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Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)

 IL3_MOUSE               Reviewed;         166 AA.
P01586;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
12-SEP-2018, entry version 150.
RecName: Full=Interleukin-3;
Short=IL-3;
AltName: Full=Hematopoietic growth factor;
AltName: Full=Mast cell growth factor;
Short=MCGF;
AltName: Full=Multipotential colony-stimulating factor;
AltName: Full=P-cell-stimulating factor;
Flags: Precursor;
Name=Il3; Synonyms=Csfmu, Il-3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6420702; DOI=10.1038/307233a0;
Fung M.-C., Hapel A.J., Ymer S., Cohen D.R., Johnson R.M.,
Campbell H.D., Young I.G.;
"Molecular cloning of cDNA for murine interleukin-3.";
Nature 307:233-237(1984).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=6322187; DOI=10.1073/pnas.81.4.1070;
Yokota T., Lee F., Rennick D., Hall C., Arai N., Mosmann T., Nabel G.,
Cantor H., Arai K.;
"Isolation and characterization of a mouse cDNA clone that expresses
mast-cell growth-factor activity in monkey cells.";
Proc. Natl. Acad. Sci. U.S.A. 81:1070-1074(1984).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3918308; DOI=10.1073/pnas.82.2.316;
Miyatake S., Yokota T., Lee F., Arai K.;
"Structure of the chromosomal gene for murine interleukin 3.";
Proc. Natl. Acad. Sci. U.S.A. 82:316-320(1985).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3926497; DOI=10.1111/j.1432-1033.1985.tb09020.x;
Campbell H.D., Ymer S., Fung M.-C., Young I.G.;
"Cloning and nucleotide sequence of the murine interleukin-3 gene.";
Eur. J. Biochem. 150:297-304(1985).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=DDD;
PubMed=3935516; DOI=10.1016/0378-1119(85)90114-3;
Todokoro K., Yamamoto A., Amanuma H., Ikawa Y.;
"Isolation and characterization of a genomic DDD mouse interleukin-3
gene.";
Gene 39:103-107(1985).
[6]
GLYCOSYLATION AT ASN-42 AND ASN-112, AND DISULFIDE BONDS.
PubMed=1445902; DOI=10.1021/bi00161a053;
Knepper T.P., Arbogast B., Schreurs J., Deinzer M.L.;
"Determination of the glycosylation patterns, disulfide linkages, and
protein heterogeneities of baculovirus-expressed mouse interleukin-3
by mass spectrometry.";
Biochemistry 31:11651-11659(1992).
[7]
STRUCTURE BY NMR OF 33-156, AND DISULFIDE BOND.
PubMed=21329364; DOI=10.1021/bi101810f;
Yao S., Young I.G., Norton R.S., Murphy J.M.;
"Murine interleukin-3: structure, dynamics, and conformational
heterogeneity in solution.";
Biochemistry 50:2464-2477(2011).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages.
-!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells,
stem cells, erythroid cells, eosinophils and megakaryocytes.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
cells.
-!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; K01850; AAA39291.1; -; mRNA.
EMBL; K01668; AAA39507.1; -; mRNA.
EMBL; K03233; AAA39293.1; -; Genomic_DNA.
EMBL; X02732; CAA26514.1; -; Genomic_DNA.
EMBL; M20128; AAA39308.1; -; Genomic_DNA.
EMBL; M14394; AAA39308.1; JOINED; Genomic_DNA.
CCDS; CCDS24693.1; -.
PIR; A25481; ICMS3.
RefSeq; NP_034686.2; NM_010556.4.
UniGene; Mm.983; -.
PDB; 2L3O; NMR; -; A=33-156.
PDBsum; 2L3O; -.
ProteinModelPortal; P01586; -.
SMR; P01586; -.
STRING; 10090.ENSMUSP00000019058; -.
iPTMnet; P01586; -.
PaxDb; P01586; -.
PRIDE; P01586; -.
Ensembl; ENSMUST00000019058; ENSMUSP00000019058; ENSMUSG00000018914.
GeneID; 16187; -.
KEGG; mmu:16187; -.
UCSC; uc007ixn.1; mouse.
CTD; 3562; -.
MGI; MGI:96552; Il3.
GeneTree; ENSGT00520000059953; -.
HOGENOM; HOG000113051; -.
HOVERGEN; HBG006148; -.
InParanoid; P01586; -.
KO; K04736; -.
OMA; SGRDTHR; -.
OrthoDB; EOG091G15R6; -.
PhylomeDB; P01586; -.
TreeFam; TF338567; -.
PRO; PR:P01586; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000018914; Expressed in 7 organ(s), highest expression level in muscle tissue.
CleanEx; MM_IL3; -.
ExpressionAtlas; P01586; baseline and differential.
Genevisible; P01586; MM.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0005125; F:cytokine activity; IDA:MGI.
GO; GO:0008083; F:growth factor activity; IDA:MGI.
GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
GO; GO:0005135; F:interleukin-3 receptor binding; IPI:MGI.
GO; GO:0042976; P:activation of Janus kinase activity; IDA:MGI.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
GO; GO:0001660; P:fever generation; IBA:GO_Central.
GO; GO:0030097; P:hemopoiesis; ISO:MGI.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0038156; P:interleukin-3-mediated signaling pathway; IDA:MGI.
GO; GO:0030224; P:monocyte differentiation; IGI:MGI.
GO; GO:0033028; P:myeloid cell apoptotic process; IDA:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
GO; GO:0010507; P:negative regulation of autophagy; IDA:MGI.
GO; GO:0033026; P:negative regulation of mast cell apoptotic process; IDA:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO; GO:0046330; P:positive regulation of JNK cascade; IDA:MGI.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IDA:MGI.
GO; GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IGI:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.
GO; GO:0001558; P:regulation of cell growth; IGI:MGI.
GO; GO:0010468; P:regulation of gene expression; IDA:MGI.
GO; GO:0006110; P:regulation of glycolytic process; IGI:MGI.
GO; GO:0035304; P:regulation of protein dephosphorylation; IDA:MGI.
GO; GO:0009725; P:response to hormone; ISO:MGI.
GO; GO:0001666; P:response to hypoxia; IGI:MGI.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002183; IL-3.
Pfam; PF02059; IL3; 1.
PIRSF; PIRSF001939; IL-3; 1.
PRINTS; PR00430; INTERLEUKIN3.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 26
CHAIN 27 166 Interleukin-3.
/FTId=PRO_0000015519.
CARBOHYD 42 42 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:1445902}.
CARBOHYD 112 112 N-linked (GlcNAc...) asparagine; partial.
{ECO:0000269|PubMed:1445902}.
DISULFID 43 106 {ECO:0000269|PubMed:1445902}.
DISULFID 105 166 {ECO:0000269|PubMed:1445902}.
STRAND 37 41 {ECO:0000244|PDB:2L3O}.
HELIX 44 53 {ECO:0000244|PDB:2L3O}.
HELIX 67 69 {ECO:0000244|PDB:2L3O}.
TURN 71 73 {ECO:0000244|PDB:2L3O}.
HELIX 74 85 {ECO:0000244|PDB:2L3O}.
TURN 86 88 {ECO:0000244|PDB:2L3O}.
HELIX 90 93 {ECO:0000244|PDB:2L3O}.
HELIX 97 106 {ECO:0000244|PDB:2L3O}.
HELIX 124 137 {ECO:0000244|PDB:2L3O}.
STRAND 140 142 {ECO:0000244|PDB:2L3O}.
STRAND 151 153 {ECO:0000244|PDB:2L3O}.
SEQUENCE 166 AA; 18540 MW; F38EE7A9E361CAA2 CRC64;
MVLASSTTSI HTMLLLLLML FHLGLQASIS GRDTHRLTRT LNCSSIVKEI IGKLPEPELK
TDDEGPSLRN KSFRRVNLSK FVESQGEVDP EDRYVIKSNL QKLNCCLPTS ANDSALPGVF
IRDLDDFRKK LRFYMVHLND LETVLTSRPP QPASGSVSPN RGTVEC


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