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Intron-associated endonuclease 1 (EC 3.1.-.-) (I-TevI) (IRF protein)

 TEV1_BPT4               Reviewed;         245 AA.
P13299; Q9T0T3;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
15-JUL-1999, sequence version 2.
25-OCT-2017, entry version 108.
RecName: Full=Intron-associated endonuclease 1;
EC=3.1.-.-;
AltName: Full=I-TevI;
AltName: Full=IRF protein;
Name=ITEVIR;
Enterobacteria phage T4 (Bacteriophage T4).
Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae;
Tevenvirinae; T4virus.
NCBI_TaxID=10665;
NCBI_TaxID=562; Escherichia coli.
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ALC4;
PubMed=3698096; DOI=10.1016/0092-8674(86)90379-X;
Chu F.K., Maley G.F., West D.K., Belfort M., Maley F.;
"Characterization of the intron in the phage T4 thymidylate synthase
gene and evidence for its self-excision from the primary transcript.";
Cell 45:157-166(1986).
[2]
SEQUENCE REVISION TO 67.
Chu F.K.;
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12626685; DOI=10.1128/MMBR.67.1.86-156.2003;
Miller E.S., Kutter E., Mosig G., Arisaka F., Kunisawa T., Ruger W.;
"Bacteriophage T4 genome.";
Microbiol. Mol. Biol. Rev. 67:86-156(2003).
[4]
IDENTIFICATION OF PROTEIN.
PubMed=2543665;
West D.K., Changchien L.-M., Maley G.F., Maley F.;
"Evidence that the intron open reading frame of the phage T4 td gene
encodes a specific endonuclease.";
J. Biol. Chem. 264:10343-10346(1989).
-!- FUNCTION: This endonuclease is specific to the thymidylate
synthase (td) gene splice junction and is involved in intron
homing.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- SIMILARITY: To endonucleases of group I introns of fungi and
phage. {ECO:0000305}.
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EMBL; M12742; AAC12817.1; -; Genomic_DNA.
EMBL; AF158101; AAD42521.3; -; Genomic_DNA.
PIR; T10130; T10130.
RefSeq; NP_049849.3; NC_000866.4.
PDB; 1I3J; X-ray; 2.20 A; A=130-245.
PDB; 1LN0; X-ray; 2.00 A; A/B=1-97.
PDB; 1MK0; X-ray; 1.60 A; A=1-97.
PDB; 1T2T; X-ray; 2.50 A; A=130-245.
PDBsum; 1I3J; -.
PDBsum; 1LN0; -.
PDBsum; 1MK0; -.
PDBsum; 1T2T; -.
ProteinModelPortal; P13299; -.
SMR; P13299; -.
DrugBank; DB04272; Citric Acid.
MoonProt; P13299; -.
REBASE; 2625; I-TevI.
PRIDE; P13299; -.
GeneID; 1258722; -.
KEGG; vg:1258722; -.
OrthoDB; VOG090000LF; -.
EvolutionaryTrace; P13299; -.
Proteomes; UP000009087; Genome.
GO; GO:0017053; C:transcriptional repressor complex; IMP:CAFA.
GO; GO:0001218; F:bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding; IMP:CAFA.
GO; GO:0003677; F:DNA binding; IDA:CAFA.
GO; GO:0004519; F:endonuclease activity; IDA:CAFA.
GO; GO:0043565; F:sequence-specific DNA binding; IMP:CAFA.
GO; GO:0008270; F:zinc ion binding; IMP:CAFA.
GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:CAFA.
GO; GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IDA:CAFA.
Gene3D; 3.40.1440.10; -; 1.
InterPro; IPR000305; GIY-YIG_endonuc.
InterPro; IPR035901; GIY-YIG_endonuc_sf.
InterPro; IPR006350; Intron_endoG1.
InterPro; IPR003611; NUMOD3.
Pfam; PF01541; GIY-YIG; 1.
Pfam; PF07460; NUMOD3; 2.
SMART; SM00465; GIYc; 1.
SMART; SM00496; IENR2; 2.
SUPFAM; SSF82771; SSF82771; 1.
TIGRFAMs; TIGR01453; grpIintron_endo; 1.
PROSITE; PS50164; GIY_YIG; 1.
1: Evidence at protein level;
3D-structure; Complete proteome; Endonuclease; Hydrolase;
Intron homing; Magnesium; Nuclease; Reference proteome.
CHAIN 1 245 Intron-associated endonuclease 1.
/FTId=PRO_0000192792.
DOMAIN 1 88 GIY-YIG. {ECO:0000255|PROSITE-
ProRule:PRU00977}.
STRAND 4 10 {ECO:0000244|PDB:1MK0}.
TURN 11 13 {ECO:0000244|PDB:1MK0}.
STRAND 16 23 {ECO:0000244|PDB:1MK0}.
HELIX 24 37 {ECO:0000244|PDB:1MK0}.
HELIX 43 52 {ECO:0000244|PDB:1MK0}.
STRAND 56 63 {ECO:0000244|PDB:1MK0}.
HELIX 68 81 {ECO:0000244|PDB:1MK0}.
TURN 82 86 {ECO:0000244|PDB:1MK0}.
STRAND 87 89 {ECO:0000244|PDB:1MK0}.
STRAND 154 156 {ECO:0000244|PDB:1T2T}.
TURN 165 167 {ECO:0000244|PDB:1I3J}.
HELIX 172 174 {ECO:0000244|PDB:1I3J}.
TURN 176 179 {ECO:0000244|PDB:1I3J}.
HELIX 184 194 {ECO:0000244|PDB:1I3J}.
STRAND 205 207 {ECO:0000244|PDB:1I3J}.
STRAND 210 214 {ECO:0000244|PDB:1I3J}.
HELIX 215 222 {ECO:0000244|PDB:1I3J}.
HELIX 226 234 {ECO:0000244|PDB:1I3J}.
STRAND 240 242 {ECO:0000244|PDB:1I3J}.
SEQUENCE 245 AA; 28232 MW; 29DF2ACF08ECD64C CRC64;
MKSGIYQIKN TLNNKVYVGS AKDFEKRWKR HFKDLEKGCH SSIKLQRSFN KHGNVFECSI
LEEIPYEKDL IIERENFWIK ELNSKINGYN IADATFGDTC STHPLKEEII KKRSETVKAK
MLKLGPDGRK ALYSKPGSKN GRWNPETHKF CKCGVRIQTS AYTCSKCRNR SGENNSFFNH
KHSDITKSKI SEKMKGKKPS NIKKISCDGV IFDCAADAAR HFKISSGLVT YRVKSDKWNW
FYINA


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