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Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124)

 IL4RA_HORSE             Reviewed;         809 AA.
Q6WG24; Q8MIR9;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 2.
28-FEB-2018, entry version 101.
RecName: Full=Interleukin-4 receptor subunit alpha;
Short=IL-4 receptor subunit alpha;
Short=IL-4R subunit alpha;
Short=IL-4R-alpha;
Short=IL-4RA;
AltName: CD_antigen=CD124;
Flags: Precursor;
Name=IL4R;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS VAL-464;
SER-554; THR-559 AND ALA-572.
TISSUE=Monocyte;
PubMed=14741137; DOI=10.1016/j.vetimm.2003.09.004;
Solberg O.D., Jackson K.A., Millon L.V., Stott J.L., Vandenplas M.L.,
Moore J.N., Watson J.L.;
"Genomic characterization of equine interleukin-4 receptor alpha-chain
(IL4R).";
Vet. Immunol. Immunopathol. 97:187-194(2004).
-!- FUNCTION: Receptor for both interleukin 4 and interleukin 13.
Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is
involved in promoting Th2 differentiation. The IL4/IL13 responses
are involved in regulating IgE production and, chemokine and mucus
production at sites of allergic inflammation. In certain cell
types, can signal through activation of insulin receptor
substrates, IRS1/IRS2 (By similarity). {ECO:0000250}.
-!- SUBUNIT: The functional IL4 receptor is formed by initial binding
of IL4 to IL4R. Subsequent recruitment to the complex of the
common gamma chain, in immune cells, creates a type I receptor
and, in non-immune cells, of IL13RA1 forms a type II receptor.
IL4R can also interact with the IL13/IL13RA1 complex to form a
similar type II receptor. Interacts with PIK3C3. Interacts with
the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and
INPP5D/SHIP. Interacts with JAK1 through a Box 1-containing
region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4
signaling. Interacts with JAK3. Interacts with CLM1.
{ECO:0000250|UniProtKB:P16382, ECO:0000250|UniProtKB:P24394}.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein.
-!- SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=Membrane form;
IsoId=Q6WG24-1; Sequence=Displayed;
Name=2; Synonyms=Soluble form;
IsoId=Q6WG24-2; Sequence=VSP_011114, VSP_011115;
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to
as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This
motif is involved in modulation of cellular responses. The
phosphorylated ITIM motif can bind the SH2 domain of several SH2-
containing phosphatases.
-!- PTM: On IL4 binding, phosphorylated on tyrosine residues in the
cytoplasmic domain. {ECO:0000250}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; AY081138; AAL87462.1; -; mRNA.
EMBL; AY289616; AAQ56236.1; -; mRNA.
RefSeq; NP_001075243.1; NM_001081774.2. [Q6WG24-1]
UniGene; Eca.21654; -.
UniGene; Eca.492; -.
ProteinModelPortal; Q6WG24; -.
SMR; Q6WG24; -.
STRING; 9796.ENSECAP00000019165; -.
PaxDb; Q6WG24; -.
PRIDE; Q6WG24; -.
GeneID; 791252; -.
KEGG; ecb:791252; -.
CTD; 3566; -.
eggNOG; ENOG410IGBQ; Eukaryota.
eggNOG; ENOG41124QC; LUCA.
HOGENOM; HOG000090263; -.
HOVERGEN; HBG052116; -.
InParanoid; Q6WG24; -.
KO; K05071; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
GO; GO:0002532; P:production of molecular mediator involved in inflammatory response; IEA:InterPro.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR015319; IL-4_rcpt-alpha_N.
Pfam; PF09238; IL4Ra_N; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
2: Evidence at transcript level;
Alternative splicing; Cell membrane; Complete proteome;
Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism;
Receptor; Reference proteome; Secreted; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 25 {ECO:0000250}.
CHAIN 26 809 Interleukin-4 receptor subunit alpha.
/FTId=PRO_0000010886.
TOPO_DOM 26 231 Extracellular. {ECO:0000255}.
TRANSMEM 232 255 Helical. {ECO:0000255}.
TOPO_DOM 256 809 Cytoplasmic. {ECO:0000255}.
DOMAIN 125 222 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 211 215 WSXWS motif.
MOTIF 261 269 Box 1 motif.
MOTIF 695 700 ITIM motif.
COMPBIAS 369 377 Poly-Glu.
MOD_RES 163 163 Phosphoserine.
{ECO:0000250|UniProtKB:P16382}.
MOD_RES 488 488 Phosphotyrosine.
{ECO:0000250|UniProtKB:P24394}.
MOD_RES 566 566 Phosphotyrosine.
{ECO:0000250|UniProtKB:P24394}.
MOD_RES 590 590 Phosphotyrosine.
{ECO:0000250|UniProtKB:P24394}.
MOD_RES 618 618 Phosphotyrosine.
{ECO:0000250|UniProtKB:P24394}.
CARBOHYD 53 53 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 112 112 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 128 128 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 175 175 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 208 208 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 34 44 {ECO:0000250}.
DISULFID 74 86 {ECO:0000250}.
VAR_SEQ 223 224 YY -> SP (in isoform 2).
{ECO:0000303|PubMed:14741137}.
/FTId=VSP_011114.
VAR_SEQ 225 809 Missing (in isoform 2).
{ECO:0000303|PubMed:14741137}.
/FTId=VSP_011115.
VARIANT 464 464 A -> V. {ECO:0000269|PubMed:14741137}.
VARIANT 554 554 A -> S. {ECO:0000269|PubMed:14741137}.
VARIANT 559 559 A -> T. {ECO:0000269|PubMed:14741137}.
VARIANT 572 572 V -> A. {ECO:0000269|PubMed:14741137}.
SEQUENCE 809 AA; 86735 MW; 55CFBA1358375DA0 CRC64;
MGCLCPGLTL PVSCLILVWA AGSGSVKVLR LTACFSDYIS ASTCEWKMDR PTNCSAQLRL
SYQLNDEFSD NLTCIPENRE DEVCVCRMLM DNIVSEDVYE LDLWAGNQLL WNSSFKPSRH
VKPRAPQNLT VHAISHTWLL TWSNPYPLKN HLWSELTYLV NISKEDDPTD FKIYNVTYMD
PTLRVTASTL KSRATYSARV KARAQNYNST WSEWSPSTTW HNYYEQPLEQ RLPLGVSISC
VVILAICLSC YFSIIKIKKE WWDQIPNPAH SPLVAIVLQD SQVSLWGKQS RGQEPAKCPR
WKTCLTKLLP CLLEHGLQKE EDSSKTVRNG PFQSPGKSAW HTVEVNHTIL RPEIISVVPC
VELCEAQVES EEEEVEEDRG SFCPSPESSG SGFQEGREGV AARLTESLFL GLLGAENGAL
GESCLLPPLG SAHMPWARIS SAGPQEAASQ GEEQPLNPES NPLATLTQSP GSLAFTEAPA
VVADNPAYRS FSNSLSQPRG PGELDSDPQL AEHLGQVDPS IPSAPQPSEP PTALQPEPET
WEQMLRQSVL QQGAAPAPAS APTGGYREFA QVVKQGGGAA GSGPSGEAGY KAFSSLLAGS
AVCPGQSGVE ASSGEGGYRP YESPDPGAPA PVPVPLFTFG LDVEPPHSPQ NSLLPGGSPE
LPGPEPTVKG EDPRKPLLSA QQATDSLRDD LGSGIVYSAL TCHLCGHLKQ CHGQEEHGEA
HTVASPCCGC CCGDRSSPPV SPVRALDPPP GGVPLEAGLS LASLGSLGLS EERKPSLFFQ
PAPGNAQSSS QTPLTVAMLS TGPTCTSAS


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