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Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) (Myocardial collagenase) (Fragment)

 MMP1_RAT                Reviewed;          15 AA.
P81563;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 1.
12-SEP-2018, entry version 63.
RecName: Full=Interstitial collagenase;
EC=3.4.24.7;
AltName: Full=Fibroblast collagenase;
AltName: Full=Matrix metalloproteinase-1;
Short=MMP-1;
AltName: Full=Myocardial collagenase;
Flags: Fragment;
Name=Mmp1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
PROTEIN SEQUENCE.
TISSUE=Heart;
PubMed=8605638;
Tyagi S.C., Cleutjens J.P.M.;
"Myocardial collagenase: purification and structural
characterization.";
Can. J. Cardiol. 12:165-171(1996).
-!- FUNCTION: Cleaves collagens of types I, II, and III at one site in
the helical domain. Also cleaves collagens of types VII and X. May
play a role in the deterioration of the heart wall extracellular
matrix proteins during the onset of dilated cardiomyopathy.
-!- CATALYTIC ACTIVITY: Cleavage of the triple helix of collagen at
about three-quarters of the length of the molecule from the N-
terminus, at 775-Gly-|-Ile-776 in the alpha-1(I) chain. Cleaves
synthetic substrates and alpha-macroglobulins at bonds where P1'
is a hydrophobic residue.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
Note=Binds 4 Ca(2+) ions per subunit. {ECO:0000250};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
-!- ACTIVITY REGULATION: Can be activated without removal of the
activation peptide.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix {ECO:0000250}.
-!- PTM: The N-terminus is blocked.
-!- PTM: Tyrosine phosphorylated in platelets by PKDCC/VLK.
{ECO:0000250|UniProtKB:P03956}.
-!- SIMILARITY: Belongs to the peptidase M10A family. {ECO:0000305}.
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UniGene; Rn.79007; -.
BRENDA; 3.4.24.7; 5301.
Proteomes; UP000002494; Unplaced.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.
1: Evidence at protein level;
Calcium; Collagen degradation; Complete proteome;
Direct protein sequencing; Extracellular matrix; Hydrolase;
Metalloprotease; Phosphoprotein; Protease; Reference proteome;
Secreted; Zinc.
CHAIN <1 >15 Interstitial collagenase.
/FTId=PRO_0000078182.
NON_TER 1 1
NON_TER 15 15
SEQUENCE 15 AA; 1787 MW; 15A57D24C0F6FD80 CRC64;
DTLKSEKNAD FKDLY


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