Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)

 Q6U8C1_MACMU            Unreviewed;       153 AA.
Q6U8C1; F7DGE5;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
07-NOV-2018, entry version 106.
RecName: Full=Interleukin-4 {ECO:0000256|PIRNR:PIRNR001941};
Short=IL-4 {ECO:0000256|PIRNR:PIRNR001941};
AltName: Full=B-cell stimulatory factor 1 {ECO:0000256|PIRNR:PIRNR001941};
AltName: Full=Lymphocyte stimulatory factor 1 {ECO:0000256|PIRNR:PIRNR001941};
Name=IL4 {ECO:0000313|Ensembl:ENSMMUP00000004188};
ORFNames=EGK_16838 {ECO:0000313|EMBL:EHH26775.1};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|EMBL:AAQ87962.1};
[1] {ECO:0000313|EMBL:AAQ87962.1}
NUCLEOTIDE SEQUENCE.
PubMed=12573592; DOI=10.1006/viro.2002.1763;
Stahl-Hennig C., Gundlach B.R., Dittmer U., ten Haaft P., Heeney J.,
Zou W., Emilie D., Sopper S., Uberla K.;
"Replication, immunogenicity, and protective properties of live-
attenuated simian immunodeficiency viruses expressing interleukin-4 or
interferon-gamma.";
Virology 305:473-485(2003).
[2] {ECO:0000313|Ensembl:ENSMMUP00000004188, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004188,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[3] {ECO:0000313|EMBL:EHH26775.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CR-5 {ECO:0000313|EMBL:EHH26775.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[4] {ECO:0000313|Ensembl:ENSMMUP00000004188}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004188};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: Participates in at least several B-cell activation
processes as well as of other cell types. It is a costimulator of
DNA-synthesis. It induces the expression of class II MHC molecules
on resting B-cells. It enhances both secretion and cell surface
expression of IgE and IgG1. It also regulates the expression of
the low affinity Fc receptor for IgE (CD23) on both lymphocytes
and monocytes. {ECO:0000256|PIRNR:PIRNR001941}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR001941}.
-!- SIMILARITY: Belongs to the IL-4/IL-13 family.
{ECO:0000256|PIRNR:PIRNR001941}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; JSUE03036924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY376144; AAQ87962.1; -; mRNA.
EMBL; CM001258; EHH26775.1; -; Genomic_DNA.
RefSeq; NP_001028076.1; NM_001032904.1.
UniGene; Mmu.3375; -.
Ensembl; ENSMMUT00000004439; ENSMMUP00000004188; ENSMMUG00000003133.
GeneID; 574281; -.
KEGG; mcc:574281; -.
CTD; 3565; -.
eggNOG; KOG3886; Eukaryota.
eggNOG; ENOG410XQ0R; LUCA.
GeneTree; ENSGT00390000013108; -.
HOVERGEN; HBG000290; -.
KO; K05430; -.
OMA; LACTSNF; -.
OrthoDB; EOG091G0WDE; -.
TreeFam; TF336383; -.
Proteomes; UP000006718; Chromosome 6.
Bgee; ENSMMUG00000003133; Expressed in 7 organ(s), highest expression level in CD4-positive helper T cell.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005136; F:interleukin-4 receptor binding; IEA:InterPro.
GO; GO:0042976; P:activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0042113; P:B cell activation; IEA:UniProtKB-UniRule.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:1903660; P:negative regulation of complement-dependent cytotoxicity; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0010633; P:negative regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0032736; P:positive regulation of interleukin-13 production; IEA:Ensembl.
GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0042110; P:T cell activation; IEA:Ensembl.
GO; GO:0035745; P:T-helper 2 cell cytokine production; IEA:Ensembl.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR002354; IL-4.
InterPro; IPR001325; IL-4/IL-13.
InterPro; IPR018096; IL-4/IL-13_CS.
Pfam; PF00727; IL4; 1.
PIRSF; PIRSF001941; Interleukin_4; 1.
PRINTS; PR00431; INTERLEUKIN4.
SMART; SM00190; IL4_13; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00838; INTERLEUKIN_4_13; 1.
2: Evidence at transcript level;
B-cell activation {ECO:0000256|PIRNR:PIRNR001941};
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Cytokine {ECO:0000256|PIRNR:PIRNR001941};
Disulfide bond {ECO:0000256|PIRSR:PIRSR001941-1};
Growth factor {ECO:0000256|PIRNR:PIRNR001941};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Secreted {ECO:0000256|PIRNR:PIRNR001941};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 24 {ECO:0000256|SAM:SignalP}.
CHAIN 25 153 Interleukin-4. {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014106659.
DISULFID 48 89 {ECO:0000256|PIRSR:PIRSR001941-1}.
DISULFID 70 123 {ECO:0000256|PIRSR:PIRSR001941-1}.
SEQUENCE 153 AA; 17465 MW; 0991262050669A0A CRC64;
MGLTSQLLPP LFFLLACAGN FAHGHNCHIA LREIIETLNS LTEQKTLCTK LTITDILAAS
KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL
NSCPVKEASQ STLEDFLERL KTIMKEKYSK CRS


Related products :

Catalog number Product name Quantity
E0077m ELISA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
E0077m ELISA kit B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus muscul 96T
U0077m CLIA B-cell growth factor 1,B-cell IgG differentiation factor,B-cell stimulatory factor 1,BSF-1,IGG1 induction factor,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Mouse,Mus musculus 96T
U0077r CLIA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077r ELISA B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
E0077r ELISA kit B-cell growth factor 1,B-cell IGG differentiation factor,B-cell stimulatory factor 1,BSF-1,Il4,IL-4,Il-4,Interleukin-4,Lymphocyte stimulatory factor 1,Rat,Rattus norvegicus 96T
U0077h CLIA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
E0077h ELISA kit B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
E0077h ELISA B-cell stimulatory factor 1,Binetrakin,BSF-1,Homo sapiens,Human,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra 96T
E0077Rb ELISA kit B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
E0077Rb ELISA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077Rb CLIA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Oryctolagus cuniculus,Rabbit 96T
U0077b CLIA B-cell stimulatory factor 1,Bos taurus,Bovine,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1 96T
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45081 Interleukin-4 (IL-4) Human - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45135 Interleukin-4 (IL-4) Murine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
E0077b ELISA B-cell stimulatory factor 1,Bos taurus,Bovine,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1 96T
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.002 mg
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 1 mg
E0077b ELISA kit B-cell stimulatory factor 1,Bos taurus,Bovine,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1 96T
10-663-45225 Interleukin-4 (IL-4) Porcine - IL-4; B-cell stimulatory factor 1; BSF-1; Lymphocyte stimulatory factor 1; Binetrakin; Pitrakinra N_A 0.01 mg
E0077p ELISA B-cell stimulatory factor 1,BSF-1,IL4,IL-4,Interleukin-4,Lymphocyte stimulatory factor 1,Pig,Sus scrofa 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur