Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra)

 IL4_HUMAN               Reviewed;         153 AA.
P05112; Q14630; Q6NZ77;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
27-SEP-2017, entry version 205.
RecName: Full=Interleukin-4;
Short=IL-4;
AltName: Full=B-cell stimulatory factor 1;
Short=BSF-1;
AltName: Full=Binetrakin;
AltName: Full=Lymphocyte stimulatory factor 1;
AltName: Full=Pitrakinra;
Flags: Precursor;
Name=IL4;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
PubMed=3016727; DOI=10.1073/pnas.83.16.5894;
Yokota T., Otsuka T., Mosmann T., Banchereau J., Defrance T.,
Blanchard D., de Vries J.E., Lee F., Arai K.;
"Isolation and characterization of a human interleukin cDNA clone,
homologous to mouse B-cell stimulatory factor 1, that expresses B-
cell- and T-cell-stimulating activities.";
Proc. Natl. Acad. Sci. U.S.A. 83:5894-5898(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2535858;
Arai N., Nomura D., Villaret D., Malefijt R.D., Seiki M., Yoshida M.,
Minoshima S., Fukuyama R., Maekawa M., Kudoh J., Shimizu N.,
Yokota K., Abe E., Yokota T., Takebe Y., Arai K.;
"Complete nucleotide sequence of the chromosomal gene for human IL-4
and its expression.";
J. Immunol. 142:274-282(1989).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
PubMed=7806280; DOI=10.1007/BF00188440;
Klein S.C., Golverdingen J., Bouwens A.G.M., Tilanus M.G.J.;
"An alternatively spliced interleukin 4 form in lymphoid cells.";
Immunogenetics 41:57-57(1995).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
SeattleSNPs variation discovery resource;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Blood;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45.
PubMed=3257560; DOI=10.1093/nar/16.2.772;
Eder A., Krafft-Czepa H., Krammer P.H.;
"The 5' region of the human interleukin 4 gene: structure and
potential regulatory elements.";
Nucleic Acids Res. 16:772-772(1988).
[7]
PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-62, AND DISULFIDE
BONDS.
PubMed=1993171; DOI=10.1021/bi00220a011;
Carr C., Aykent S., Kimack N.M., Levine A.D.;
"Disulfide assignments in recombinant mouse and human interleukin 4.";
Biochemistry 30:1515-1523(1991).
[8]
X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
PubMed=1400355;
Walter M.R., Cook W.J., Zhao B.G., Cameron R.P. Jr., Ealick S.E.,
Walter R.L. Jr., Reichert P., Nagabhushan T.L., Trotta P.P.,
Bugg C.E.;
"Crystal structure of recombinant human interleukin-4.";
J. Biol. Chem. 267:20371-20376(1992).
[9]
X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
PubMed=1511746; DOI=10.1016/0014-5793(92)80739-4;
Wlodaver A., Pavlovsky A., Gustchina A.;
"Crystal structure of human recombinant interleukin-4 at 2.25-A
resolution.";
FEBS Lett. 309:59-64(1992).
[10]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-153 IN COMPLEX WITH
IL4RALPHA.
PubMed=10219247; DOI=10.1016/S0092-8674(00)80736-9;
Hage T., Sebald W., Reinemer P.;
"Crystal structure of the interleukin-4/receptor alpha chain complex
reveals a mosaic binding interface.";
Cell 97:271-281(1999).
[11]
STRUCTURE BY NMR.
PubMed=1932028; DOI=10.1021/bi00110a004;
Redfield C., Smith L.J., Boyd J., Lawrence G.M.P., Edwards R.G.,
Smith R.A.G., Dobson C.M.;
"Secondary structure and topology of human interleukin 4 in
solution.";
Biochemistry 30:11029-11035(1991).
[12]
STRUCTURE BY NMR.
PubMed=1569578; DOI=10.1016/0022-2836(92)90457-U;
Smith L.J., Redfield C., Boyd J., Lawrence G.M.P., Edwards R.G.,
Smith R.A.G., Dobson C.M.;
"Human interleukin 4. The solution structure of a four-helix bundle
protein.";
J. Mol. Biol. 224:899-904(1992).
[13]
STRUCTURE BY NMR.
PubMed=1567880; DOI=10.1021/bi00132a026;
Powers R., Garret D.S., March C.J., Frieden E.A., Gronenborn A.M.,
Clore G.M.;
"1H, 15N, 13C, and 13CO assignments of human interleukin-4 using
three-dimensional double- and triple-resonance heteronuclear magnetic
resonance spectroscopy.";
Biochemistry 31:4334-4346(1992).
[14]
STRUCTURE BY NMR.
PubMed=1567881; DOI=10.1021/bi00132a027;
Garret D.S., Powers R., March C.J., Frieden E.A., Clore G.M.,
Gronenborn A.M.;
"Determination of the secondary structure and folding topology of
human interleukin-4 using three-dimensional heteronuclear magnetic
resonance spectroscopy.";
Biochemistry 31:4347-4353(1992).
[15]
STRUCTURE BY NMR.
PubMed=1609277; DOI=10.1126/science.256.5064.1673;
Powers R., Garret D.S., March C.J., Frieden E.A., Gronenborn A.M.,
Clore G.M.;
"Three-dimensional solution structure of human interleukin-4 by
multidimensional heteronuclear magnetic resonance spectroscopy.";
Science 256:1673-1677(1992).
[16]
DISULFIDE BONDS, AND 3D-STRUCTURE MODELING.
PubMed=1946344; DOI=10.1002/prot.340110204;
Curtis B.M., Presnell S.R., Srinivasan S., Sassenfeld H., Klinke R.,
Jeffery E., Cosman D., March C.J., Cohen F.E.;
"Experimental and theoretical studies of the three-dimensional
structure of human interleukin-4.";
Proteins 11:111-119(1991).
[17]
MUTAGENESIS, AND STRUCTURE BY NMR.
PubMed=8151703; DOI=10.1006/jmbi.1994.1245;
Mueller T., Dieckmann T., Sebald W., Oschkinat H.;
"Aspects of receptor binding and signalling of interleukin-4
investigated by site-directed mutagenesis and NMR spectroscopy.";
J. Mol. Biol. 237:423-436(1994).
[18]
COMPARISON OF STRUCTURES.
PubMed=7664036; DOI=10.1038/nsb0594-301;
Smith L.J., Redfield C., Smith R.A.G., Dobson C.M., Clore G.M.,
Gronenborn A.M., Walter M.R., Naganbushan T.L., Wlodawer A.;
"Comparison of four independently determined structures of human
recombinant interleukin-4.";
Nat. Struct. Biol. 1:301-310(1994).
[19]
INVOLVEMENT IN SUSCEPTIBILITY TO ISCHSTR.
PubMed=14681304; DOI=10.1093/hmg/ddh039;
Zee R.Y.L., Cook N.R., Cheng S., Reynolds R., Erlich H.A.,
Lindpaintner K., Ridker P.M.;
"Polymorphism in the P-selectin and interleukin-4 genes as
determinants of stroke: a population-based, prospective genetic
analysis.";
Hum. Mol. Genet. 13:389-396(2004).
-!- FUNCTION: Participates in at least several B-cell activation
processes as well as of other cell types (PubMed:3016727). It is a
costimulator of DNA-synthesis. It induces the expression of class
II MHC molecules on resting B-cells. It enhances both secretion
and cell surface expression of IgE and IgG1. It also regulates the
expression of the low affinity Fc receptor for IgE (CD23) on both
lymphocytes and monocytes. Positively regulates IL31RA expression
in macrophages (By similarity). {ECO:0000250|UniProtKB:P07750,
ECO:0000269|PubMed:3016727}.
-!- INTERACTION:
P78552:IL13RA1; NbExp=3; IntAct=EBI-367025, EBI-1391535;
P24394:IL4R; NbExp=7; IntAct=EBI-367025, EBI-367009;
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Long;
IsoId=P05112-1; Sequence=Displayed;
Name=2; Synonyms=Short, IL-4delta2;
IsoId=P05112-2; Sequence=VSP_002672;
-!- DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an
acute neurologic event leading to death of neural tissue of the
brain and resulting in loss of motor, sensory and/or cognitive
function. Ischemic strokes, resulting from vascular occlusion, is
considered to be a highly complex disease consisting of a group of
heterogeneous disorders with multiple genetic and environmental
risk factors. {ECO:0000269|PubMed:14681304}. Note=Disease
susceptibility is associated with variations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il4/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M13982; AAA59149.1; -; mRNA.
EMBL; M23442; AAA59150.1; -; Genomic_DNA.
EMBL; X81851; CAA57444.1; -; mRNA.
EMBL; AF395008; AAK71324.1; -; Genomic_DNA.
EMBL; BC066277; AAH66277.1; -; mRNA.
EMBL; BC067514; AAH67514.1; -; mRNA.
EMBL; BC070123; AAH70123.1; -; mRNA.
EMBL; X06750; CAA29925.1; -; Genomic_DNA.
CCDS; CCDS4158.1; -. [P05112-1]
CCDS; CCDS4159.1; -. [P05112-2]
PIR; A30546; A25946.
RefSeq; NP_000580.1; NM_000589.3. [P05112-1]
RefSeq; NP_758858.1; NM_172348.2. [P05112-2]
UniGene; Hs.73917; -.
PDB; 1BBN; NMR; -; A=25-153.
PDB; 1BCN; NMR; -; A=25-153.
PDB; 1CYL; NMR; -; A=25-153.
PDB; 1HIJ; X-ray; 3.00 A; A=25-153.
PDB; 1HIK; X-ray; 2.60 A; A=25-153.
PDB; 1HZI; X-ray; 2.05 A; A=25-153.
PDB; 1IAR; X-ray; 2.30 A; A=25-153.
PDB; 1ILL; Model; -; 4=25-153.
PDB; 1ITE; Model; -; A=25-153.
PDB; 1ITI; NMR; -; A=25-153.
PDB; 1ITL; NMR; -; A=25-153.
PDB; 1ITM; NMR; -; A=25-153.
PDB; 1RCB; X-ray; 2.25 A; A=25-153.
PDB; 2B8U; X-ray; 1.80 A; A=25-153.
PDB; 2B8X; X-ray; 1.70 A; A=25-153.
PDB; 2B8Y; X-ray; 1.80 A; A=25-153.
PDB; 2B8Z; X-ray; 2.50 A; A=25-153.
PDB; 2B90; X-ray; 2.10 A; A=25-153.
PDB; 2B91; X-ray; 2.00 A; A=25-153.
PDB; 2CYK; NMR; -; A=25-153.
PDB; 2D48; X-ray; 1.65 A; A=25-153.
PDB; 2INT; X-ray; 2.35 A; A=25-153.
PDB; 3BPL; X-ray; 2.93 A; A=25-153.
PDB; 3BPN; X-ray; 3.02 A; A=25-153.
PDB; 3QB7; X-ray; 3.24 A; A/B=25-153.
PDB; 4YDY; X-ray; 2.00 A; I/J=25-153.
PDB; 5FHX; X-ray; 2.55 A; A=30-153.
PDBsum; 1BBN; -.
PDBsum; 1BCN; -.
PDBsum; 1CYL; -.
PDBsum; 1HIJ; -.
PDBsum; 1HIK; -.
PDBsum; 1HZI; -.
PDBsum; 1IAR; -.
PDBsum; 1ILL; -.
PDBsum; 1ITE; -.
PDBsum; 1ITI; -.
PDBsum; 1ITL; -.
PDBsum; 1ITM; -.
PDBsum; 1RCB; -.
PDBsum; 2B8U; -.
PDBsum; 2B8X; -.
PDBsum; 2B8Y; -.
PDBsum; 2B8Z; -.
PDBsum; 2B90; -.
PDBsum; 2B91; -.
PDBsum; 2CYK; -.
PDBsum; 2D48; -.
PDBsum; 2INT; -.
PDBsum; 3BPL; -.
PDBsum; 3BPN; -.
PDBsum; 3QB7; -.
PDBsum; 4YDY; -.
PDBsum; 5FHX; -.
ProteinModelPortal; P05112; -.
SMR; P05112; -.
BioGrid; 109779; 2.
CORUM; P05112; -.
DIP; DIP-3222N; -.
IntAct; P05112; 3.
MINT; MINT-90320; -.
STRING; 9606.ENSP00000231449; -.
ChEMBL; CHEMBL3712894; -.
iPTMnet; P05112; -.
PhosphoSitePlus; P05112; -.
BioMuta; IL4; -.
DMDM; 124337; -.
PaxDb; P05112; -.
PeptideAtlas; P05112; -.
PRIDE; P05112; -.
DNASU; 3565; -.
Ensembl; ENST00000231449; ENSP00000231449; ENSG00000113520. [P05112-1]
Ensembl; ENST00000350025; ENSP00000325190; ENSG00000113520. [P05112-2]
GeneID; 3565; -.
KEGG; hsa:3565; -.
UCSC; uc003kxk.3; human. [P05112-1]
CTD; 3565; -.
DisGeNET; 3565; -.
EuPathDB; HostDB:ENSG00000113520.10; -.
GeneCards; IL4; -.
H-InvDB; HIX0164435; -.
HGNC; HGNC:6014; IL4.
MIM; 147780; gene.
MIM; 601367; phenotype.
neXtProt; NX_P05112; -.
OpenTargets; ENSG00000113520; -.
PharmGKB; PA197; -.
eggNOG; KOG3886; Eukaryota.
eggNOG; ENOG410XQ0R; LUCA.
GeneTree; ENSGT00390000013108; -.
HOGENOM; HOG000254781; -.
HOVERGEN; HBG000290; -.
InParanoid; P05112; -.
KO; K05430; -.
OMA; LACTSNF; -.
OrthoDB; EOG091G0WDE; -.
PhylomeDB; P05112; -.
TreeFam; TF336383; -.
Reactome; R-HSA-6783783; Interleukin-10 signaling.
Reactome; R-HSA-6785807; Interleukin-4 and 13 signaling.
SignaLink; P05112; -.
SIGNOR; P05112; -.
EvolutionaryTrace; P05112; -.
GeneWiki; Interleukin_4; -.
GenomeRNAi; 3565; -.
PRO; PR:P05112; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000113520; -.
CleanEx; HS_IL4; -.
ExpressionAtlas; P05112; baseline and differential.
Genevisible; P05112; HS.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; TAS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; NAS:UniProtKB.
GO; GO:0005136; F:interleukin-4 receptor binding; TAS:UniProtKB.
GO; GO:0031296; P:B cell costimulation; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; TAS:UniProtKB.
GO; GO:0006968; P:cellular defense response; TAS:ProtInc.
GO; GO:0071288; P:cellular response to mercury ion; IEA:Ensembl.
GO; GO:0006935; P:chemotaxis; TAS:ProtInc.
GO; GO:0008203; P:cholesterol metabolic process; ISS:UniProtKB.
GO; GO:0045189; P:connective tissue growth factor biosynthetic process; TAS:UniProtKB.
GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
GO; GO:0097028; P:dendritic cell differentiation; IDA:DFLAT.
GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0002227; P:innate immune response in mucosa; IEA:Ensembl.
GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IDA:UniProtKB.
GO; GO:0002674; P:negative regulation of acute inflammatory response; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0002677; P:negative regulation of chronic inflammatory response; IEA:Ensembl.
GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IMP:AgBase.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IMP:AgBase.
GO; GO:0010633; P:negative regulation of epithelial cell migration; IDA:CACAO.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0043031; P:negative regulation of macrophage activation; IEA:Ensembl.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Ensembl.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
GO; GO:2000320; P:negative regulation of T-helper 17 cell differentiation; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0070351; P:negative regulation of white fat cell proliferation; IEA:Ensembl.
GO; GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IEA:Ensembl.
GO; GO:0002230; P:positive regulation of defense response to virus by host; IEA:Ensembl.
GO; GO:2000424; P:positive regulation of eosinophil chemotaxis; IEA:Ensembl.
GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
GO; GO:0032736; P:positive regulation of interleukin-13 production; IDA:UniProtKB.
GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IEA:Ensembl.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
GO; GO:0071677; P:positive regulation of mononuclear cell migration; IEA:Ensembl.
GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IDA:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
GO; GO:0045191; P:regulation of isotype switching; TAS:UniProtKB.
GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
GO; GO:0010155; P:regulation of proton transport; IEA:Ensembl.
GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
GO; GO:0002296; P:T-helper 1 cell lineage commitment; IEA:Ensembl.
GO; GO:0035745; P:T-helper 2 cell cytokine production; IDA:UniProtKB.
GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
GO; GO:0042092; P:type 2 immune response; TAS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002354; IL-4.
InterPro; IPR001325; IL-4/IL-13.
InterPro; IPR018096; IL-4/IL-13_CS.
PANTHER; PTHR10078:SF35; PTHR10078:SF35; 1.
Pfam; PF00727; IL4; 1.
PIRSF; PIRSF001941; Interleukin_4; 1.
PRINTS; PR00431; INTERLEUKIN4.
SMART; SM00190; IL4_13; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00838; INTERLEUKIN_4_13; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; B-cell activation;
Complete proteome; Cytokine; Direct protein sequencing;
Disulfide bond; Glycoprotein; Growth factor; Polymorphism;
Reference proteome; Secreted; Signal.
SIGNAL 1 24
CHAIN 25 153 Interleukin-4.
/FTId=PRO_0000015532.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000269|PubMed:1993171}.
DISULFID 27 151 {ECO:0000269|PubMed:1993171}.
DISULFID 48 89 {ECO:0000269|PubMed:1993171}.
DISULFID 70 123
VAR_SEQ 46 61 Missing (in isoform 2).
{ECO:0000303|PubMed:7806280}.
/FTId=VSP_002672.
VARIANT 27 27 C -> R (in dbSNP:rs4986964).
/FTId=VAR_020392.
TURN 26 29 {ECO:0000244|PDB:1BBN}.
HELIX 30 41 {ECO:0000244|PDB:2D48}.
HELIX 42 44 {ECO:0000244|PDB:5FHX}.
HELIX 48 50 {ECO:0000244|PDB:2D48}.
STRAND 51 54 {ECO:0000244|PDB:2D48}.
HELIX 56 58 {ECO:0000244|PDB:2D48}.
TURN 60 62 {ECO:0000244|PDB:1CYL}.
HELIX 65 83 {ECO:0000244|PDB:2D48}.
TURN 87 89 {ECO:0000244|PDB:2D48}.
HELIX 94 118 {ECO:0000244|PDB:2D48}.
STRAND 130 132 {ECO:0000244|PDB:2D48}.
HELIX 133 151 {ECO:0000244|PDB:2D48}.
SEQUENCE 153 AA; 17492 MW; 8725BF64B34D45F7 CRC64;
MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL
NSCPVKEANQ STLENFLERL KTIMREKYSK CSS


Related products :

Catalog number Product name Quantity
E0077h ELISA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
U0077h CLIA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
E0077h ELISA kit B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45213 Interleukin-4 (IL-4) Rat - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
E0077m ELISA kit B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus muscul 96T
E0077m ELISA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
U0077m CLIA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
E0077r ELISA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077r ELISA kit B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
U0077r CLIA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077Rb ELISA kit B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
E0077Rb ELISA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077Rb CLIA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077b CLIA B-cell stimulatory factor 1,Bos taurus,Bovine,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur