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Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)

 PPBI_BOVIN              Reviewed;         533 AA.
P19111; Q28124;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
30-AUG-2017, entry version 126.
RecName: Full=Intestinal-type alkaline phosphatase;
Short=IAP;
Short=Intestinal alkaline phosphatase;
EC=3.1.3.1;
Flags: Precursor;
Name=ALPI;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
PubMed=8452539; DOI=10.1042/bj2900503;
Weissig H., Schildge A., Hoylaerts M.F., Iqbal M., Millan J.L.;
"Cloning and expression of the bovine intestinal alkaline phosphatase
gene: biochemical characterization of the recombinant enzyme.";
Biochem. J. 290:503-508(1993).
[2]
PROTEIN SEQUENCE OF 20-35 AND 91-152, AND ACTIVE SITE.
TISSUE=Intestine;
PubMed=3902089; DOI=10.1016/0167-4838(85)90115-3;
Culp J.S., Hermodson M., Butler L.G.;
"The active-site and amino-terminal amino acid sequence of bovine
intestinal alkaline phosphatase.";
Biochim. Biophys. Acta 831:330-334(1985).
[3]
PROTEIN SEQUENCE OF 20-63.
PubMed=3458202; DOI=10.1073/pnas.83.8.2368;
Hua J.-C., Berger J., Pan Y.C.E., Hulmes J.D., Udenfriend S.;
"Partial sequencing of human adult, human fetal, and bovine intestinal
alkaline phosphatases: comparison with the human placental and liver
isozymes.";
Proc. Natl. Acad. Sci. U.S.A. 83:2368-2372(1986).
-!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
phosphate. {ECO:0000255|PROSITE-ProRule:PRU10042}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 1 Mg(2+) ion. {ECO:0000250};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 2 Zn(2+) ions. {ECO:0000250};
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
-!- MISCELLANEOUS: In most mammals there are four different isozymes:
placental, placental-like, intestinal and tissue non-specific
(liver/bone/kidney).
-!- SIMILARITY: Belongs to the alkaline phosphatase family.
{ECO:0000305}.
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EMBL; L07733; AAA30571.1; -; Genomic_DNA.
PIR; S30364; S30364.
UniGene; Bt.106; -.
ProteinModelPortal; P19111; -.
SMR; P19111; -.
IntAct; P19111; 2.
STRING; 9913.ENSBTAP00000005937; -.
BindingDB; P19111; -.
ChEMBL; CHEMBL5695; -.
DrugBank; DB09413; Monopotassium phosphate.
PaxDb; P19111; -.
PRIDE; P19111; -.
eggNOG; KOG4126; Eukaryota.
eggNOG; COG1785; LUCA.
HOGENOM; HOG000099118; -.
HOVERGEN; HBG007345; -.
InParanoid; P19111; -.
BRENDA; 3.1.3.1; 908.
SABIO-RK; P19111; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0004035; F:alkaline phosphatase activity; ISS:UniProtKB.
GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0016311; P:dephosphorylation; ISS:UniProtKB.
CDD; cd16012; ALP; 1.
Gene3D; 3.40.720.10; -; 1.
InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
InterPro; IPR001952; Alkaline_phosphatase.
InterPro; IPR018299; Alkaline_phosphatase_AS.
InterPro; IPR017850; Alkaline_phosphatase_core.
PANTHER; PTHR11596; PTHR11596; 1.
Pfam; PF00245; Alk_phosphatase; 1.
PRINTS; PR00113; ALKPHPHTASE.
SMART; SM00098; alkPPc; 1.
SUPFAM; SSF53649; SSF53649; 1.
PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein;
Magnesium; Membrane; Metal-binding; Reference proteome; Signal;
Transmembrane; Zinc.
SIGNAL 1 19 {ECO:0000269|PubMed:3458202,
ECO:0000269|PubMed:3902089}.
CHAIN 20 506 Intestinal-type alkaline phosphatase.
/FTId=PRO_0000024035.
PROPEP 507 533 Removed in mature form. {ECO:0000250}.
/FTId=PRO_0000024036.
ACT_SITE 111 111 Phosphoserine intermediate.
{ECO:0000255|PROSITE-ProRule:PRU10042,
ECO:0000269|PubMed:3902089}.
METAL 61 61 Magnesium. {ECO:0000250}.
METAL 61 61 Zinc 1. {ECO:0000250}.
METAL 111 111 Zinc 1. {ECO:0000250}.
METAL 174 174 Magnesium. {ECO:0000250}.
METAL 330 330 Magnesium. {ECO:0000250}.
METAL 335 335 Zinc 2. {ECO:0000250}.
METAL 339 339 Zinc 2; via tele nitrogen. {ECO:0000250}.
METAL 376 376 Zinc 1. {ECO:0000250}.
METAL 377 377 Zinc 1; via tele nitrogen. {ECO:0000250}.
METAL 451 451 Zinc 2; via tele nitrogen. {ECO:0000250}.
LIPID 506 506 GPI-anchor amidated aspartate.
{ECO:0000250}.
CARBOHYD 268 268 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 429 429 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 140 202 {ECO:0000250}.
DISULFID 486 493 {ECO:0000250}.
CONFLICT 148 150 VTS -> TSV (in Ref. 2; AA sequence).
{ECO:0000305}.
SEQUENCE 533 AA; 57100 MW; D74456F3F1F06714 CRC64;
MQGACVLLLL GLHLQLSLGL VPVEEEDPAF WNRQAAQALD VAKKLQPIQT AAKNVILFLG
DGMGVPTVTA TRILKGQMNG KLGPETPLAM DQFPYVALSK TYNVDRQVPD SAGTATAYLC
GVKGNYRTIG VSAAARYNQC KTTRGNEVTS VMNRAKKAGK SVGVVTTTRV QHASPAGAYA
HTVNRNWYSD ADLPADAQMN GCQDIAAQLV NNMDIDVILG GGRKYMFPVG TPDPEYPDDA
SVNGVRKRKQ NLVQAWQAKH QGAQYVWNRT ALLQAADDSS VTHLMGLFEP ADMKYNVQQD
HTKDPTLQEM TEVALRVVSR NPRGFYLFVE GGRIDHGHHD DKAYMALTEA GMFDNAIAKA
NELTSELDTL ILVTADHSHV FSFGGYTLRG TSIFGLAPSK ALDSKSYTSI LYGNGPGYAL
GGGSRPDVND STSEDPSYQQ QAAVPQASET HGGEDVAVFA RGPQAHLVHG VEEETFVAHI
MAFAGCVEPY TDCNLPAPTT ATSIPDAAHL AASPPPLALL AGAMLLLLAP TLY


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