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Intron-encoded DNA endonuclease aI5 alpha (DNA endonuclease I-SceIV) [Cleaved into: Truncated non-functional cytochrome oxidase 1; DNA endonuclease aI5 alpha (EC 3.1.-.-) (Intron-encoded endonuclease I-SceIV)]

 SCE4_YEAST              Reviewed;         630 AA.
Q9ZZX1; A0A0A7NYD1; Q8W770;
09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
05-DEC-2018, entry version 131.
RecName: Full=Intron-encoded DNA endonuclease aI5 alpha;
AltName: Full=DNA endonuclease I-SceIV;
Contains:
RecName: Full=Truncated non-functional cytochrome oxidase 1;
Contains:
RecName: Full=DNA endonuclease aI5 alpha;
EC=3.1.-.-;
AltName: Full=Intron-encoded endonuclease I-SceIV;
Flags: Precursor;
Name=AI5_ALPHA; Synonyms=I-SCEIV {ECO:0000303|PubMed:9675098};
OrderedLocusNames=Q0070;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Mitochondrion.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=9872396; DOI=10.1016/S0014-5793(98)01467-7;
Foury F., Roganti T., Lecrenier N., Purnelle B.;
"The complete sequence of the mitochondrial genome of Saccharomyces
cerevisiae.";
FEBS Lett. 440:325-331(1998).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 96604 / S288c / FY1679;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
FUNCTION, CLEAVAGE SITE SPECIFICITY, ENDONUCLEASE ACTIVITY, AND INTRON
HOMING.
PubMed=1314207; DOI=10.1016/0378-1119(92)90663-A;
Seraphin B., Faye G., Hatat D., Jacq C.;
"The yeast mitochondrial intron aI5 alpha: associated endonuclease
activity and in vivo mobility.";
Gene 113:1-8(1992).
[4]
FUNCTION, COFACTOR, CLEAVAGE SITE SPECIFICITY, ENDONUCLEASE ACTIVITY,
PH OPTIMUM, AND SUBUNIT.
PubMed=9675098; DOI=10.1006/bbrc.1998.8921;
Wernette C.M.;
"Structure and activity of the mitochondrial intron-encoded
endonuclease, I-SceIV.";
Biochem. Biophys. Res. Commun. 248:127-133(1998).
-!- FUNCTION: Mitochondrial DNA endonuclease involved in intron
homing. It introduces a specific double-strand break in the DNA of
the COX1 gene and thus mediates the insertion of an intron,
containing its own coding sequence (group I intron), into an
intronless gene. Recognizes with limited specificity and cleaves
the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the
nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH.
{ECO:0000250|UniProtKB:P03878, ECO:0000269|PubMed:1314207,
ECO:0000269|PubMed:9675098}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000269|PubMed:9675098};
-!- BIOPHYSICOCHEMICAL PROPERTIES:
pH dependence:
Optimum pH is 9.5. {ECO:0000269|PubMed:9675098};
-!- SUBUNIT: Heterodimer of a 32 kDa catalytic subunit and a larger 60
kDa polypeptide subunit. {ECO:0000269|PubMed:9675098}.
-!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}. Membrane
{ECO:0000255, ECO:0000305}; Multi-pass membrane protein
{ECO:0000255, ECO:0000305}.
-!- PTM: The mature protein may arise from proteolytic cleavage of an
in-frame translation of some COX1 exons plus the intron containing
the aI5_alpha open reading frame. {ECO:0000269|PubMed:1314207,
ECO:0000269|PubMed:9675098}.
-!- SIMILARITY: In the N-terminal section; belongs to the heme-copper
respiratory oxidase family. {ECO:0000255}.
-!- SIMILARITY: In the C-terminal section; belongs to the LAGLIDADG
endonuclease family. {ECO:0000255}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; KP263414; AIZ98882.1; -; Genomic_DNA.
PIR; S78650; S78650.
RefSeq; NP_009306.1; NC_001224.1.
ProteinModelPortal; Q9ZZX1; -.
SMR; Q9ZZX1; -.
BioGrid; 34789; 2.
STRING; 4932.Q0070; -.
PaxDb; Q9ZZX1; -.
PRIDE; Q9ZZX1; -.
EnsemblFungi; Q0070_mRNA; Q0070_mRNA; Q0070.
GeneID; 854597; -.
KEGG; sce:Q0070; -.
SGD; S000007265; AI5_ALPHA.
GeneTree; ENSGT00390000001518; -.
InParanoid; Q9ZZX1; -.
OrthoDB; EOG092C2KU4; -.
BioCyc; YEAST:G3O-34376-MONOMER; -.
PRO; PR:Q9ZZX1; -.
Proteomes; UP000002311; Mitochondrion.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IBA:GO_Central.
GO; GO:0005739; C:mitochondrion; TAS:SGD.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
GO; GO:0004519; F:endonuclease activity; IMP:SGD.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
GO; GO:0015990; P:electron transport coupled proton transport; IBA:GO_Central.
GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IBA:GO_Central.
GO; GO:0006316; P:movement of group I intron; IMP:SGD.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
Gene3D; 1.20.210.10; -; 1.
Gene3D; 3.10.28.10; -; 1.
InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
InterPro; IPR000883; Cyt_C_Oxase_1.
InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
InterPro; IPR027434; Homing_endonucl.
InterPro; IPR004860; LAGLIDADG_2.
PANTHER; PTHR10422; PTHR10422; 1.
Pfam; PF00115; COX1; 1.
Pfam; PF03161; LAGLIDADG_2; 1.
PRINTS; PR01165; CYCOXIDASEI.
SUPFAM; SSF55608; SSF55608; 1.
SUPFAM; SSF81442; SSF81442; 1.
PROSITE; PS50855; COX1; 1.
PROSITE; PS00077; COX1_CUB; 1.
1: Evidence at protein level;
Complete proteome; Endonuclease; Hydrolase; Intron homing; Membrane;
Mitochondrion; mRNA processing; mRNA splicing; Nuclease;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 ? Truncated non-functional cytochrome
oxidase 1.
/FTId=PRO_0000270983.
CHAIN ? 630 DNA endonuclease aI5 alpha.
/FTId=PRO_0000270984.
TRANSMEM 16 36 Helical. {ECO:0000255}.
TRANSMEM 57 77 Helical. {ECO:0000255}.
TRANSMEM 101 121 Helical. {ECO:0000255}.
TRANSMEM 147 167 Helical. {ECO:0000255}.
TRANSMEM 182 202 Helical. {ECO:0000255}.
TRANSMEM 235 255 Helical. {ECO:0000255}.
TRANSMEM 267 287 Helical. {ECO:0000255}.
TRANSMEM 305 325 Helical. {ECO:0000255}.
TRANSMEM 417 437 Helical. {ECO:0000255}.
TRANSMEM 464 483 Helical. {ECO:0000255}.
REGION 1 324 COX1 exons encoded. {ECO:0000255}.
REGION 325 630 COX1 intron aI5_alpha encoded.
COMPBIAS 333 390 Asn-rich. {ECO:0000255}.
SEQUENCE 630 AA; 72165 MW; 6EA9AA02CD2A6C16 CRC64;
MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG NSQLFNVLVV
GHAVLMIFFL VMPALIGGFG NYLLPLMIGA TDTAFPRINN IAFWVLPMGL VCLVTSTLVE
SGAGTGWTVY PPLSSIQAHS GPSVDLAIFA LHLTSISSLL GAINFIVTTL NMRTNGMTMH
KLPLFVWSIF ITAFLLLLSL PVLSAGITML LLDRNFNTSF FEVSGGGDPI LYEHLFWFFG
HPEVYILIIP GFGIISHVVS TYSKKPVFGE ISMVYAMASI GLLGFLVWSH HMYIVGLDAD
TRAYFTSATM IIAIPTGIKI FSWLMNPFSK DKNKNKNKKL IRNYQKMNNN NMMKTYLNNN
NMIMMNMYKG NLYDIYPRSN RNYIQPNNIN KELVVYGYNL ESCVGMPTYT NIVKHMVGIP
NNILYIMTGI LLTDGWIDYT SKKDLDKKTI MEINCRFRLK QSMIHSEYLM YVFMLLSHYC
MSYPKMKIAK VKGKSYNQLE FYTRSLPCFT ILRYMFYNGR VKIVPNNLYD LLNYESLAHM
IMCDGSFVKG GGLYLNLQSF TTKELIFIMN ILKIKFNLNC TLHKSRNKYT IYMRVESVKR
LFPMIYKYIL PSMRYKFDIM LWQKKYNMIN


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