Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Intraflagellar transport protein 46 (Flagellar-associated protein 32) (IFT complex B protein)

 IFT46_CHLRE             Reviewed;         344 AA.
A2T2X4; A8JIV6;
05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
06-MAR-2007, sequence version 1.
22-NOV-2017, entry version 49.
RecName: Full=Intraflagellar transport protein 46;
AltName: Full=Flagellar-associated protein 32;
AltName: Full=IFT complex B protein {ECO:0000312|EMBL:ABH06907.1};
Name=IFT46 {ECO:0000312|EMBL:ABH06907.1}; Synonyms=FAP32;
ORFNames=CHLREDRAFT_108954;
Chlamydomonas reinhardtii (Chlamydomonas smithii).
Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae;
Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
NCBI_TaxID=3055;
[1] {ECO:0000305, ECO:0000312|EMBL:ABH06907.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
DISRUPTION PHENOTYPE.
PubMed=17312020; DOI=10.1083/jcb.200608041;
Hou Y., Qin H., Follit J.A., Pazour G.J., Rosenbaum J.L., Witman G.B.;
"Functional analysis of an individual IFT protein: IFT46 is required
for transport of outer dynein arms into flagella.";
J. Cell Biol. 176:653-665(2007).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CC-503, and cw92;
PubMed=17932292; DOI=10.1126/science.1143609;
Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K.,
Marechal-Drouard L., Marshall W.F., Qu L.H., Nelson D.R.,
Sanderfoot A.A., Spalding M.H., Kapitonov V.V., Ren Q., Ferris P.,
Lindquist E., Shapiro H., Lucas S.M., Grimwood J., Schmutz J.,
Cardol P., Cerutti H., Chanfreau G., Chen C.L., Cognat V., Croft M.T.,
Dent R., Dutcher S., Fernandez E., Fukuzawa H., Gonzalez-Ballester D.,
Gonzalez-Halphen D., Hallmann A., Hanikenne M., Hippler M., Inwood W.,
Jabbari K., Kalanon M., Kuras R., Lefebvre P.A., Lemaire S.D.,
Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L., Mittag M.,
Mittelmeier T., Moroney J.V., Moseley J., Napoli C., Nedelcu A.M.,
Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J., Purton S.,
Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L., Schroda M.,
Stern D., Umen J., Willows R., Wilson N., Zimmer S.L., Allmer J.,
Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P.,
Jorgensen R., Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T.,
Brokstein P., Dubchak I., Goodstein D., Hornick L., Huang Y.W.,
Jhaveri J., Luo Y., Martinez D., Ngau W.C., Otillar B., Poliakov A.,
Porter A., Szajkowski L., Werner G., Zhou K., Grigoriev I.V.,
Rokhsar D.S., Grossman A.R.;
"The Chlamydomonas genome reveals the evolution of key animal and
plant functions.";
Science 318:245-250(2007).
[3] {ECO:0000305}
SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=15955805; DOI=10.1074/jbc.M505062200;
Lucker B.F., Behal R.H., Qin H., Siron L.C., Taggart W.D.,
Rosenbaum J.L., Cole D.G.;
"Characterization of the intraflagellar transport complex B core:
direct interaction of the IFT81 and IFT74/72 subunits.";
J. Biol. Chem. 280:27688-27696(2005).
[4]
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=15998802; DOI=10.1083/jcb.200504008;
Pazour G.J., Agrin N., Leszyk J., Witman G.B.;
"Proteomic analysis of a eukaryotic cilium.";
J. Cell Biol. 170:103-113(2005).
[5] {ECO:0000305}
INTERACTION WITH DAW1, AND SUBCELLULAR LOCATION.
PubMed=18852297; DOI=10.1083/jcb.200802025;
Ahmed N.T., Gao C., Lucker B.F., Cole D.G., Mitchell D.R.;
"ODA16 aids axonemal outer row dynein assembly through an interaction
with the intraflagellar transport machinery.";
J. Cell Biol. 183:313-322(2008).
[6] {ECO:0000305}
INTERACTION WITH IFT25, AND SUBCELLULAR LOCATION.
PubMed=19382199; DOI=10.1002/cm.20369;
Lechtreck K.F., Luro S., Awata J., Witman G.B.;
"HA-tagging of putative flagellar proteins in Chlamydomonas
reinhardtii identifies a novel protein of intraflagellar transport
complex B.";
Cell Motil. Cytoskeleton 66:469-482(2009).
[7] {ECO:0000305}
SUBCELLULAR LOCATION.
PubMed=19412537; DOI=10.1371/journal.pone.0005384;
Wang Z., Fan Z.C., Williamson S.M., Qin H.;
"Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein
component of IFT complex B and physically interacts with IFT27 in
Chlamydomonas.";
PLoS ONE 4:E5384-E5384(2009).
[8] {ECO:0000305}
FUNCTION, INTERACTION WITH IFT52 AND IFT88, AND DISRUPTION PHENOTYPE.
PubMed=20435895; DOI=10.1074/jbc.M110.106997;
Lucker B.F., Miller M.S., Dziedzic S.A., Blackmarr P.T., Cole D.G.;
"Direct interactions of intraflagellar transport complex B proteins
IFT88, IFT52, and IFT46.";
J. Biol. Chem. 285:21508-21518(2010).
[9] {ECO:0000305}
INTERACTION WITH IFT70.
PubMed=20534810; DOI=10.1091/mbc.E10-03-0191;
Fan Z.C., Behal R.H., Geimer S., Wang Z., Williamson S.M., Zhang H.,
Cole D.G., Qin H.;
"Chlamydomonas IFT70/CrDYF-1 is a core component of IFT particle
complex B and is required for flagellar assembly.";
Mol. Biol. Cell 21:2696-2706(2010).
-!- FUNCTION: Forms part of a complex involved in intraflagellar
transport (IFT), the bi-directional movement of particles required
for the assembly, maintenance and functioning of primary cilia.
Plays a role in maintaining IFT complex B stability.
{ECO:0000269|PubMed:17312020, ECO:0000269|PubMed:20435895}.
-!- SUBUNIT: Component of the IFT complex B, the core composed of
IFT25, IFT27, IFT46, IFT52, IFT74, IFT81 and IFT88 as well as
associated subunits IFT20, IFT57, IFT80 and IFT172. Interacts with
IFT25, IFT52, IFT70, IFT88 AND DAW1. {ECO:0000269|PubMed:15955805,
ECO:0000269|PubMed:18852297, ECO:0000269|PubMed:19382199,
ECO:0000269|PubMed:20435895, ECO:0000269|PubMed:20534810}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
{ECO:0000269|PubMed:15955805, ECO:0000269|PubMed:17312020,
ECO:0000269|PubMed:18852297, ECO:0000269|PubMed:19382199,
ECO:0000269|PubMed:19412537}. Cell projection, cilium
{ECO:0000269|PubMed:15955805, ECO:0000269|PubMed:17312020,
ECO:0000269|PubMed:18852297, ECO:0000269|PubMed:19382199,
ECO:0000269|PubMed:19412537}. Note=Expression is concentrated at
the cilium basal body but is also detected along the length of the
cilium. {ECO:0000269|PubMed:15955805, ECO:0000269|PubMed:17312020,
ECO:0000269|PubMed:18852297, ECO:0000269|PubMed:19382199,
ECO:0000269|PubMed:19412537}.
-!- DISRUPTION PHENOTYPE: Individuals have short, non-motile
flagellae. {ECO:0000269|PubMed:17312020,
ECO:0000269|PubMed:20435895}.
-!- SIMILARITY: Belongs to the IFT46 family. {ECO:0000255}.
-!- SEQUENCE CAUTION:
Sequence=EDO96191.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; DQ787426; ABH06907.1; -; mRNA.
EMBL; DS496218; EDO96191.1; ALT_SEQ; Genomic_DNA.
RefSeq; XP_001691140.1; XM_001691088.1.
UniGene; Cre.8330; -.
SMR; A2T2X4; -.
STRING; 3055.EDO96191; -.
PaxDb; A2T2X4; -.
EnsemblPlants; EDO96191; EDO96191; CHLREDRAFT_108954.
GeneID; 5716734; -.
Gramene; EDO96191; EDO96191; CHLREDRAFT_108954.
KEGG; cre:CHLREDRAFT_108954; -.
eggNOG; ENOG410IHUT; Eukaryota.
eggNOG; ENOG410ZYJI; LUCA.
InParanoid; A2T2X4; -.
KO; K19682; -.
OMA; WPPEVET; -.
Proteomes; UP000006906; Unassembled WGS sequence.
GO; GO:0097546; C:ciliary base; IDA:MGI.
GO; GO:0060170; C:ciliary membrane; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
GO; GO:0031514; C:motile cilium; IDA:BHF-UCL.
GO; GO:0008022; F:protein C-terminus binding; IPI:BHF-UCL.
GO; GO:0035082; P:axoneme assembly; IMP:MGI.
GO; GO:0060271; P:cilium assembly; IMP:BHF-UCL.
GO; GO:0044782; P:cilium organization; IMP:MGI.
GO; GO:0060285; P:cilium-dependent cell motility; IMP:MGI.
GO; GO:0042073; P:intraciliary transport; IDA:BHF-UCL.
GO; GO:0050821; P:protein stabilization; IDA:BHF-UCL.
GO; GO:0015031; P:protein transport; IMP:MGI.
GO; GO:1902017; P:regulation of cilium assembly; IMP:MGI.
GO; GO:0031647; P:regulation of protein stability; IMP:MGI.
InterPro; IPR022088; Intraflagellar_transp_cmplxB.
PANTHER; PTHR13376; PTHR13376; 1.
Pfam; PF12317; IFT46_B_C; 1.
1: Evidence at protein level;
Cell projection; Cilium; Complete proteome; Cytoplasm; Cytoskeleton;
Reference proteome.
CHAIN 1 344 Intraflagellar transport protein 46.
/FTId=PRO_0000399500.
COMPBIAS 329 333 Poly-Gly. {ECO:0000255}.
SEQUENCE 344 AA; 37935 MW; 33D1C0837A17D62E CRC64;
MDDSMDYPDR DGDDLDQFQG TARSQVVQNQ PHDEEVNLSE SESFAGADEP PAAPRDASLI
ESHDMDEGPA APARTLSPTG YEAGKHAPGG IANSDEAPPG AYNAQEYKHL NVGEDVRELF
SYIGRYKPQT VELDTRIKPF IPDYIPAVGG IDEFIKVPRP DTKPDYLGLK VLDEPAAKQS
DPTVLTLQLR QLSKEAPGAK ADMVGRLEHT DENKAKKIQQ WIASINDIHK AKPAATVNYS
KRMPEIEALM QEWPPEVETF LKTMHMPSGD VELDIKTYAR LVCTLLDIPV YDDPVESLHV
LFTLYLEFKN NPIFRQHMEM ENKLDGMSGG GGGMMGGGAD VLGL


Related products :

Catalog number Product name Quantity
EIAAB46169 Homo sapiens,Human,IFT121,Intraflagellar transport protein 121 homolog,KIAA1336,WD repeat-containing protein 35,WDR35
CNB-1440051 Human Intraflagellar Transport Protein 27 ELISA Ki 96T
E2806h Human Intraflagellar Transport Protein 74 ELISA Ki 96T
E6239h Human Intraflagellar Transport Protein 52 ELISA Ki 96T
E5270h Human Intraflagellar Transport Protein 122 ELISA K 96T
E3831h Human Intraflagellar Transport Protein 80 ELISA Ki 96T
E14725h Human Intraflagellar Transport Protein 81 ELISA Ki 96T
E2807h Human Intraflagellar Transport Protein 20 ELISA Ki 96T
E7233h Human Intraflagellar Transport Protein 46 ELISA Ki 96T
E2805h Human Intraflagellar Transport Protein 88 ELISA Ki 96T
E14469h Human Intraflagellar Transport Protein 57 ELISA Ki 96T
E0088p Mouse ELISA Kit FOR Intraflagellar transport protein 20 homolog 96T
E15001c Human ELISA Kit FOR Intraflagellar transport protein 81 homolog 96T
CSB-EL011078RA Rat Intraflagellar transport protein 80 homolog(IFT80) ELISA kit 96T
IFT74_HUMAN Human ELISA Kit FOR Intraflagellar transport protein 74 homolog 96T
E10128m Mouse ELISA Kit FOR Intraflagellar transport protein 81 homolog 96T
IFT80_MOUSE Mouse ELISA Kit FOR Intraflagellar transport protein 80 homolog 96T
TMM8B_HUMAN Human ELISA Kit FOR Intraflagellar transport protein 20 homolog 96T
E0676r Bovine ELISA Kit FOR Intraflagellar transport protein 57 homolog 96T
E0626m Human ELISA Kit FOR Intraflagellar transport protein 20 homolog 96T
E1493r Bovine ELISA Kit FOR Intraflagellar transport protein 27 homolog 96T
S12A7_RAT Mouse ELISA Kit FOR Intraflagellar transport protein 20 homolog 96T
CSB-EL011079RA Rat Intraflagellar transport protein 81 homolog(IFT81) ELISA kit 96T
RHBD3_RAT Bovine ELISA Kit FOR Intraflagellar transport protein 57 homolog 96T
CSB-EL011073RA Rat Intraflagellar transport protein 172 homolog(IFT172) ELISA kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur