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Interleukin-6 (IL-6)

 IL6_BOVIN               Reviewed;         208 AA.
P26892; A9QWQ9; Q08DT2;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 1.
12-SEP-2018, entry version 129.
RecName: Full=Interleukin-6;
Short=IL-6;
Flags: Precursor;
Name=IL6;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Holstein;
PubMed=1446077; DOI=10.3109/10425179209020821;
Droogmans L., Cludts I., Cleuter Y., Kettmann R., Burny A.;
"Nucleotide sequence of bovine interleukin-6 cDNA.";
DNA Seq. 2:411-413(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Belted Galloway; TISSUE=Peripheral blood;
U.S. Veterinary Immune Reagent Network;
Hudgens T., Tompkins D., Baldwin C.L.;
"U.S. veterinary immune reagent network: expressed bovine gene
sequences.";
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Placenta;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cytokine with a wide variety of biological functions. It
is a potent inducer of the acute phase response. Plays an
essential role in the final differentiation of B-cells into Ig-
secreting cells Involved in lymphocyte and monocyte
differentiation. Acts on B-cells, T-cells, hepatocytes,
hematopoietic progenitor cells and cells of the CNS. Required for
the generation of T(H)17 cells. Also acts as a myokine. It is
discharged into the bloodstream after muscle contraction and acts
to increase the breakdown of fats and to improve insulin
resistance. It induces myeloma and plasmacytoma growth and induces
nerve cells differentiation (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; X57317; CAA40572.1; -; mRNA.
EMBL; EU276071; ABX72069.1; -; mRNA.
EMBL; BC123577; AAI23578.1; -; mRNA.
PIR; A56610; A56610.
RefSeq; NP_776348.1; NM_173923.2.
UniGene; Bt.3686; -.
ProteinModelPortal; P26892; -.
STRING; 9913.ENSBTAP00000019865; -.
PaxDb; P26892; -.
PRIDE; P26892; -.
Ensembl; ENSBTAT00000019865; ENSBTAP00000019865; ENSBTAG00000014921.
GeneID; 280826; -.
KEGG; bta:280826; -.
CTD; 3569; -.
VGNC; VGNC:30166; IL6.
eggNOG; ENOG410IW11; Eukaryota.
eggNOG; ENOG4112BXV; LUCA.
GeneTree; ENSGT00390000000878; -.
HOGENOM; HOG000236330; -.
HOVERGEN; HBG000471; -.
InParanoid; P26892; -.
KO; K05405; -.
OMA; LQAQNQW; -.
OrthoDB; EOG091G0NW5; -.
TreeFam; TF335984; -.
Reactome; R-BTA-1059683; Interleukin-6 signaling.
Reactome; R-BTA-110056; MAPK3 (ERK1) activation.
Reactome; R-BTA-112411; MAPK1 (ERK2) activation.
Reactome; R-BTA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
Reactome; R-BTA-8957275; Post-translational protein phosphorylation.
Proteomes; UP000009136; Chromosome 4.
Bgee; ENSBTAG00000014921; Expressed in 6 organ(s), highest expression level in lung.
GO; GO:0005615; C:extracellular space; NAS:AgBase.
GO; GO:0005896; C:interleukin-6 receptor complex; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0002384; P:hepatic immune response; IEA:Ensembl.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032966; P:negative regulation of collagen biosynthetic process; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0001781; P:neutrophil apoptotic process; IEA:Ensembl.
GO; GO:0002675; P:positive regulation of acute inflammatory response; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0050871; P:positive regulation of B cell activation; IEA:Ensembl.
GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0051024; P:positive regulation of immunoglobulin secretion; IEA:Ensembl.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0042102; P:positive regulation of T cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0010574; P:regulation of vascular endothelial growth factor production; IEA:Ensembl.
GO; GO:0051384; P:response to glucocorticoid; IEA:Ensembl.
GO; GO:0072540; P:T-helper 17 cell lineage commitment; ISS:UniProtKB.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003574; IL-6.
InterPro; IPR030474; IL-6/GCSF/MGF.
InterPro; IPR030473; IL6/GCSF/MGF_CS.
PANTHER; PTHR45110; PTHR45110; 1.
Pfam; PF00489; IL6; 1.
PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
PRINTS; PR00433; IL6GCSFMGF.
SMART; SM00126; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
PROSITE; PS00254; INTERLEUKIN_6; 1.
2: Evidence at transcript level;
Acute phase; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Growth factor; Phosphoprotein; Reference proteome;
Secreted; Signal.
SIGNAL 1 29 {ECO:0000250}.
CHAIN 30 208 Interleukin-6.
/FTId=PRO_0000015573.
MOD_RES 81 81 Phosphoserine.
{ECO:0000250|UniProtKB:P05231}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 72 78 {ECO:0000250}.
DISULFID 101 111 {ECO:0000250}.
SEQUENCE 208 AA; 23759 MW; A0F000B9BA2EC341 CRC64;
MNSRFTSAFT PFAVSLGLLL VMTSAFPTPG PLGEDFKNDT TPGRLLLTTP EKTEALIKRM
VDKISAMRKE ICEKNDECES SKETLAENKL NLPKMEEKDG CFQSGFNQAI CLIRTTAGLL
EYQIYLDYLQ NEYEGNQENV RDLRKNIRTL IQILKQKIAD LITTPATNTD LLEKMQSSNE
WVKNAKIILI LRNLENFLQF SLRAIRMK


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