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Interleukin-6 (IL-6) (sbIL-6)

 IL6_SPAAU               Reviewed;         225 AA.
B6CKP4;
03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
25-NOV-2008, sequence version 1.
25-OCT-2017, entry version 28.
RecName: Full=Interleukin-6;
Short=IL-6;
Short=sbIL-6;
Flags: Precursor;
Name=il6;
Sparus aurata (Gilthead sea bream).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Eupercaria; Spariformes; Sparidae; Sparus.
NCBI_TaxID=8175;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
PubMed=18513800; DOI=10.1016/j.molimm.2008.04.012;
Castellana B., Iliev D.B., Sepulcre M.P., MacKenzie S., Goetz F.W.,
Mulero V., Planas J.V.;
"Molecular characterization of interleukin-6 in the gilthead seabream
(Sparus aurata).";
Mol. Immunol. 45:3363-3370(2008).
-!- FUNCTION: Cytokine with a wide variety of biological functions. It
is a potent inducer of the acute phase response (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in white muscle, skin, spleen,
anterior intestine and stomach. Not expressed in brain, gill, head
kidney, posterior intestine and adipose tissue.
{ECO:0000269|PubMed:18513800}.
-!- INDUCTION: By LPS or Vibrio anguillarum infection.
{ECO:0000269|PubMed:18513800}.
-!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}.
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EMBL; EU244588; ABY76175.1; -; mRNA.
PRIDE; B6CKP4; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
GO; GO:0006955; P:immune response; IEA:InterPro.
InterPro; IPR009079; 4_helix_cytokine-like_core.
InterPro; IPR003574; IL-6.
Pfam; PF00489; IL6; 1.
SUPFAM; SSF47266; SSF47266; 1.
2: Evidence at transcript level;
Acute phase; Cytokine; Glycoprotein; Growth factor; Secreted; Signal.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 225 Interleukin-6.
/FTId=PRO_0000387951.
CARBOHYD 98 98 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 225 AA; 25598 MW; B2F8779C99D723DA CRC64;
MPSRLNVFWL CAAALAALLR CAPAAPVDGA FTDNPAGDTS GEEWETERPA DPLIALLKVV
LEVIKTHRQE FEAEFHIRYD VLAQYNIPSL PADCPSTNFS MEALLHRLLQ GLPVYTALLK
YVEKEEPKSQ IPSRFRQNSE LLKQRITGKM RHAVQVTPLT SSQEQQLLRD LDSSDTFHRK
MTAHSILYQL RSFLVDCKNA INKKEKLRES RANRAMTPVT LYYQS


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