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Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Neutrophil attractant/activation protein 1) (NAP-1) (Permeability factor 1) (PF1) (rPF1)

 IL8_RABIT               Reviewed;         101 AA.
P19874;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 2.
25-OCT-2017, entry version 120.
RecName: Full=Interleukin-8;
Short=IL-8;
AltName: Full=C-X-C motif chemokine 8;
AltName: Full=Chemokine (C-X-C motif) ligand 8;
AltName: Full=Neutrophil attractant/activation protein 1;
Short=NAP-1;
AltName: Full=Permeability factor 1;
Short=PF1;
Short=rPF1;
Flags: Precursor;
Name=CXCL8; Synonyms=IL8;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=New Zealand white; TISSUE=Spleen;
PubMed=2026877;
Yoshimura T., Yuhki N.;
"Neutrophil attractant/activation protein-1 and monocyte
chemoattractant protein-1 in rabbit. cDNA cloning and their expression
in spleen cells.";
J. Immunol. 146:3483-3488(1991).
[2]
PROTEIN SEQUENCE OF 23-53.
STRAIN=New Zealand white; TISSUE=Peritoneal cavity;
PubMed=2244880; DOI=10.1042/bj2710797;
Beaubien B.C., Collins P.D., Jose P.J., Totty N.F., Hsuan J.,
Waterfield M.D., Williams T.J.;
"A novel neutrophil chemoattractant generated during an inflammatory
reaction in the rabbit peritoneal cavity in vivo. Purification,
partial amino acid sequence and structural relationship to interleukin
8.";
Biochem. J. 271:797-801(1990).
-!- FUNCTION: IL-8 is a chemotactic factor that attracts neutrophils,
basophils, and T-cells, but not monocytes. It is also involved in
neutrophil activation. It is released from several cell types in
response to an inflammatory stimulus.
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Citrullination at Arg-27 prevents proteolysis, and dampens
tissue inflammation, it also enhances leukocytosis, possibly
through impaired chemokine clearance from the blood circulation.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
family. {ECO:0000305}.
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EMBL; M57439; AAA31422.1; -; mRNA.
PIR; I46871; I46871.
RefSeq; NP_001075762.1; NM_001082293.1.
UniGene; Ocu.1938; -.
ProteinModelPortal; P19874; -.
SMR; P19874; -.
STRING; 9986.ENSOCUP00000010171; -.
Ensembl; ENSOCUT00000030077; ENSOCUP00000018795; ENSOCUG00000011835.
GeneID; 100009129; -.
KEGG; ocu:100009129; -.
CTD; 3576; -.
eggNOG; ENOG410J24U; Eukaryota.
eggNOG; ENOG410Z1BP; LUCA.
GeneTree; ENSGT00530000062901; -.
HOGENOM; HOG000220915; -.
HOVERGEN; HBG107789; -.
InParanoid; P19874; -.
KO; K10030; -.
OMA; PTAPWVQ; -.
OrthoDB; EOG091G13J8; -.
Proteomes; UP000001811; Chromosome 15.
Bgee; ENSOCUG00000011835; -.
GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
GO; GO:0005153; F:interleukin-8 receptor binding; ISS:UniProtKB.
GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0050930; P:induction of positive chemotaxis; ISS:UniProtKB.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IEA:Ensembl.
GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0090023; P:positive regulation of neutrophil chemotaxis; IDA:UniProtKB.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0030155; P:regulation of cell adhesion; ISS:UniProtKB.
GO; GO:2000535; P:regulation of entry of bacterium into host cell; IEA:Ensembl.
GO; GO:0045091; P:regulation of single stranded viral RNA replication via double stranded DNA intermediate; ISS:UniProtKB.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
CDD; cd00273; Chemokine_CXC; 1.
InterPro; IPR001089; Chemokine_CXC.
InterPro; IPR018048; Chemokine_CXC_CS.
InterPro; IPR001811; Chemokine_IL8-like_dom.
InterPro; IPR033899; CXC_Chemokine_domain.
InterPro; IPR028469; Interleukin-8.
InterPro; IPR036048; Interleukin_8-like_sf.
PANTHER; PTHR10179; PTHR10179; 1.
PANTHER; PTHR10179:SF70; PTHR10179:SF70; 1.
Pfam; PF00048; IL8; 1.
PRINTS; PR00437; SMALLCYTKCXC.
SMART; SM00199; SCY; 1.
SUPFAM; SSF54117; SSF54117; 1.
PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
1: Evidence at protein level;
Chemotaxis; Citrullination; Complete proteome; Cytokine;
Direct protein sequencing; Disulfide bond; Inflammatory response;
Reference proteome; Secreted; Signal.
SIGNAL 1 22 {ECO:0000269|PubMed:2244880}.
CHAIN 23 101 Interleukin-8.
/FTId=PRO_0000005135.
MOD_RES 27 27 Citrulline. {ECO:0000250}.
DISULFID 34 61 {ECO:0000250}.
DISULFID 36 77 {ECO:0000250}.
CONFLICT 50 50 K -> I (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 101 AA; 11403 MW; 152B110C43AD8726 CRC64;
MNSKLAVALL ATFLLSLTLC EAAVLTRIGT ELRCQCIKTH STPFHPKFIK ELRVIESGPH
CANSEIIVKL VDGRELCLDP KEKWVQKVVQ IFLKRAEQQE S


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