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Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8)

 IL8_CANLF               Reviewed;         101 AA.
P41324;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
25-OCT-2017, entry version 119.
RecName: Full=Interleukin-8;
Short=IL-8;
AltName: Full=C-X-C motif chemokine 8;
AltName: Full=Chemokine (C-X-C motif) ligand 8;
Flags: Precursor;
Name=CXCL8; Synonyms=IL8;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=7916715; DOI=10.1016/0378-1119(93)90313-R;
Ishikawa J., Suzuki S., Hotta K., Hirota Y., Mizuno S., Suzuki K.;
"Cloning of a canine gene homologous to the human interleukin-8-
encoding gene.";
Gene 131:305-306(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymph node;
PubMed=7827282; DOI=10.1016/1043-4666(94)90071-X;
Matsumoto Y., Mohamed A., Onodera T., Kato H., Ohashi T., Goitsuka R.,
Tsujimoto H., Hasegawa A., Furusawa S., Yoshihara K., Ishikawa J.,
Hotta K., Suzuki K., Hirota Y.;
"Molecular cloning and expression of canine interleukin 8 cDNA.";
Cytokine 6:455-461(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Mongrel; TISSUE=Jugular vein;
PubMed=7814650; DOI=10.1172/JCI117680;
Kukielka G.L., Smith W.C., Larosa G.J., Manning A.M., Mendoza L.H.,
Daly T.J., Hughes B.J., Youker K.A., Hawkins H.K., Michael L.H.,
Rot A., Entman M.L.;
"Interleukin-8 gene induction in the myocardium after ischemia and
reperfusion in vivo.";
J. Clin. Invest. 95:89-103(1995).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle;
PubMed=9119462;
Straubinger R.K., Straubinger A.F., Harter L., Jacobson R.H.,
Chang Y.-F., Summers B.A., Erb H.N., Appel M.J.;
"Borrelia burgdorferi migrates into joint capsules and causes an up-
regulation of interleukin-8 in synovial membranes of dogs
experimentally infected with ticks.";
Infect. Immun. 65:1273-1285(1997).
-!- FUNCTION: IL-8 is a chemotactic factor that attracts neutrophils,
basophils, and T-cells, but not monocytes. It is also involved in
neutrophil activation. It is released from several cell types in
response to an inflammatory stimulus.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Citrullination at Arg-27 prevents proteolysis, and dampens
tissue inflammation, it also enhances leukocytosis, possibly
through impaired chemokine clearance from the blood circulation.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; D28772; BAA05961.1; -; mRNA.
EMBL; D14285; BAA03246.1; -; Genomic_DNA.
EMBL; U10308; AAC48434.1; -; mRNA.
EMBL; AF048717; AAC05134.1; -; mRNA.
PIR; JN0841; JN0841.
RefSeq; NP_001003200.1; NM_001003200.1.
UniGene; Cfa.3510; -.
ProteinModelPortal; P41324; -.
SMR; P41324; -.
STRING; 9615.ENSCAFP00000004516; -.
PaxDb; P41324; -.
Ensembl; ENSCAFT00000004871; ENSCAFP00000004516; ENSCAFG00000003029.
GeneID; 403850; -.
KEGG; cfa:403850; -.
CTD; 3576; -.
eggNOG; ENOG410J24U; Eukaryota.
eggNOG; ENOG410Z1BP; LUCA.
GeneTree; ENSGT00530000062901; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P41324; -.
KO; K10030; -.
OMA; PTAPWVQ; -.
OrthoDB; EOG091G13J8; -.
TreeFam; TF333433; -.
Reactome; R-CFA-375276; Peptide ligand-binding receptors.
Reactome; R-CFA-380108; Chemokine receptors bind chemokines.
Reactome; R-CFA-418594; G alpha (i) signalling events.
Proteomes; UP000002254; Chromosome 13.
Bgee; ENSCAFG00000003029; -.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
GO; GO:0005153; F:interleukin-8 receptor binding; IEA:Ensembl.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; IBA:GO_Central.
GO; GO:0050930; P:induction of positive chemotaxis; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IBA:GO_Central.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:2000535; P:regulation of entry of bacterium into host cell; IEA:Ensembl.
GO; GO:0045091; P:regulation of single stranded viral RNA replication via double stranded DNA intermediate; IEA:Ensembl.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
GO; GO:0032496; P:response to lipopolysaccharide; IBA:GO_Central.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR028469; Interleukin-8.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF70; PTHR10179:SF70; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
3: Inferred from homology;
Chemotaxis; Citrullination; Complete proteome; Cytokine;
Disulfide bond; Inflammatory response; Reference proteome; Secreted;
Signal.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 101 Interleukin-8.
/FTId=PRO_0000005121.
MOD_RES 27 27 Citrulline. {ECO:0000250}.
DISULFID 34 61 {ECO:0000250}.
DISULFID 36 77 {ECO:0000250}.
SEQUENCE 101 AA; 11280 MW; 3A3A4676DA968376 CRC64;
MTSKLAVALL AAFVLSAALC EAAVLSRVSS ELRCQCIKTH STPFHPKYIK ELRVIDSGPH
CENSEIIVKL FNGNEVCLDP KEKWVQKVVQ IFLKKAEKQD P


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