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Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1)

 IL4_CANLF               Reviewed;         132 AA.
O77762; A1E293;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
23-MAY-2018, entry version 107.
RecName: Full=Interleukin-4;
Short=IL-4;
AltName: Full=B-cell stimulatory factor 1;
Short=BSF-1;
AltName: Full=Lymphocyte stimulatory factor 1;
Flags: Precursor;
Name=IL4;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=9887351; DOI=10.1007/s002510050473;
van der Kaaij S.Y., Pinelli E., Broeren C.P.M., Schetters T.P.M.,
Haghparast A., Ruitenberg E.J., Rutten V.P.M.G.;
"Molecular cloning and sequencing of the cDNA for dog interleukin-4.";
Immunogenetics 49:142-143(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
Boroughs K.L., Dreitz M., Sim G.-K.;
"Cloning and expression of canine IL4.";
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Kobayashi H., Yoshida M., Nakagaki K., Katae H., Nogami S.,
Harasawa R., Maeda R., Hayashi Y., Yamamoto H.;
"Nucleotide sequence and deduced amino acid sequence of canine
interleukin 4 cDNA.";
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=10487243; DOI=10.1292/jvms.61.967;
Khatlani T.S., Ohno K., Ma Z., Inokuma H., Onishi T.;
"Cloning of a full length cDNA encoding canine interleukin-4.";
J. Vet. Med. Sci. 61:967-969(1999).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=11741347; DOI=10.1006/cyto.2001.0953;
Wondimu A., Veit M., Kohn B., Kaul S., Hoffmann A., Brunnberg L.,
Schmidt M.F.;
"Molecular cloning, expression and characterization of the Canis
familiaris interleukin-4.";
Cytokine 16:88-92(2001).
[6]
NUCLEOTIDE SEQUENCE [MRNA].
Salunkhe S.S., Rai A., Saxena A., Tiwari A.K., Gupta P.K.;
"Amplification and cloning of canine interleukin-4 in mammalian
expression vector.";
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Participates in at least several B-cell activation
processes as well as of other cell types. It is a costimulator of
DNA-synthesis. It induces the expression of class II MHC molecules
on resting B-cells. It enhances both secretion and cell surface
expression of IgE and IgG1. It also regulates the expression of
the low affinity Fc receptor for IgE (CD23) on both lymphocytes
and monocytes. Positively regulates IL31RA expression in
macrophages. {ECO:0000250|UniProtKB:P07750}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-4/IL-13 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF054833; AAD11563.1; -; mRNA.
EMBL; AF083270; AAD09005.1; -; mRNA.
EMBL; AF104245; AAC83931.1; -; mRNA.
EMBL; AF187322; AAF01043.1; -; mRNA.
EMBL; AF239917; AAF60177.1; -; mRNA.
EMBL; EF095771; ABL01502.1; -; mRNA.
RefSeq; NP_001003159.1; NM_001003159.1.
UniGene; Cfa.39; -.
ProteinModelPortal; O77762; -.
SMR; O77762; -.
STRING; 9615.ENSCAFP00000001253; -.
PaxDb; O77762; -.
PRIDE; O77762; -.
Ensembl; ENSCAFT00000001367; ENSCAFP00000001253; ENSCAFG00000000880.
GeneID; 403785; -.
KEGG; cfa:403785; -.
CTD; 3565; -.
VGNC; VGNC:41987; IL4.
eggNOG; KOG3886; Eukaryota.
eggNOG; ENOG410XQ0R; LUCA.
GeneTree; ENSGT00390000013108; -.
HOGENOM; HOG000254781; -.
HOVERGEN; HBG000290; -.
InParanoid; O77762; -.
KO; K05430; -.
OMA; LACTSNF; -.
OrthoDB; EOG091G0WDE; -.
Reactome; R-CFA-6785807; Interleukin-4 and 13 signaling.
Proteomes; UP000002254; Chromosome 11.
Bgee; ENSCAFG00000000880; -.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISS:UniProtKB.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISS:UniProtKB.
GO; GO:0048295; P:positive regulation of isotype switching to IgE isotypes; ISS:UniProtKB.
GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; ISS:UniProtKB.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISS:UniProtKB.
GO; GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0050776; P:regulation of immune response; ISS:UniProtKB.
GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002354; IL-4.
InterPro; IPR001325; IL-4/IL-13.
InterPro; IPR018096; IL-4/IL-13_CS.
Pfam; PF00727; IL4; 1.
PIRSF; PIRSF001941; Interleukin_4; 1.
PRINTS; PR00431; INTERLEUKIN4.
SMART; SM00190; IL4_13; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00838; INTERLEUKIN_4_13; 1.
2: Evidence at transcript level;
B-cell activation; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
SIGNAL 1 24 {ECO:0000250}.
CHAIN 25 132 Interleukin-4.
/FTId=PRO_0000015526.
CARBOHYD 28 28 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 95 95 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 101 101 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 48 84 {ECO:0000250}.
DISULFID 70 104 {ECO:0000250}.
SEQUENCE 132 AA; 15267 MW; 6F75D8FBB6818945 CRC64;
MGLTSQLIPT LVCLLALTST FVHGHNFNIT IKEIIKMLNI LTARNDSCME LTVKDVFTAP
KNTSDKEIFC RAATVLRQIY THNCSNRYLR GLYRNLSSMA NKTCSMNEIK KSTLKDFLER
LKVIMQKKYY RH


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