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Intraflagellar transport protein 20 homolog (mIFT20)

 IFT20_MOUSE             Reviewed;         132 AA.
Q61025; Q5SYG9; Q99M35;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 131.
RecName: Full=Intraflagellar transport protein 20 homolog;
Short=mIFT20;
Name=Ift20;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J;
PubMed=11916979; DOI=10.1083/jcb.200107108;
Pazour G.J., Baker S.A., Deane J.A., Cole D.G., Dickert B.L.,
Rosenbaum J.L., Witman G.B., Besharse J.C.;
"The intraflagellar transport protein, IFT88, is essential for
vertebrate photoreceptor assembly and maintenance.";
J. Cell Biol. 157:103-113(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=CD-1; TISSUE=Uterus;
Das N., Dey S.K.;
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Egg, and Kidney;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=Czech II; TISSUE=Mammary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
TISSUE SPECIFICITY, SUBUNIT, AND REGION.
PubMed=12821668; DOI=10.1074/jbc.M300156200;
Baker S.A., Freeman K., Luby-Phelps K., Pazour G.J., Besharse J.C.;
"IFT20 links kinesin II with a mammalian intraflagellar transport
complex that is conserved in motile flagella and sensory cilia.";
J. Biol. Chem. 278:34211-34218(2003).
[7]
SUBCELLULAR LOCATION.
PubMed=15337773; DOI=10.1083/jcb.200405023;
Jurczyk A., Gromley A., Redick S., San Agustin J., Witman G.,
Pazour G.J., Peters D.J.M., Doxsey S.;
"Pericentrin forms a complex with intraflagellar transport proteins
and polycystin-2 and is required for primary cilia assembly.";
J. Cell Biol. 166:637-643(2004).
[8]
FUNCTION, SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=16775004; DOI=10.1091/mbc.E06-02-0133;
Follit J.A., Tuft R.A., Fogarty K.E., Pazour G.J.;
"The intraflagellar transport protein IFT20 is associated with the
Golgi complex and is required for cilia assembly.";
Mol. Biol. Cell 17:3781-3792(2006).
[9]
IDENTIFICATION IN THE IFT COMPLEX B, INTERACTION WITH IFT88, AND
SUBCELLULAR LOCATION.
PubMed=19253336; DOI=10.1002/cm.20346;
Follit J.A., Xu F., Keady B.T., Pazour G.J.;
"Characterization of mouse IFT complex B.";
Cell Motil. Cytoskeleton 66:457-468(2009).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Kidney, Liver, Lung, Pancreas, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[11]
FUNCTION.
PubMed=24089209; DOI=10.1038/nature12639;
Pampliega O., Orhon I., Patel B., Sridhar S., Diaz-Carretero A.,
Beau I., Codogno P., Satir B.H., Satir P., Cuervo A.M.;
"Functional interaction between autophagy and ciliogenesis.";
Nature 502:194-200(2013).
[12]
SUBCELLULAR LOCATION.
PubMed=25243405; DOI=10.1371/journal.pone.0108470;
Broekhuis J.R., Verhey K.J., Jansen G.;
"Regulation of cilium length and intraflagellar transport by the RCK-
kinases ICK and MOK in renal epithelial cells.";
PLoS ONE 9:E108470-E108470(2014).
-!- FUNCTION: Part of intraflagellar transport (IFT) particles
involved in ciliary process assembly. May play a role in the
trafficking of ciliary membrane proteins from the Golgi complex to
the cilium. Also involved in autophagy since it is required for
trafficking of ATG16L and the expansion of the autophagic
compartment. {ECO:0000269|PubMed:16775004,
ECO:0000269|PubMed:24089209}.
-!- SUBUNIT: Interacts with CEP83 (By similarity). Component of the
IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25,
IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81,
and IFT88. Interacts directly with IFT57 and KIF3B/Kinesin II
subunit. Interacts with IFT88. {ECO:0000250,
ECO:0000269|PubMed:12821668, ECO:0000269|PubMed:16775004,
ECO:0000269|PubMed:19253336}.
-!- INTERACTION:
Q8C0J2:Atg16l1; NbExp=2; IntAct=EBI-16077253, EBI-769195;
-!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
{ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:19253336}.
Cytoplasm, cytoskeleton, microtubule organizing center,
centrosome, centriole {ECO:0000269|PubMed:15337773}. Cytoplasm,
cytoskeleton, cilium basal body {ECO:0000269|PubMed:15337773,
ECO:0000269|PubMed:16775004}. Cell projection, cilium
{ECO:0000269|PubMed:25243405}. Note=Present at the centrosomes
during the cell cycle and associated with the proximal portion of
the mother centriole and the lateral aspect of the daughter
centriole. Associated with basal body at the base of primary
cilia.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q61025-1; Sequence=Displayed;
Name=2;
IsoId=Q61025-2; Sequence=VSP_020392;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in testis, kidney and retina.
{ECO:0000269|PubMed:11916979, ECO:0000269|PubMed:12821668}.
-!- MISCELLANEOUS: Cells that stably express short interference RNAs
targeting IFT20 show reduced centriolar IFT20 and lack primary
cilia.
-!- SEQUENCE CAUTION:
Sequence=CAI25553.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
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EMBL; AY082613; AAL99202.1; -; mRNA.
EMBL; U38981; AAA81518.1; -; mRNA.
EMBL; AK002397; BAB22069.1; -; mRNA.
EMBL; AK139942; BAE24189.1; -; mRNA.
EMBL; AL591177; CAI25553.1; ALT_SEQ; Genomic_DNA.
EMBL; AL591177; CAI25554.1; -; Genomic_DNA.
EMBL; BC002040; AAH02040.1; -; mRNA.
CCDS; CCDS25111.1; -. [Q61025-1]
RefSeq; NP_061342.1; NM_018854.4. [Q61025-1]
UniGene; Mm.358671; -.
BioGrid; 207750; 4.
DIP; DIP-60602N; -.
IntAct; Q61025; 1.
STRING; 10090.ENSMUSP00000103910; -.
PhosphoSitePlus; Q61025; -.
PaxDb; Q61025; -.
PeptideAtlas; Q61025; -.
PRIDE; Q61025; -.
Ensembl; ENSMUST00000108275; ENSMUSP00000103910; ENSMUSG00000001105. [Q61025-1]
Ensembl; ENSMUST00000128788; ENSMUSP00000118015; ENSMUSG00000001105. [Q61025-1]
GeneID; 55978; -.
KEGG; mmu:55978; -.
UCSC; uc007kjs.1; mouse. [Q61025-1]
CTD; 90410; -.
MGI; MGI:1915585; Ift20.
eggNOG; ENOG410IW7Z; Eukaryota.
eggNOG; ENOG4111NRP; LUCA.
GeneTree; ENSGT00390000003413; -.
HOGENOM; HOG000230527; -.
HOVERGEN; HBG081781; -.
InParanoid; Q61025; -.
KO; K16473; -.
OMA; IEADQNE; -.
OrthoDB; EOG091G0VSN; -.
PhylomeDB; Q61025; -.
TreeFam; TF319434; -.
Reactome; R-MMU-5620924; Intraflagellar transport.
PRO; PR:Q61025; -.
Proteomes; UP000000589; Chromosome 11.
Bgee; ENSMUSG00000001105; -.
ExpressionAtlas; Q61025; baseline and differential.
Genevisible; Q61025; MM.
GO; GO:0005814; C:centriole; IDA:MGI.
GO; GO:0005813; C:centrosome; IDA:MGI.
GO; GO:0036064; C:ciliary basal body; IDA:MGI.
GO; GO:0097546; C:ciliary base; IDA:MGI.
GO; GO:0005929; C:cilium; IDA:UniProtKB.
GO; GO:0005801; C:cis-Golgi network; ISO:MGI.
GO; GO:0044292; C:dendrite terminus; IDA:MGI.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
GO; GO:1902636; C:kinociliary basal body; IDA:MGI.
GO; GO:0005902; C:microvillus; IDA:MGI.
GO; GO:0031514; C:motile cilium; IDA:MGI.
GO; GO:0032391; C:photoreceptor connecting cilium; IDA:MGI.
GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
GO; GO:0032420; C:stereocilium; IDA:MGI.
GO; GO:0002046; F:opsin binding; IPI:MGI.
GO; GO:0017137; F:Rab GTPase binding; ISO:MGI.
GO; GO:0055007; P:cardiac muscle cell differentiation; IMP:MGI.
GO; GO:0051642; P:centrosome localization; IMP:MGI.
GO; GO:0060271; P:cilium assembly; IMP:MGI.
GO; GO:0090102; P:cochlea development; IMP:MGI.
GO; GO:0001736; P:establishment of planar polarity; IMP:MGI.
GO; GO:0060122; P:inner ear receptor stereocilium organization; IMP:MGI.
GO; GO:0042073; P:intraciliary transport; IMP:MGI.
GO; GO:0035735; P:intraciliary transport involved in cilium assembly; TAS:Reactome.
GO; GO:0001822; P:kidney development; IMP:MGI.
GO; GO:0061351; P:neural precursor cell proliferation; IMP:MGI.
GO; GO:0022008; P:neurogenesis; IMP:MGI.
GO; GO:0036372; P:opsin transport; IMP:MGI.
GO; GO:0035845; P:photoreceptor cell outer segment organization; IMP:MGI.
GO; GO:0061512; P:protein localization to cilium; IMP:MGI.
GO; GO:0034067; P:protein localization to Golgi apparatus; ISO:MGI.
GO; GO:0072659; P:protein localization to plasma membrane; IMP:MGI.
GO; GO:2000785; P:regulation of autophagosome assembly; IMP:UniProtKB.
GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IMP:MGI.
GO; GO:1902017; P:regulation of cilium assembly; IMP:UniProtKB.
GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
GO; GO:0008542; P:visual learning; IMP:MGI.
InterPro; IPR028172; FT20.
PANTHER; PTHR31978; PTHR31978; 1.
Pfam; PF14931; IFT20; 1.
1: Evidence at protein level;
Alternative splicing; Cell projection; Cilium;
Cilium biogenesis/degradation; Coiled coil; Complete proteome;
Cytoplasm; Cytoskeleton; Golgi apparatus; Reference proteome.
CHAIN 1 132 Intraflagellar transport protein 20
homolog.
/FTId=PRO_0000249304.
REGION 70 132 IFT57-binding.
COILED 74 116 {ECO:0000255}.
VAR_SEQ 107 132 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_020392.
SEQUENCE 132 AA; 15237 MW; A0E797D01CFD001D CRC64;
MAKDILGEAG LHFDELNKLR VLDPEVTQQT VELKEECKDF VDKIGQFQKI VGGLIELVDQ
LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK KTQLERYRVE YEALCKVEAE
QNEFIDQFIF QK


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