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Intraflagellar transport protein 56 (Protein hop-sterile) (Tetratricopeptide repeat protein 26) (TPR repeat protein 26)

 IFT56_MOUSE             Reviewed;         554 AA.
Q8BS45;
29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
07-JUN-2017, entry version 119.
RecName: Full=Intraflagellar transport protein 56 {ECO:0000303|PubMed:24596149};
AltName: Full=Protein hop-sterile {ECO:0000303|PubMed:25340710};
AltName: Full=Tetratricopeptide repeat protein 26 {ECO:0000312|MGI:MGI:2444853};
Short=TPR repeat protein 26 {ECO:0000312|MGI:MGI:2444853};
Name=Ttc26 {ECO:0000312|MGI:MGI:2444853};
Synonyms=Hop {ECO:0000303|PubMed:25340710},
Ift56 {ECO:0000303|PubMed:24596149};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Pancreas, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[4]
TISSUE SPECIFICITY, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=22718903; DOI=10.1091/mbc.E12-01-0019;
Zhang Q., Liu Q., Austin C., Drummond I., Pierce E.A.;
"Knockdown of ttc26 disrupts ciliogenesis of the photoreceptor cells
and the pronephros in zebrafish.";
Mol. Biol. Cell 23:3069-3078(2012).
[5]
SUBCELLULAR LOCATION, AND IDENTIFICATION IN THE IFT COMPLEX B.
PubMed=24596149; DOI=10.7554/eLife.01566;
Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
Marshall W.F.;
"TTC26/DYF13 is an intraflagellar transport protein required for
transport of motility-related proteins into flagella.";
Elife 3:E01566-E01566(2014).
[6]
ERRATUM.
PubMed=24692455; DOI=10.7554/eLife.02897;
Ishikawa H., Ide T., Yagi T., Jiang X., Hirono M., Sasaki H.,
Yanagisawa H., Wemmer K.A., Stainier D.Y., Qin H., Kamiya R.,
Marshall W.F.;
Elife 3:E02897-E02897(2014).
[7]
FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, IDENTIFICATION IN
THE IFT COMPLEX B, AND INTERACTION WITH IFT46.
PubMed=25340710; DOI=10.1371/journal.pgen.1004689;
Swiderski R.E., Nakano Y., Mullins R.F., Seo S., Banfi B.;
"A mutation in the mouse ttc26 gene leads to impaired hedgehog
signaling.";
PLoS Genet. 10:E1004689-E1004689(2014).
-!- FUNCTION: Component of the intraflagellar transport (IFT) complex
B required for transport of proteins in the motile cilium.
Required for transport of specific ciliary cargo proteins related
to motility, while it is neither required for IFT complex B
assembly or motion nor for cilium assembly. Required for efficient
coupling between the accumulation of GLI3 at the ciliary tip and
its dissociation from SUFU. {ECO:0000269|PubMed:22718903,
ECO:0000269|PubMed:25340710}.
-!- SUBUNIT: Component of the IFT complex B. Interacts with IFT46; the
interaction is direct. {ECO:0000269|PubMed:24596149}.
-!- SUBCELLULAR LOCATION: Cell projection, cilium
{ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:24596149}.
Note=Localizes at the base to the ciliary transition zone.
{ECO:0000269|PubMed:22718903, ECO:0000269|PubMed:24596149}.
-!- TISSUE SPECIFICITY: High expression detected in testis. Detected
also retina, kidney, lung and brain tissue. The expression level
is low in liver and spleen (PubMed:22718903). Present in the
airway epithelial cells and the testes (at protein level)
(PubMed:25340710). {ECO:0000269|PubMed:22718903,
ECO:0000269|PubMed:25340710}.
-!- DISRUPTION PHENOTYPE: Partial embryonic lethality and patterning
defects. Surviving mice show hopping gait, polydactyly,
hydrocephalus, and male sterility. Impaired hedgehog signaling.
Primary cilia are not reduced in number and their length is
normal. {ECO:0000269|PubMed:25340710}.
-!- SIMILARITY: Belongs to the IFT56 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AK035185; BAC28974.1; -; mRNA.
EMBL; BC066060; AAH66060.1; -; mRNA.
CCDS; CCDS51750.1; -.
RefSeq; NP_705828.2; NM_153600.2.
UniGene; Mm.253446; -.
ProteinModelPortal; Q8BS45; -.
STRING; 10090.ENSMUSP00000124369; -.
iPTMnet; Q8BS45; -.
PhosphoSitePlus; Q8BS45; -.
MaxQB; Q8BS45; -.
PaxDb; Q8BS45; -.
PRIDE; Q8BS45; -.
DNASU; 264134; -.
Ensembl; ENSMUST00000162554; ENSMUSP00000124369; ENSMUSG00000056832.
GeneID; 264134; -.
KEGG; mmu:264134; -.
UCSC; uc009bkc.1; mouse.
CTD; 79989; -.
MGI; MGI:2444853; Ttc26.
eggNOG; KOG3785; Eukaryota.
eggNOG; ENOG410XRMP; LUCA.
GeneTree; ENSGT00390000000159; -.
HOGENOM; HOG000258854; -.
HOVERGEN; HBG108610; -.
InParanoid; Q8BS45; -.
KO; K19685; -.
OMA; KKLMSFH; -.
OrthoDB; EOG091G04RS; -.
PhylomeDB; Q8BS45; -.
TreeFam; TF105816; -.
Reactome; R-MMU-5620924; Intraflagellar transport.
PRO; PR:Q8BS45; -.
Proteomes; UP000000589; Chromosome 6.
Bgee; ENSMUSG00000056832; -.
CleanEx; MM_TTC26; -.
ExpressionAtlas; Q8BS45; baseline and differential.
Genevisible; Q8BS45; MM.
GO; GO:0005813; C:centrosome; IDA:MGI.
GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
GO; GO:0005929; C:cilium; IDA:UniProtKB.
GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
GO; GO:0042073; P:intraciliary transport; IMP:UniProtKB.
GO; GO:0046530; P:photoreceptor cell differentiation; ISO:MGI.
GO; GO:0008594; P:photoreceptor cell morphogenesis; ISO:MGI.
GO; GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
GO; GO:0007286; P:spermatid development; IMP:MGI.
Gene3D; 1.25.40.10; -; 3.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR011990; TPR-like_helical_dom.
InterPro; IPR030511; TTC26.
PANTHER; PTHR14781:SF1; PTHR14781:SF1; 1.
SUPFAM; SSF48452; SSF48452; 4.
PROSITE; PS50293; TPR_REGION; 2.
1: Evidence at protein level;
Cell projection; Cilium; Complete proteome; Protein transport;
Reference proteome; Repeat; TPR repeat; Transport.
CHAIN 1 554 Intraflagellar transport protein 56.
/FTId=PRO_0000289084.
REPEAT 57 90 TPR 1.
REPEAT 92 125 TPR 2.
REPEAT 151 184 TPR 3.
REPEAT 468 501 TPR 4.
SEQUENCE 554 AA; 64151 MW; C126B8B129EA1306 CRC64;
MMLSRAKPAV GGESPHTDKR KKKGRKIPKL EDLLSQRDFT GAITLLEFKR HVGEQEDDTN
LWIGYCAFHL GDYKRALEEY ENATKEENCN PEVWVNLACT YFFLGMYKQA EAAGFKAPKS
RLQNRLLFHL AHKFNDEKKL MNFHQNLQDI KEDQLSLASI HYMRSHYQEA IDIYKRILLD
NREYLALNVY VALCYYKLDY YDVSQEVLAV YLQQIPDSTI ALNLKACNHF RLYNGKAAEA
ELKSLMDNAS SPFEFAKELI RHNLVVFRGG EGALQVLPPL VDVIPEARLN LVIYYLRQDD
VQEAYNLIKD LEPTTPQEYI LKGVVNAALG QEMGSRDHMK IAQQFFQLVG GSASECDTIP
GRQCMASCFF LLKQFDDVLI YLNSFKSYFY NDDIFNFNYA QAKAATGNTS EGEEVFLLIQ
SEKLKNDYIY LSWLARCYIM NKKPRLAWEL YLKMETSGES FSLLQLIAND CYKMGQFYYS
AKAFDVLERL DPNPEYWEGK RGACVGIFQM ILAGREPKET LREVLHLLRS TGNTQVEYII
RIMKKWAKEN RVPI


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