferation of naive CD4(+) T cells.";
Immunity 16:779-790(2002).
[8]
REVIEW ON IL-27.
PubMed=17294231; DOI=10.1007/s00109-007-0164-7;
Batten M., Ghilardi N.;
"The biology and therapeutic potential of interleukin 27.";
J. Mol. Med. 85:661-672(2007).
-!- FUNCTION: Associates with IL27 to form the IL-27 interleukin, a
heterodimeric cytokine which functions in innate immunity. IL-27
has pro- and anti-inflammatory properties, that can regulate T-
helper cell development, suppress T-cell proliferation, stimulate
cytotoxic T-cell activity, induce isotype switching in B-cells,
and that has diverse effects on innate immune cells. Among its
target cells are CD4 T-helper cells which can differentiate in
type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17
producing helper T-cells (TH17). It drives rapid clonal expansion
of naive but not memory CD4 T-cells. It also strongly synergizes
with IL-12 to trigger interferon-gamma/IFN-gamma production of
naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR.
Another important role of IL-27 is its antitumor activity as well
as its antiangiogenic activity with activation of production of
antiangiogenic chemokines. {ECO:0000269|PubMed:12121660}.
-!- SUBUNIT: Heterodimer with IL27/IL27A; not disulfide-linked. This
heterodimer is known as interleukin IL-27. EBI3 is also a
component of the IL-12 heterodimer. Interacts with SQSTM1.
Heterodimer with IL12A; this heterodimer is known as interleukin
IL-35. {ECO:0000269|PubMed:12121660, ECO:0000269|PubMed:8551575,
ECO:0000269|PubMed:9342359}.
-!- INTERACTION:
Q8NEV9:IL27; NbExp=2; IntAct=EBI-742959, EBI-15887997;
-!- SUBCELLULAR LOCATION: Secreted.
-!- INDUCTION: By Epstein-Barr virus (EBV).
{ECO:0000269|PubMed:8551575}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=Wikipedia; Note=Interleukin-27 entry;
URL="https://en.wikipedia.org/wiki/Interleukin_27";
-----------------------------------------------------------------------
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EMBL; L08187; AAA93193.1; -; mRNA.
EMBL; EF064740; ABK41923.1; -; Genomic_DNA.
EMBL; AC005578; AAC33488.1; -; Genomic_DNA.
EMBL; CH471139; EAW69245.1; -; Genomic_DNA.
EMBL; BC015364; AAH15364.1; -; mRNA.
EMBL; BC046112; AAH46112.1; -; mRNA.
CCDS; CCDS12123.1; -.
RefSeq; NP_005746.2; NM_005755.2.
RefSeq; XP_011525921.1; XM_011527619.2.
UniGene; Hs.501452; -.
ProteinModelPortal; Q14213; -.
BioGrid; 115450; 11.
DIP; DIP-57556N; -.
IntAct; Q14213; 8.
MINT; Q14213; -.
STRING; 9606.ENSP00000221847; -.
BioMuta; EBI3; -.
DMDM; 47605806; -.
MaxQB; Q14213; -.
PaxDb; Q14213; -.
PeptideAtlas; Q14213; -.
PRIDE; Q14213; -.
ProteomicsDB; 59933; -.
DNASU; 10148; -.
Ensembl; ENST00000221847; ENSP00000221847; ENSG00000105246.
GeneID; 10148; -.
KEGG; hsa:10148; -.
UCSC; uc002lzu.4; human.
CTD; 10148; -.
DisGeNET; 10148; -.
EuPathDB; HostDB:ENSG00000105246.5; -.
GeneCards; EBI3; -.
HGNC; HGNC:3129; EBI3.
HPA; HPA046635; -.
MIM; 605816; gene.
neXtProt; NX_Q14213; -.
OpenTargets; ENSG00000105246; -.
PharmGKB; PA27584; -.
eggNOG; ENOG410IX61; Eukaryota.
eggNOG; ENOG4111KU8; LUCA.
GeneTree; ENSGT00530000063103; -.
HOGENOM; HOG000294168; -.
HOVERGEN; HBG052107; -.
InParanoid; Q14213; -.
OMA; FIATYRL; -.
OrthoDB; EOG091G0P18; -.
PhylomeDB; Q14213; -.
TreeFam; TF331210; -.
Reactome; R-HSA-8984722; Interleukin-35 Signalling.
Reactome; R-HSA-9020956; Interleukin-27 signaling.
ChiTaRS; EBI3; human.
GeneWiki; EBI3; -.
GenomeRNAi; 10148; -.
PRO; PR:Q14213; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000105246; -.
CleanEx; HS_EBI3; -.
Genevisible; Q14213; HS.
GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:ProtInc.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0004896; F:cytokine receptor activity; IPI:UniProtKB.
GO; GO:0045523; F:interleukin-27 receptor binding; IEA:Ensembl.
GO; GO:0006959; P:humoral immune response; TAS:ProtInc.
GO; GO:0070106; P:interleukin-27-mediated signaling pathway; TAS:Reactome.
GO; GO:0070757; P:interleukin-35-mediated signaling pathway; TAS:Reactome.
GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; TAS:UniProtKB.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; TAS:UniProtKB.
GO; GO:0042098; P:T cell proliferation; IEA:Ensembl.
GO; GO:0042088; P:T-helper 1 type immune response; TAS:UniProtKB.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR013783; Ig-like_fold.
Pfam; PF00041; fn3; 1.
SMART; SM00060; FN3; 2.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
1: Evidence at protein level;
Complete proteome; Cytokine; Glycoprotein; Polymorphism;
Reference proteome; Repeat; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 229 Interleukin-27 subunit beta.
/FTId=PRO_0000010937.
DOMAIN 24 130 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 131 227 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
CARBOHYD 55 55 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 105 105 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VARIANT 174 174 A -> V (in dbSNP:rs1803524).
/FTId=VAR_049171.
VARIANT 201 201 V -> I (in dbSNP:rs4740).
{ECO:0000269|Ref.2, ECO:0000269|Ref.4}.
/FTId=VAR_024342.
CONFLICT 144 145 QL -> HV (in Ref. 1; AAA93193).
{ECO:0000305}.
SEQUENCE 229 AA; 25396 MW; CFBAD72D91859EF0 CRC64;
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV
SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP
FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV
GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK


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