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Interleukin-3 (IL-3) (Hematopoietic growth factor) (Mast cell growth factor) (MCGF) (Multipotential colony-stimulating factor) (P-cell-stimulating factor)

 IL3_HUMAN               Reviewed;         152 AA.
P08700; Q6GS87;
01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 2.
25-OCT-2017, entry version 176.
RecName: Full=Interleukin-3;
Short=IL-3;
AltName: Full=Hematopoietic growth factor;
AltName: Full=Mast cell growth factor;
Short=MCGF;
AltName: Full=Multipotential colony-stimulating factor;
AltName: Full=P-cell-stimulating factor;
Flags: Precursor;
Name=IL3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3497843; DOI=10.1016/0378-1119(87)90254-X;
Dorssers L., Burger H., Bot F., Delwel R., Geurts van Kessel A.H.M.,
Loewenberg B., Wagemaker G.;
"Characterization of a human multilineage-colony-stimulating factor
cDNA clone identified by a conserved noncoding sequence in mouse
interleukin-3.";
Gene 55:115-124(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3127463;
Otsuka T., Miyajima A., Brown N., Otsu K., Abrams J., Saeland S.,
Caux C., de Waal Malefijt R., de Vries J., Meyerson P., Yokota K.,
Gemmel L., Rennick D., Lee F., Arai N., Arai K., Yokota T.;
"Isolation and characterization of an expressible cDNA encoding human
IL-3. Induction of IL-3 mRNA in human T cell clones.";
J. Immunol. 140:2288-2295(1988).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3489530; DOI=10.1016/0092-8674(86)90360-0;
Yang Y.-C., Ciarletta A.B., Temple P.A., Chung M.P., Kovacic S.,
Witek-Giannotti J.S., Leary A.C., Kriz R., Donahue R.E., Wong G.G.,
Clark S.C.;
"Human IL-3 (multi-CSF): identification by expression cloning of a
novel hematopoietic growth factor related to murine IL-3.";
Cell 47:3-10(1986).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-15 AND SER-27.
SeattleSNPs variation discovery resource;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15372022; DOI=10.1038/nature02919;
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
"The DNA sequence and comparative analysis of human chromosome 5.";
Nature 431:268-274(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-27.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE OF 20-152, AND VARIANT SER-27.
PubMed=2544122; DOI=10.1111/j.1749-6632.1989.tb22418.x;
Urdal D.L., Price V., Sassenfeld H.M., Cosman D., Gillis S.,
Park L.S.;
"Molecular characterization of colony-stimulating factors and their
receptors: human interleukin-3.";
Ann. N. Y. Acad. Sci. 554:167-176(1989).
[8]
STRUCTURE BY NMR.
PubMed=8676386; DOI=10.1006/jmbi.1996.0337;
Feng Y., Klein B.K., McWherter C.A.;
"Three-dimensional solution structure and backbone dynamics of a
variant of human interleukin-3.";
J. Mol. Biol. 259:524-541(1996).
-!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
cytokines that act in hematopoiesis by controlling the production,
differentiation, and function of 2 related white cell populations
of the blood, the granulocytes and the monocytes-macrophages.
-!- FUNCTION: This CSF induces granulocytes, macrophages, mast cells,
stem cells, erythroid cells, eosinophils and megakaryocytes.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Activated T-cells, mast cells, natural killer
cells.
-!- SIMILARITY: Belongs to the IL-3 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/IL3ID60.html";
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il3/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M14743; AAA59146.1; -; mRNA.
EMBL; M20137; AAA59147.1; -; mRNA.
EMBL; M17115; AAA35725.1; -; mRNA.
EMBL; AF365976; AAK38378.1; -; Genomic_DNA.
EMBL; AC004511; AAC08706.1; -; Genomic_DNA.
EMBL; BC066272; AAH66272.1; -; mRNA.
EMBL; BC066273; AAH66273.1; -; mRNA.
EMBL; BC066276; AAH66276.1; -; mRNA.
EMBL; BC069472; AAH69472.1; -; mRNA.
CCDS; CCDS4149.1; -.
PIR; A24427; A24427.
RefSeq; NP_000579.2; NM_000588.3.
UniGene; Hs.694; -.
PDB; 1JLI; NMR; -; A=34-144.
PDBsum; 1JLI; -.
ProteinModelPortal; P08700; -.
SMR; P08700; -.
BioGrid; 109777; 3.
DIP; DIP-6N; -.
IntAct; P08700; 1.
STRING; 9606.ENSP00000296870; -.
DrugBank; DB01025; Amlexanox.
BioMuta; IL3; -.
DMDM; 124330; -.
PaxDb; P08700; -.
PeptideAtlas; P08700; -.
PRIDE; P08700; -.
TopDownProteomics; P08700; -.
DNASU; 3562; -.
Ensembl; ENST00000296870; ENSP00000296870; ENSG00000164399.
GeneID; 3562; -.
KEGG; hsa:3562; -.
UCSC; uc003kwe.2; human.
CTD; 3562; -.
DisGeNET; 3562; -.
EuPathDB; HostDB:ENSG00000164399.4; -.
GeneCards; IL3; -.
HGNC; HGNC:6011; IL3.
MIM; 147740; gene.
neXtProt; NX_P08700; -.
OpenTargets; ENSG00000164399; -.
PharmGKB; PA29830; -.
eggNOG; ENOG410JJGT; Eukaryota.
eggNOG; ENOG411147A; LUCA.
GeneTree; ENSGT00730000111772; -.
HOGENOM; HOG000037939; -.
HOVERGEN; HBG004103; -.
InParanoid; P08700; -.
KO; K04736; -.
OMA; NCSNMID; -.
OrthoDB; EOG091G0W94; -.
PhylomeDB; P08700; -.
TreeFam; TF338567; -.
Reactome; R-HSA-114604; GPVI-mediated activation cascade.
Reactome; R-HSA-392451; G beta:gamma signalling through PI3Kgamma.
Reactome; R-HSA-512988; Interleukin-3, 5 and GM-CSF signaling.
Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
Reactome; R-HSA-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
Reactome; R-HSA-912526; Interleukin receptor SHC signaling.
SignaLink; P08700; -.
SIGNOR; P08700; -.
EvolutionaryTrace; P08700; -.
GeneWiki; Interleukin_3; -.
GenomeRNAi; 3562; -.
PRO; PR:P08700; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000164399; -.
CleanEx; HS_IL3; -.
Genevisible; P08700; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005149; F:interleukin-1 receptor binding; IBA:GO_Central.
GO; GO:0005135; F:interleukin-3 receptor binding; TAS:UniProtKB.
GO; GO:0004713; F:protein tyrosine kinase activity; TAS:Reactome.
GO; GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; TAS:Reactome.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0035162; P:embryonic hemopoiesis; IDA:DFLAT.
GO; GO:0001660; P:fever generation; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0000165; P:MAPK cascade; TAS:Reactome.
GO; GO:0007399; P:nervous system development; TAS:ProtInc.
GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
GO; GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:BHF-UCL.
GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; TAS:Reactome.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002183; IL-3.
Pfam; PF02059; IL3; 1.
PIRSF; PIRSF001939; IL-3; 1.
PRINTS; PR00430; INTERLEUKIN3.
SUPFAM; SSF47266; SSF47266; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Polymorphism; Reference proteome;
Secreted; Signal.
SIGNAL 1 19
CHAIN 20 152 Interleukin-3.
/FTId=PRO_0000015516.
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 89 89 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 35 103
VARIANT 3 3 R -> C (in dbSNP:rs35415145).
/FTId=VAR_034014.
VARIANT 15 15 R -> H (in dbSNP:rs2069787).
{ECO:0000269|Ref.4}.
/FTId=VAR_013071.
VARIANT 27 27 P -> S (in dbSNP:rs40401).
{ECO:0000269|PubMed:15489334,
ECO:0000269|PubMed:2544122,
ECO:0000269|Ref.4}.
/FTId=VAR_013072.
VARIANT 60 60 N -> S (in dbSNP:rs35482671).
/FTId=VAR_034015.
HELIX 35 45 {ECO:0000244|PDB:1JLI}.
HELIX 61 68 {ECO:0000244|PDB:1JLI}.
HELIX 73 86 {ECO:0000244|PDB:1JLI}.
HELIX 91 100 {ECO:0000244|PDB:1JLI}.
HELIX 101 103 {ECO:0000244|PDB:1JLI}.
HELIX 123 141 {ECO:0000244|PDB:1JLI}.
SEQUENCE 152 AA; 17233 MW; BB46F23FAC1259A4 CRC64;
MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP LPLLDFNNLN
GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL LPCLPLATAA PTRHPIHIKD
GDWNEFRRKL TFYLKTLENA QAQQTTLSLA IF


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