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Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)

 IL7RA_HORSE             Reviewed;         458 AA.
A0MSX9;
14-APR-2009, integrated into UniProtKB/Swiss-Prot.
12-DEC-2006, sequence version 1.
25-OCT-2017, entry version 56.
RecName: Full=Interleukin-7 receptor subunit alpha;
Short=IL-7 receptor subunit alpha;
Short=IL-7R subunit alpha;
Short=IL-7R-alpha;
Short=IL-7RA;
AltName: CD_antigen=CD127;
Flags: Precursor;
Name=IL7R;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Kolebacova K.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for interleukin-7. Also acts as a receptor for
thymic stromal lymphopoietin (TSLP) (By similarity).
{ECO:0000250}.
-!- SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The
TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding. {ECO:0000250}.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation. {ECO:0000250}.
-!- PTM: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly
than the unglycosylated form. {ECO:0000250}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; EF035169; ABK34942.1; -; mRNA.
RefSeq; NP_001075411.1; NM_001081942.1.
UniGene; Eca.472; -.
ProteinModelPortal; A0MSX9; -.
SMR; A0MSX9; -.
STRING; 9796.ENSECAP00000008818; -.
PaxDb; A0MSX9; -.
GeneID; 100034169; -.
KEGG; ecb:100034169; -.
CTD; 3575; -.
eggNOG; ENOG410IGXR; Eukaryota.
eggNOG; ENOG410YWZG; LUCA.
HOGENOM; HOG000089950; -.
InParanoid; A0MSX9; -.
KO; K05072; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
Pfam; PF00041; fn3; 1.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
Membrane; Phosphoprotein; Receptor; Reference proteome; Signal;
Transmembrane; Transmembrane helix.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 458 Interleukin-7 receptor subunit alpha.
/FTId=PRO_0000369416.
TOPO_DOM 21 239 Extracellular. {ECO:0000255}.
TRANSMEM 240 260 Helical. {ECO:0000255}.
TOPO_DOM 261 458 Cytoplasmic. {ECO:0000255}.
DOMAIN 131 232 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 218 222 WSXWS motif. {ECO:0000250}.
MOTIF 271 279 Box 1 motif. {ECO:0000250}.
MOD_RES 281 281 Phosphothreonine; by PKC. {ECO:0000255}.
CARBOHYD 84 84 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 182 182 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 42 57 {ECO:0000250}.
DISULFID 74 82 {ECO:0000250}.
DISULFID 108 118 {ECO:0000250}.
SEQUENCE 458 AA; 51494 MW; E3178FFAAE089434 CRC64;
MTILGTTFGM VFYLLQVVSG ESGYAQNGDF EDAELDDYSF SCYSQLEVDG PQHLLSCAFE
DPDVNSTNLE FEICEGLLEV KCLNFSKLQE TYFIKTKKFL LIGDSTICVK LGGKHITCQK
LNIVKRVKPE APFDVKVIYR EEANEFVVTF NTSHLQKKYV KDLLHEVVYR LEKNENDWMH
VNISSTKLTL LQRKLQPNAM YEIKVRSIPN TNYFEGFWSE WSPSSHFRTP ENNSGKMDPV
LLIISIVSFF SVALMVILAC VLWKKRIKPI VWPSLPDHKK TLEQLCKKPK KNLNVSFNPE
SFLDCQIHKV DGIQARDEAE AFLQDTFPPQ LDDSEKQRLG GGVQGLNWPS QHAVITPKTF
GGESPLRCLS GSVTVCDVPV IPSSRPPDCR EGGKNGPHVY QGLLLGAGTT NSTLPHLFPF
QSGILTLNPA VQGQPLFTSL GSSQEEAYVT MSSFYQNQ


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