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Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (CD antigen CD126)

 IL6RA_MOUSE             Reviewed;         460 AA.
P22272;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-AUG-1992, sequence version 2.
20-JUN-2018, entry version 176.
RecName: Full=Interleukin-6 receptor subunit alpha;
Short=IL-6 receptor subunit alpha;
Short=IL-6R subunit alpha;
Short=IL-6R-alpha;
Short=IL-6RA;
AltName: Full=IL-6R 1;
AltName: CD_antigen=CD126;
Flags: Precursor;
Name=Il6ra; Synonyms=Il6r;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/cJ; TISSUE=Spleen;
PubMed=2112585; DOI=10.1084/jem.171.6.2001;
Sugita T., Totsuka T., Saito M., Yamasaki K., Taga T., Hirano T.,
Kishimoto T.;
"Functional murine interleukin 6 receptor with the intracisternal A
particle gene product at its cytoplasmic domain. Its possible role in
plasmacytomagenesis.";
J. Exp. Med. 171:2001-2009(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C3H/HeJ; TISSUE=Liver;
Fiorillo M.T., Ciliberto G., Dente L.;
Submitted (JUL-1990) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Part of the receptor for interleukin 6. Binds to IL6
with low affinity, but does not transduce a signal. Signal
activation necessitate an association with IL6ST. Activation may
lead to the regulation of the immune response, acute-phase
reactions and hematopoiesis.
-!- SUBUNIT: Hexamer of two molecules each of IL6, IL6R and IL6ST.
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
protein.
-!- DOMAIN: The two fibronectin type-III-like domains contained in the
C-terminal part form together a cytokine-binding domain.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 3
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X51975; CAA36237.1; -; mRNA.
EMBL; X53802; CAA37810.1; -; mRNA.
CCDS; CCDS38496.1; -.
PIR; JL0144; JL0144.
PIR; JL0145; JL0145.
RefSeq; NP_034689.2; NM_010559.3.
UniGene; Mm.2856; -.
ProteinModelPortal; P22272; -.
SMR; P22272; -.
IntAct; P22272; 1.
STRING; 10090.ENSMUSP00000029559; -.
PhosphoSitePlus; P22272; -.
MaxQB; P22272; -.
PaxDb; P22272; -.
PRIDE; P22272; -.
DNASU; 16194; -.
Ensembl; ENSMUST00000029559; ENSMUSP00000029559; ENSMUSG00000027947.
GeneID; 16194; -.
KEGG; mmu:16194; -.
UCSC; uc008qaf.1; mouse.
CTD; 16194; -.
MGI; MGI:105304; Il6ra.
eggNOG; ENOG410II5K; Eukaryota.
eggNOG; ENOG4111XGC; LUCA.
GeneTree; ENSGT00530000063103; -.
HOGENOM; HOG000036902; -.
HOVERGEN; HBG052118; -.
InParanoid; P22272; -.
KO; K05055; -.
OMA; SNRDYFF; -.
OrthoDB; EOG091G07XD; -.
PhylomeDB; P22272; -.
TreeFam; TF331210; -.
Reactome; R-MMU-1059683; Interleukin-6 signaling.
Reactome; R-MMU-110056; MAPK3 (ERK1) activation.
Reactome; R-MMU-112411; MAPK1 (ERK2) activation.
PRO; PR:P22272; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000027947; -.
CleanEx; MM_IL6RA; -.
ExpressionAtlas; P22272; baseline and differential.
Genevisible; P22272; MM.
GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
GO; GO:0009986; C:cell surface; IDA:MGI.
GO; GO:0070110; C:ciliary neurotrophic factor receptor complex; ISO:MGI.
GO; GO:0005576; C:extracellular region; ISO:MGI.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005896; C:interleukin-6 receptor complex; ISO:MGI.
GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI.
GO; GO:0070119; F:ciliary neurotrophic factor binding; ISO:MGI.
GO; GO:0004897; F:ciliary neurotrophic factor receptor activity; IEA:Ensembl.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0019981; F:interleukin-6 binding; IDA:MGI.
GO; GO:0004915; F:interleukin-6 receptor activity; IDA:MGI.
GO; GO:0005138; F:interleukin-6 receptor binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0070120; P:ciliary neurotrophic factor-mediated signaling pathway; ISO:MGI.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
GO; GO:0048589; P:developmental growth; ISO:MGI.
GO; GO:0031018; P:endocrine pancreas development; ISO:MGI.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; IDA:MGI.
GO; GO:0032966; P:negative regulation of collagen biosynthetic process; ISO:MGI.
GO; GO:0010536; P:positive regulation of activation of Janus kinase activity; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI.
GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:MGI.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI.
GO; GO:0034097; P:response to cytokine; ISO:MGI.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003530; Hematopoietin_rcpt_L_F3_CS.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR013151; Immunoglobulin.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF00047; ig; 1.
Pfam; PF09240; IL6Ra-bind; 1.
SMART; SM00409; IG; 1.
SMART; SM00408; IGc2; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01354; HEMATOPO_REC_L_F3; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 19
CHAIN 20 460 Interleukin-6 receptor subunit alpha.
/FTId=PRO_0000010896.
TOPO_DOM 20 364 Extracellular. {ECO:0000255}.
TRANSMEM 365 385 Helical. {ECO:0000255}.
TOPO_DOM 386 460 Cytoplasmic. {ECO:0000255}.
DOMAIN 20 116 Ig-like C2-type.
DOMAIN 109 214 Fibronectin type-III 1.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
DOMAIN 215 313 Fibronectin type-III 2.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 300 304 WSXWS motif.
COMPBIAS 404 408 Poly-Pro.
CARBOHYD 32 32 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 55 55 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 150 150 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 25 190 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 47 92 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 117 128 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 162 173 {ECO:0000255|PROSITE-ProRule:PRU00114}.
CONFLICT 374 374 A -> R (in Ref. 2; CAA37810).
{ECO:0000305}.
SEQUENCE 460 AA; 50455 MW; F85C5906D08525C4 CRC64;
MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK EAAGNVTIHW
VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK
NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG
DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET
WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS VLAPVQESSS
MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK TTSPPPPPYS LGPLKPTFLL
VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD NSNRDYLFPR


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