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Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (IL7Ra) (CD antigen CD127)

 IL7RA_MACFA             Reviewed;         459 AA.
Q38IC7;
14-APR-2009, integrated into UniProtKB/Swiss-Prot.
22-NOV-2005, sequence version 1.
25-OCT-2017, entry version 58.
RecName: Full=Interleukin-7 receptor subunit alpha;
Short=IL-7 receptor subunit alpha;
Short=IL-7R subunit alpha;
Short=IL-7R-alpha;
Short=IL-7RA;
Short=IL7Ra;
AltName: CD_antigen=CD127;
Flags: Precursor;
Name=IL7R;
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Chen S., Yu L.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Receptor for interleukin-7. Also acts as a receptor for
thymic stromal lymphopoietin (TSLP) (By similarity).
{ECO:0000250}.
-!- SUBUNIT: The IL7 receptor is a heterodimer of IL7R and IL2RG. The
TSLP receptor is a heterodimer of CRLF2 and IL7R (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type I membrane protein {ECO:0000250}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-
surface receptor binding. {ECO:0000250}.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation. {ECO:0000250}.
-!- PTM: N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly
than the unglycosylated form. {ECO:0000250}.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 4
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; DQ226543; ABB13531.1; -; mRNA.
RefSeq; NP_001271837.1; NM_001284908.1.
UniGene; Mfa.5388; -.
ProteinModelPortal; Q38IC7; -.
SMR; Q38IC7; -.
GeneID; 102143679; -.
KEGG; mcf:102143679; -.
CTD; 3575; -.
KO; K05072; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
Pfam; PF00041; fn3; 1.
SUPFAM; SSF49265; SSF49265; 1.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
2: Evidence at transcript level;
Cell membrane; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein;
Receptor; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 459 Interleukin-7 receptor subunit alpha.
/FTId=PRO_0000369417.
TOPO_DOM 21 240 Extracellular. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TOPO_DOM 262 459 Cytoplasmic. {ECO:0000255}.
DOMAIN 131 231 Fibronectin type-III.
{ECO:0000255|PROSITE-ProRule:PRU00316}.
MOTIF 217 221 WSXWS motif. {ECO:0000250}.
MOTIF 272 280 Box 1 motif. {ECO:0000250}.
MOD_RES 282 282 Phosphothreonine; by PKC. {ECO:0000255}.
CARBOHYD 49 49 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 65 65 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 182 182 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 42 57 {ECO:0000250}.
DISULFID 74 82 {ECO:0000250}.
DISULFID 108 118 {ECO:0000250}.
SEQUENCE 459 AA; 51665 MW; 5BA043C5D63FF7BD CRC64;
MTILGTTFGM VFSLLQVVSG ESGYAQNGDL EDAELDDYSF SCYSQLEVNG SQHSLTCAFE
DPDVNTTNLE FEICGALVEV KCLSFRKLQE IYFIETKKFL LIGKSNICVK VGGKSLTCKK
IDLTTIVKPE APFDLSVIYR EGANDFVVTF NTSHLQKKYV KVLMHDVAYR QEKDENKWMH
VNLSSTKLTL LQRNLQPEAM YEIKVRSIPD HYFKGFWSEW SPSYYFRTPE INNSPGEMDP
ILLTISLLSF FSVALLVILA CVLWKKRIKP IVWPSLPDHK KTLEHLCKKP RKNLNVSFNP
ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESKKQRL GGDVQSPSCP SEDVVITPES
FERDSSLRCL AGNVSACDAP ILSSSRSLDC RESGKNGPHV YQDLLLSLGT TNSTLPPPFS
LQSGILTLNP VAQGQPILTS LGSNQEEAYV TMSSFYQNQ


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