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Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1) (Alkaline phosphatase 3)

 PPBI_MOUSE              Reviewed;         559 AA.
P24822;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
22-NOV-2017, entry version 129.
RecName: Full=Intestinal-type alkaline phosphatase;
Short=IAP;
Short=Intestinal alkaline phosphatase;
EC=3.1.3.1;
AltName: Full=Alkaline phosphatase 3;
Flags: Precursor;
Name=Iap; Synonyms=Akp-3, Akp3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2286375; DOI=10.1016/0888-7543(90)90042-S;
Manes T., Glade K., Ziomek C.A., Millan J.L.;
"Genomic structure and comparison of mouse tissue-specific alkaline
phosphatase genes.";
Genomics 8:541-554(1990).
-!- CATALYTIC ACTIVITY: A phosphate monoester + H(2)O = an alcohol +
phosphate. {ECO:0000255|PROSITE-ProRule:PRU10042}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 1 Mg(2+) ion. {ECO:0000250};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 2 Zn(2+) ions. {ECO:0000250};
-!- SUBUNIT: Homodimer.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor,
GPI-anchor {ECO:0000305}.
-!- TISSUE SPECIFICITY: Intestine and thymus.
-!- MISCELLANEOUS: In most mammals there are four different isozymes:
placental, placental-like, intestinal and tissue non-specific
(liver/bone/kidney).
-!- SIMILARITY: Belongs to the alkaline phosphatase family.
{ECO:0000305}.
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EMBL; M61705; AAA37873.1; -; Genomic_DNA.
CCDS; CCDS15127.1; -.
PIR; B36307; B36307.
UniGene; Mm.377076; -.
ProteinModelPortal; P24822; -.
SMR; P24822; -.
STRING; 10090.ENSMUSP00000037497; -.
BindingDB; P24822; -.
ChEMBL; CHEMBL3151; -.
iPTMnet; P24822; -.
PhosphoSitePlus; P24822; -.
MaxQB; P24822; -.
PaxDb; P24822; -.
PeptideAtlas; P24822; -.
PRIDE; P24822; -.
MGI; MGI:87984; Akp3.
eggNOG; KOG4126; Eukaryota.
eggNOG; COG1785; LUCA.
HOGENOM; HOG000099118; -.
HOVERGEN; HBG007345; -.
InParanoid; P24822; -.
PhylomeDB; P24822; -.
PRO; PR:P24822; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
GO; GO:0005903; C:brush border; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0004035; F:alkaline phosphatase activity; ISS:UniProtKB.
GO; GO:0000287; F:magnesium ion binding; ISS:UniProtKB.
GO; GO:0002020; F:protease binding; ISO:MGI.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0016311; P:dephosphorylation; ISS:UniProtKB.
GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
GO; GO:0021915; P:neural tube development; IMP:MGI.
GO; GO:0022008; P:neurogenesis; IMP:MGI.
GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
CDD; cd16012; ALP; 1.
Gene3D; 3.40.720.10; -; 1.
InterPro; IPR017849; Alkaline_Pase-like_a/b/a.
InterPro; IPR001952; Alkaline_phosphatase.
InterPro; IPR018299; Alkaline_phosphatase_AS.
InterPro; IPR017850; Alkaline_phosphatase_core_sf.
PANTHER; PTHR11596; PTHR11596; 1.
Pfam; PF00245; Alk_phosphatase; 1.
PRINTS; PR00113; ALKPHPHTASE.
SMART; SM00098; alkPPc; 1.
SUPFAM; SSF53649; SSF53649; 1.
PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond; Glycoprotein;
GPI-anchor; Hydrolase; Lipoprotein; Magnesium; Membrane;
Metal-binding; Reference proteome; Signal; Zinc.
SIGNAL 1 19 {ECO:0000255}.
CHAIN 20 528 Intestinal-type alkaline phosphatase.
/FTId=PRO_0000024039.
PROPEP 529 559 Removed in mature form. {ECO:0000255}.
/FTId=PRO_0000024040.
COMPBIAS 503 507 Poly-Thr.
COMPBIAS 510 524 Poly-Thr.
ACT_SITE 111 111 Phosphoserine intermediate.
METAL 61 61 Magnesium. {ECO:0000250}.
METAL 61 61 Zinc 1. {ECO:0000250}.
METAL 111 111 Zinc 1. {ECO:0000250}.
METAL 174 174 Magnesium. {ECO:0000250}.
METAL 330 330 Magnesium. {ECO:0000250}.
METAL 335 335 Zinc 2. {ECO:0000250}.
METAL 339 339 Zinc 2; via tele nitrogen. {ECO:0000250}.
METAL 376 376 Zinc 1. {ECO:0000250}.
METAL 377 377 Zinc 1; via tele nitrogen. {ECO:0000250}.
METAL 450 450 Zinc 2; via tele nitrogen. {ECO:0000250}.
LIPID 528 528 GPI-anchor amidated asparagine.
{ECO:0000255}.
CARBOHYD 141 141 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 241 241 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 426 426 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 140 202 {ECO:0000250}.
DISULFID 485 492 {ECO:0000250}.
SEQUENCE 559 AA; 60285 MW; 019EBB4363950878 CRC64;
MQGPWVLLLL GLRLQLSLSV IPVEEENPAF WNKKAAEALD AAKKLQPIQT SAKNLIIFLG
DGMGVPTVTA TRILKGQLEG HLGPETPLAM DRFPYMALSK TYSVDRQVPD SASTATAYLC
GVKTNYKTIG LSAAARFDQC NTTFGNEVFS VMYRAKKAGK SVGVVTTTRV QHASPSGTYV
HTVNRNWYGD ADMPASALRE GCKDIATQLI SNMDINVILG GGRKYMFPAG TPDPEYPNDA
NETGTRLDGR NLVQEWLSKH QGSQYVWNRE QLIQKAQDPS VTYLMGLFEP VDTKFDIQRD
PLMDPSLKDM TETAVKVLSR NPKGFYLFVE GGRIDRGHHL GTAYLALTEA VMFDLAIERA
SQLTSERDTL TIVTADHSHV FSFGGYTLRG TSIFGLAPLN ALDGKPYTSI LYGNGPGYVG
TGERPNVTAA ESSGSSYRRQ AAVPVKSETH GGEDVAIFAR GPQAHLVHGV QEQNYIAHVM
ASAGCLEPYT DCGLAPPADE SQTTTTTRQT TITTTTTTTT TTTTPVHNSA RSLGPATAPL
ALALLAGMLM LLLGAPAES


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